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Biomedical subjects

M Ye

Publications and source records attributed to M Ye.

At least 127 records · Page 7Linked to original sources
PubMed1991

Negative supercoiling increases the sensitivity of plasmid DNA to single-strand break induction by X-rays.

Negatively supercoiled topoisomers of the plasmid pIBI 30 were irradiated with 250 kV X-rays and assayed for strand scission by agarose gel electrophoresis. The survival of supercoiled molecules (Form I) decreased exponentially with increasing X-ray exposure and the dose required to reduce the fraction of DNA in Form I to 37% of its value in unirradiated controls (D37) decreased with increasing negative superhelicity. This enhanced radiation sensitivity of underwound DNA is tentatively attributed to the transient denaturation of the double helix that increases the susceptibility of individual strands to free radical attack.

DNA Damage↗
PubMed1991

[Observation on the behavior of microfilariae in human filariasis].

A total of 19 female adult filariae containing microfilariae in uteri collected from 25 filariasis patients were examined. Light transmission microscopic observations showed: (1) some of the adult worms entered the lumen of blood vessels by penetrating the venous wall and discharged immature and mature microfilariae and embryos into the blood stream; (2) microfilariae developed into maturation in the uterus of adult female worms, but when the adult worm began to degenerate, the microfilariae did not degenerate concurrently; (3) some microfilariae could form thrombus, inducing the infiltration of segmented neutrophils and eosinophils followed by the formation of granuloma; (4) embryos 8 female adults parasitizing lymphatics were seen to discharge immature microfilariae and ova, which might form emboli after entering the blood stream.

Adolescent↗
PubMed1990

[Biosynthests of glutathione in yeasts].

From 3091 strains of yeast, a strain of Candida sp K11 was selected which can produce 18 mg glutathione (GSH) by one gram of the dried cells in the presence of L-CySH in the culture medium. The original strain K11 was subjected to mutagenesis by ultraviolet irradiation and a strain of analogue-antimetabolic mutant K11 UE 126 was selected on the plate of GSH metabolic analogue ethionine. The content of GSH in the K11 UE 126 cells increased by 49.7% over the original strain K11 even without adding L-CySH in the culture medium.

Candida↗
PubMed1990

Virological survey of rhesus monkeys in China.

A virological survey of rhesus monkeys captured in China for 13 viruses and/or antibodies was performed. Antigens used were SFV, SF40, HSV-1, Sa11, measles, vaccinia, epidemic or simian hemorrhagic fever, Langat, Kunming, poliomyelitis, HIV, SV41 and rubella. Monkeys were from Sichuan, Hunan, Guizhou, Yunnan and Guangxi provinces. Antibody was detected to all the listed viruses except HIV, SV41 and rubella. Both SFV and SV40 were recovered from monkeys, but H. simiae, LCM and coxsackieviruses were not.

Animals↗
PubMed1989

Immunological studies on thromboangiitis obliterans.

Using humoral immunity (gamma-globulin 18 cases, IgG, IgA, IgM each 30 cases, CH50, C3, C4 each 29 cases and CIC 31 cases), cellular immunity (E-RFC 68 cases, As 30 cases, SmIg, SmIgG each 18 cases, IMIT 30 cases) and immunopathological manifestations (light microscope, fluorescence microscope, transmitted electron microscope each 7 cases) as indices, we studied the immunological changes of "progressing", "remittent" and "stabilized" groups of patients with thromboangiitis obliterans (TAO) in different stages. Humoral immunity indicated that gamma-globulin, immune complex and IgG were all increased; cellular immunity indicated that the rate of T cells and suppressor cells was declined, while that of B cells was elevated. Immunopathologically, under light microscope all the layers of involved vessels were infiltrated with neutrophils, lymphocytes and monocytes; under fluorescence and electron microscope, immune complexes were found in the involved vessel walls. Our preliminary results suggest that TAO is an autoimmune disease relevant to antigen-antibody complex.

Adult↗
PubMed1988

Salvage surgery for nasopharyngeal carcinoma.

Nasopharyngeal carcinoma is not a disease to be treated primarily by surgery. Radiation is the first choice of treatment. But, once it recurs, a second course of radiation controls only a small portion of the patients, with a high risk of accumulated radiation injury. We discuss the outcome of salvage surgery in nine cases of nasopharyngeal recurrence and 69 cases of neck metastasis that was uncontrolled or had recurred after irradiation was evaluated. A five-year survival rate of 44% for the primary lesions and 49% for the neck node metastases justifies the rationale of surgery on selected cases of radiation failure.

Adolescent↗
PubMed1988

[Proposal on T staging of maxillary sinus cancer].

The TNM staging of maxillary sinus cancer was stipulated by the UICC in 1987 using Ohngren line of demarcation. This report is to discuss the applicability of this staging based on 232 cases of maxillary sinus cancer treated in this hospital. Of 232 cases, the 3-year survival rate for those who received surgery alone was 4/6, for those after radical irradiation, 15.6% (20/128) and for those by combined irradiation and surgery, 43.9% (43/98). The 3-year survival rate for the whole series was 28.9%. To analyze the survival rates of different types of lesion separately, we found that those with involvement of the posterior wall, hence invading the pterygopalatine fossa had poor prognosis with a three year survival rate of 19.5%. And invasion of soft and/or hard palate also gave poor survival. Contrary to the common consensus, invasion of ethmoidal sinuses did not pose a serious prognosis. The feasibility of the Ohngren line in TNM staging was thus questioned. On the basis of our data, a modification of the TNM staging of JJC for maxillary sinus cancer is suggested.

Adult↗