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Biomedical subjects

M Y Li

Publications and source records attributed to M Y Li.

61 records · Page 4Linked to original sources
PubMed1983

A modulatory lipoprotein related to cancer cell inhibition.

Three fractions of lipoprotein were isolated from sera and ascites of cancer-bearing mice by polyanion precipitation and density centrifugation. The cancer modulatory activity of isolated lipoproteins was estimated by means of trypan blue exclusion and cell potassium content. The activity of one of the isolated lipoprotein fractions was to kill cancer cells in vitro with little effect on normal bone marrow cells. This lipoprotein migrated as one band on agarose electrophoresis. After incubating cancer cells with the lipoprotein, the membrane fluidity of the cancer cells was markedly changed (p less than 0.01). The mechanism of modulation may be related to interaction of lipoprotein with plasma membrane of cancer cells.

Animals↗
PubMed1982

Purification and characterization of cancer suppressive factor.

Cancer suppressive factor (CSF) has been purified thousandfold from the ascites of mice. The purified factor possesses an activity to kill the cancer cells in vitro but little affects the bone marrow cells. Only one protein band has been observed on the polyacrylamide gel electrophoretogram of CSF. Its molecular weight is about 4,000 daltons as estimated by ultrafiltration method.

Animals↗
PubMedDate not supplied

Antagonistic action of orphanin FQ on acupuncture analgesia in rat brain.

The influence of orphanin FQ (OFQ) (a newly discovered 17-amino acid peptide) on acupuncture analgesia (AA) was assessed in rat tail-flick model. Intracerebroventricular (i.c.v.) injection of OFQ (1 microgram) elicited a significant decrement of pain threshold which was abolished by the repeated pretreatment with antisense oligonucleotide (ASO) to OFQ receptor. Electroacupuncture (EA) induced an obvious analgesic effect; when OFQ was used combined with EA, it showed a dose-dependent effect on antagonizing the EA analgesia. When rat was repeatedly i.c.v. injected with ASO to block the synthesis of OFQ receptor, the EA analgesia was enhanced markedly. In this instance, the OFQ did not show antagonistic effect on EA analgesia any more. The results suggest that the OFQ play its antagonistic role on EA analgesia via activating OFQ receptor.

Acupuncture Therapy↗