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Biomedical subjects

M Zenz

Publications and source records attributed to M Zenz.

158 records · Page 9Linked to original sources
PubMed1981

[Epidural morphine analgesia. Postoperative period (author's transl)].

50 patients after abdominal surgery received peridural morphine for postoperative pain relief. At the end of operation, 2-3 mg morphine in 10-15 ml 0,9% saline were injected peridurally by a catheter, which was placed preoperatively. The injection was followed by a dissociated analgesia. Diffuse pain and wound pain were diminished. Pin prick and temperature were still perceived. Analgesia started within 2-5 min after injection and lasted 14 h in the mean (range 1-49 h). The degree of analgesia was determined by a visual analogue scoring system. The patients reported a marked pain relief. A new dose of 2 mg morphine was given on demand, when the patients felt pain again. This procedure was continued until the second postoperative day. The overall amount of morphine by peridural application was 8 mg within 3 days. Neither clinically nor by blood gas analyzes here were signs of respiratory depression. There were no severe side effects. The advantages of epidural morphine analgesia are: low dose, long duration, lack of sedation and motor block, lack of respiratory depression, tachyphylaxia and sympathetic block. No pneumonia were seen in the epidural morphine group, whereas 4 cases of pneumonia were seen in the control group (n = 50) with conventional analgetics.

Abdomen↗
PubMed1981

[Epidural morphine analgesia (PMA). III. Cancer pain (author's transl)].

The effect of PMA in pain therapy was investigated over a period of one year on 52 patients suffering from terminal cancer. These patients, 22 being outpatients, received a total number of 85 peridural catheters. 75 of these catheters were evaluated according to morphine dosage and effect. The onset of PMA resulted in a drastic reduction in the need for high dose systemically applied analgesics. PMA was also successfully applied in cases with rapidly spreading metastases. Our catheters have remained in place up to 170 days. Side effects were rarely observed. Tachyphylaxis did not develop and almost all patients were satisfied with the therapy. Due to special care of the catheter we observed only 7 cases of infected puncture sites. Our clinical studies have proven that peridural morphine analgesia can be successfully applied as pain therapy in patients suffering from terminal cancer.

Adolescent↗
PubMed1981

[Plethysmographic study on sympathetic block in peridural anaesthesia and peridural morphine analgesia (author's transl)].

Plethysmographic measurements were performed in 10 patients after peridural anaesthesia and peridural morphine analgesia. The arterial blood flow was increased after peridural anaesthesia. No increased venous pooling followed. After peridural morphine analgesia there are no changes of arterial blood flow and venous capacity. The peridural morphine analgesia represents no haemodynamic risk, because there is no sympathetic block

Adult↗
PubMed1981

[Epidural morphine analgesia (author's transl)].

We report our experience with epidural morphine analgesia. Morphine 2-3 mg in 10-15 ml 0.9% saline was given to patients after abdominal surgery, patients with terminal carcinoma and patients with multiple fractured ribs. Mean duration of analgesia was 14 hours and was not accompanied by severe complications.

Aged↗
PubMed1980

[Epidural morphine injections for the treatment of pain].

Morphine in epidural application (2-3 mg in 10 cc saline solution 0,9%) gives a long lasting segmental analgesia. In 15 patients after upperabdominal surgery the overall mean dosage of morphine was 8,85 mg within three days. The effect lasted for about 15 hours per application. No other analgetics were needed. All patients were content with this method of postoperative analgesia. There were no side effects or complications.

Adult↗
PubMed1980

[Pheochromocytoma in pregnancy--pathophysiology and therapy (author's transl)].

In this paper pathophysiology of pheochromocytoma and its modern diagnostic and therapeutic management are discussed with special regard to the combination of pheochromocytoma and pregnancy. The preoperative treatment with phenoxybenzamine is evaluated. As for the anesthetic management barbiturates and neurolept anesthesia are recommended. In the acute treatment of extreme blood pressure values sodium nitroprusside is preferred to phentolamine. Whereas vaginal delivery is contraindicated in a patient with pheochromocytoma there is no definite superiority of tumorresection along with caesarean section against a separate abdominal procedure.

Adrenal Gland Neoplasms↗
PubMed1979

[Investigation on the postoperative behavior of plasma amino acids in metabolically healthy patients. 1st communication (author's transl)].

In 12 patients before and after vaginal hysterectomy the plasma amino acid levels were determined. Without parenteral feeding the changes in plasma amino acid patterns can be explained by effects of operation and anaesthesia alone. The branched-chain amino acids decreased after operation. The following rise was never exceeding the control level. Even without substitution the concentrations of phenylalanine, methionine, and glutamic acid were increased. Tyrosine concentration remained within normal levels while cystine fell significantly.

Adult↗
PubMed1979

[Plasma amino acids and nitrogen balance during the postoperative period in metabolically healthy patients. 2nd communication (author's transl)].

Under parenteral and following oral nutrition in ten metabolically healthy patients the plasma amino acids were determined before and after vaginal hysterectomy. Starting from normal preoperative values there is a fall in the plasma concentration of most amino acids. The branched-chain amino acids decreased significantly, but under oral feeding they rose above the initial values. With increased plasma phenylalanine and methionine levels the concentration of cystine and tyrosine remained nearly unchanged. Glycine showed no increased levels while serine concentration was decreased even under substitution.

Adult↗
PubMed1975

A comparative study between etidocaine and bupivacaine in ulnar nerve block.

The long-acting local anaesthetics bupivacaine and etidocaine were compared in a double-blind study using ulnar nerve block. Eleven volunteers took part in the study. Solutions used were: bupivacaine 0.25% and 0.5% and etidocaine 0.5% and 1 %. All solutions contained adrenaline 5 mug/ml. The time of onset and duration of analgesia and motor block, degree of motor block, and changes in skin temperature were investigated. The results did not show any differences in the duration of sensory of motor block. Differences were seen in the degree of motor block in favour of etidocaine. The sympathetic block seemed to be more intense and of longer duration with bupivacaine. Etidocaine had a shorter time of onset in all nerve fibres.

Acetanilides↗