[Effects of artificial ventilation of the upper respiratory passages with ozone on cardiac and respiratory functions in the rabbit].
Explore the source record for details and available documents.
Animals↗
Biomedical subjects
M Zicot
Publications and source records attributed to M Zicot.
Pathological aspects of carotid plaques. Surgical and clinical significance.
We examined 134 carotid plaques microscopically in 125 consecutive patients, and found 21 (15.7%) had simple fibrous plaques versus 113 (84.3%) complicated plaques. The following plaque characteristics were present: intraplaque hemorrhage (73 plaques), ulceration (83 plaques), fresh thrombus (93 plaques), and recanalized thrombus (22 plaques). An average of 2.4 characteristics were observed in each complicated plaque. The only significant (p less than 0.05) clinico-pathologic correlation was the presence of fresh thrombi, found in 80% of the plaques from patients with a previous transient ischemic attack, in 93% of those with nonfocal neurologic symptoms, and in 80% of those with amaurosis fugax. Analysing the localization of the fresh thrombus (mural or intraluminal), we found that fresh thrombus in symptomatic plaques was most frequently (NS) (71 to 77%) exposed to the vessel lumen. Ulceration without fresh thrombus, plaque hemorrhage and recanalized thrombus were also found in a considerable number of asymptomatic patients, of whom 85% (33/41) presented a form of complicated plaque.
Adult↗
The assessment of chronic venous obstructions by non invasive haemodynamic studies and imaging with Kr-81 m venography.
We study the sequelae of venous obstructions (from 15 days to several years after the thrombosis) by non invasive haemodynamic methods: Doppler velocimetry and leg plethysmography. We describe a simple physical model which permits the calculation of the leg outflow resistance from the venous occlusion plethysmography data. A radionuclide imaging of the veins is also recorded by a gammacamera during the perfusion of the limbs with Kr-81 m. This flexible technique appears suitable to analyse persistent ilio-femoro-popliteal obstructions. The results of the Doppler investigation are well related to the phlebograms. The outflow resistance of the leg depends mainly on the duration of the persistent obstruction. Recent obstructions are generally highly resistive but the level of the resistance is becoming close to normal with time (after two years).
Chronic Disease↗
[Medical treatment of the Raynaud phenomenon].
The medical treatment of Raynaud's phenomenon must be adapted to each particular case. Benign cases do not require drug therapy. Various substances seem able to relieve the most severe cases (calcium blockers, alpha-blockers). Prostaglandins perfusions and plasmaphoresis must be reserved for the most severe cases, with trophic disorders not improved with less aggressive treatments.
Angiotensin-Converting Enzyme Inhibitors↗
[Clinical approach to the patient with polyvascular disease].
The history and the physical examination are important steps in the clinical approach to the polyvascular patient. They are the foundation of a rational diagnostic and therapeutic management. Complementary investigations are nevertheless necessary. Ultrasonography has become an essential complement to the physical examination. Its field covers all peripheral vessels: supra-aortic arteries, aorta and its branches, limb arteries. The ultrasound are applied following continuous and pulsed Doppler and real time echography. The two methods may be combined (duplex echography). The investigations are performed first at rest, but assessments under strain are often necessary. The cardiac examination has been enriched by modern methods: thallium scintigraphy under dipyridamole is specially useful in order to measure the coronary reserve. Angiographic images are still a must for most of the aggressive therapeutic decisions. The modern techniques are more flexible using digitalization and a suitable investigation is chosen in function of each individual condition.
Angiography↗
[Is transcutaneous oxygen diffusion measurement a prognostic criterion for artificial limb adaptation and rehabilitation of lower limb amputees?].
Explore the source record for details and available documents.
Aged↗
Effect of exercise on the leg distribution of C15O2 and 15O2 in normals and in patients with peripheral ischemia: a study using positron tomography.
In order to evaluate regional muscle blood flow and oxygen utilization, we study with positron emission tomography (PET) the distribution of C15O2 and 15O2 in 17 subjects: 5 normals (24 +/- 3 years) and 12 patients (63 +/- 13.5 years). C15O2 and 15O2 are inhalated with a steady-state technique. Positron tomograms are recorded in supine position at the greatest diameter of the leg. Exercise consists in simultaneous ankle flexions. In all normals, C15O2 and 15O2 are distributed homogeneously and symmetrically in both legs. At rest, they concentrate in the region of vascular pedicle. After exercise, C15O2 and 15O2 are electively distributed in the anterolateral region of the leg. In patients, this pattern of distribution is similar but asymmetrical. Moreover, the regional uptake of C15O2 and 15O2 often dissociates. In conclusion, C15O2 and 15O2 allow to study repeatedly muscle blood flow and oxygen utilization in patients with peripheral ischemia, both at rest and after exercise. The broad spectrum of pathological changes observed in this study needs further metabolic investigations.
Adult↗