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Biomedical subjects

M Zajac

Publications and source records attributed to M Zajac.

At least 55 records · Page 3Linked to original sources
PubMed1972

Lack of instrumental conditioning with intragastric reinforcement in normal experimental procedure.

The subject of this study was to check whether it would be possible to establish the alimentary instrumental reflex with direct intragastric reinforcement in normal experimental procedure. The experiment was carried out on ten male albino rats. Seven animals which were permanently implanted with intragastric tube constituted the experimental group. The remaining three rats served as controls. On the basis of obtained results we conclude the following: (i) in normal experimental procedure of conditioning it is impossible to establish a conditioned instrumental response with intragastric reinforcements, at least when the reinforcement amount is 0.5 ml; (ii) instrumental responses with intragastric reinforcement can be obtained using the method of transfer from reflexes with oral reinforcement.

Animals↗
PubMedDate not supplied

Redox methods validation of paracetamol and ascorbic acid in pharmaceutical preparations.

The contents of active substances were determined in a preparation TP-4 (tablets) containing paracetamol, ascorbic acid, caffeine and phenylephrine hydrochloride. For the determination of paracetamol and ascorbic acid a non-specific (cerometric and titration of 2,6-dichloroindophenol) method based on a redox reaction was used. Validation of the methods, performed on model mixtures, proved those methods to be accurate, precise, reproducible and linear within the range from 50% to 150% of the amount declared in the preparation. The content of paracetamol and ascorbic acid in TP-4, Thompayrin, Panadol Extra, Ring N, Polopiryna C, Efferalgan Vitamin C and Vitaminum C 0.2 satisfies the FP V demands (+/- 10% of the declared amount).

2,6-Dichloroindophenol↗
PubMedDate not supplied

UV/VIS spectrophotometric methods for determination of caffeine and phenylephrine hydrochloride in complex pharmaceutical preparations. Validation of the methods.

The contents of active substances were determined in a preparation TP-4 (tablets) containing paracetamol, ascorbic acid, caffeine and phenylephrine hydrochloride. For determination of caffeine and phenylephrine hydrochloride, UV/VIS spectrophotometric method was used. The VIS spectrophotometric method based on the reaction of phenylephrine with ninhydrine in sulphuric acid (1.127 kg/l). Validation of methods performed for model mixtures proved those methods were accurate, precise, repeatable and linear in the range from 50% to 150% of the amount declared in the preparation. The content of caffeine and phenylephrine hydrochloride in TP-4, Thompyrin, Panadol Extra, Ring N satisfies the FP V demands.

Caffeine↗
PubMedDate not supplied

Determination of cetirizine dichloride in tablets by HPLC method.

A HPLC method for the determination of the cetirizine dichloride in tablets was developed and validated. The determination was performed with a LiChrosorb RP-18 column, mobile phase of KH2PO4 (0.01 mol/l)--acetonitrile 65:35 (v/v), flow rate: 2 ml.min-1, UV detection at 230 nm and methyl paraben as an internal standard.

Anti-Allergic Agents↗