We outline the methods of Bayesian inference for applications to case-control studies. These methods appear as the natural way of making inferences, since much of the controversy that surrounds a specific case-control study is subjective. We derive conjugate prior distributions of exposure, posterior distributions of the ratio of the odds of being incident with a disease both with and without exposure to a potential causal agent, and convenient approximations. In particular, we show how one may carry out 'case-control studies' without necessarily having a control group. We illustrate these ideas with the data that first showed the relationship between in utero exposure to diethylstilbestrol and cancer of the vagina in young girls.

Adenocarcinoma↗

PubMedDate not supplied

Preliminary report on the treatment of nonresectable cancer of the lung.

Explore the source record for details and available documents.

Adenocarcinoma↗

PubMedDate not supplied

Pilot studies and new agent programs of the Eastern Cooperative Oncology Group.

The Eastern Cooperative Oncology Group (ECOG) has established two mechanisms for the study of new agents, including group A and B drugs and innovations in radiation therapy, namely, "pilot studies" and "master protocols." The master protocols allow for rapid accumulation of cases of tumor types of low incidence and the speedy completion of a study of new agents in common tumors. A new agents and pilot studies committee has been organized with responsibility for educational sessions, the introduction of new agents into either pilot studies or master protocols, and the review and monitoring of these programs. During its two years of operation, > 51 new studies have been initiated.

Antineoplastic Agents↗