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Biomedical subjects

M Yashiki

Publications and source records attributed to M Yashiki.

At least 73 records · Page 4Linked to original sources
PubMed1984

A fatal methamphetamine poisoning associated with hyperpyrexia.

After self-administration of 0.05 g of methamphetamine hydrochloride intravenously on three occasions at intervals of 3 h, a 25-year-old female methamphetamine abuser ingested approximately 1.5 g of methamphetamine hydrochloride, and was found dead 3-4 h later. Complete rigor mortis was observed 1-2 h after death and the rectal temperature was 38.4 degrees C 3-4 h after death. Distribution of methamphetamine and amphetamine in the body was analyzed by chemical ionization mass fragmentography. Amphetamine/methamphetamine concentrations (mumol/100 g) were 0.26/28.8 in blood, 0.64/68.2 in brain, 0.96/117.1 in liver, 0.53/50.6 in kidney, and 1.49/1045 in stomach contents. Total amount of methamphetamine hydrochloride in stomach contents was 11.6 mg. Amphetamine in tissues was a metabolite of methamphetamine, and amphetamine in stomach contents resulted from excretion into saliva and gastric mucous excretion. With rectal temperature at death estimated at more than 41 degrees C, it would seem that hyperpyrexia played an important role in causing death from methamphetamine poisoning.

Adult↗
PubMed1984

Articles found in the possession of a methamphetamine abuser.

A plastic syringe containing bloody fluid, 2 ampules of 20% glucose, and ampule containing diphenhydramine hydrochloride and calcium bromide, powder in a plastic bag and powder wrapped in paper were among the articles found in the possession of a 42-year-old male methamphetamine abuser, who had been taken to a mental hospital owing to his hallucinations. Examination of the patient revealed several recent needle punctures on the left forearm. The concentration of methamphetamine and its metabolite, amphetamine, in blood collected 1 day following the last intake was 76 nmol/100 g. Analysis of the powder and of the contents of the syringe revealed methamphetamine hydrochloride at a concentration of 99.0-99.5% and 7.4%, respectively. Neither glucose nor diphenhydramine were detected in the contents of the syringe. It would seem that the patient abused methamphetamine hydrochloride by intravenous injection after dissolving it in city water or distilled water.

Adult↗
PubMedDate not supplied

Postmortem formation of carbon monoxide.

Since carbon monoxide (CO) production after death was suggested in a drowned body, CO and carboxyhemoglobin (HbCO) levels in blood and body cavity fluids of cadavers which were not exposed to fire and CO hve been analyzed. CO released from the tissues was determined by gas chromatography and gas chromatography-mass spectrometry, and the total concentration of hemoglobin (Hb) was measured as cyanmethemoglobin (CNmHb). The HbCO level was calculated by the ratio of CO content and CO-binding capacity. CO levels (ml/100 g at STP) of the seven cases in which blood and body cavity fluids could be collected ranged from 0.13 to 0.87 in blood and 0.02 to 0.80 in body cavity fluids. HbCO levels in blood and body cavity fluids were from 0.3 to 6.0% and from 2.3 to 44.1%, respectively. In a typical case showing postmortem formation of CO, the CO levels in body cavity fluids were higher than that in blood. It is suggested that CO in a putrefied body is due to CO in blood prior to death and the CO formed by the decomposition of Hb, myoglobin and other substances during putrefaction. The significance of HbCO levels in body cavity fluids of cases with marked postmortem decomposition seems difficult to interpret without the value of HbCO in blood.

Adolescent↗
PubMedDate not supplied

Experimental study on postmortem formation of carbon monoxide.

Rats were drowned and kept immersed for 1 month in either boiled city water, or boiled or unboiled fresh water collected from a river. A small amount of carbon monoxide (CO) formed after death and a low carboxyhemoglobin (HbCO) saturation was found in blood and thoracic cavity fluid of the animals immersed in boiled city water and in boiled fresh water. A considerable amount of CO and a high HbCO saturation was observed in blood and thoracic cavity fluid in two out of three rats immersed in unboiled fresh water at 4-6 degrees C, and in one out of three at 6-16 degrees C. It is suggested that microorganisms in the water, in which the rats were drowned and kept immersed, and low temperatures of around 5 degrees C during storage, played an important role in the postmortem formation of carbon monoxide.

Animals↗