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Biomedical subjects

M Yamato

Publications and source records attributed to M Yamato.

At least 127 records · Page 7Linked to original sources
PubMed1984

Synthesis and antitumor activity of tropolone derivatives.

Treatment of tropolones with benzaldehyde diethyl acetals gave monotropolone (12) and bistropolone (13) derivatives at the benzylic position, whereas the related 1-ethoxyisochroman and the diethyl acetals of crotonaldehyde and cinnamaldehyde gave only the monotropolone derivatives (5, 10, or 11). The monotropolone derivatives (5, 10, 11, and 12) had poor potency against P388 leukemia in mice, but the bistropolone derivatives (13 and 14) showed significant potency and prolongation of life.

Animals↗
PubMed1981

Synthesis and structure-activity relationship of spiro[isochromanpiperidine] analogues for inhibition of histamine release.

Two types of 1'-alkylspiro[isochroman-3,4-piperidines] and 1'-alkylspiro[isochroman-4,4'-piperidines] were prepared and examined for their biological activity. Several of the compounds inhibited the compound 48/80 induced histamine release from isolated rat peritoneal mast cells. The structural requirements for this activity in the present series are discussed.

Animals↗