Reaction to trifluoperazine abuse.
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Adolescent↗
Biomedical subjects
M X FitzGerald
Publications and source records attributed to M X FitzGerald.
High resolution computed tomography in cystic fibrosis: correlation with pulmonary function and assessment of prognostic value.
OBJECTIVE: To assess the correlation between HRCT and pulmonary function in patients with CF. Further, to assess the prognostic value of HRCT in these patients. SUBJECTS AND METHODS: Clinical examination, chest radiographs and HRCT scans on 30 CF patients with an average age of 17 were scored using established scoring systems. The results were correlated with FEV1 and FVC both at time of CT scanning and after 30 months. Results were also correlated with the clinical progress of the patients over the follow-up period. RESULTS: HRCT, chest radiograph and clinical examination demonstrated similar correlation (p < 0.001) with FEV1 and FVC at the time of scanning. HRCT demonstrated the closest correlation with the clinical progress of the patients over the follow-up period and with follow-up pulmonary function. A maximum combined score for bronchiectasis and emphysema on HRCT seemed to indicate a poor prognosis. CONCLUSION: HRCT in CF patients correlates well with pulmonary function at time of scanning and at follow-up, and with clinical progress. There may be a role for CT in the identification of adolescent/adult patients who can be expected to need aggressive therapy in the future.
Adolescent↗
Reactive airways dysfunction syndrome (RADS) due to chlorine gas exposure.
Reactive Airways Dysfunction Syndrome (RADS) has been described following exposure to various irritant gases. We describe a case of RADS occurring following exposure to chlorine gas and which has persisted at 6 years follow-up.
Adolescent↗
Diabetes mellitus in an adult cystic fibrosis population.
Medical records of 132 patients attending an adult cystic fibrosis (CF) clinic were analysed to define the prevalence and clinical significance of diabetes mellitus (DM) in CF. Eighty four (63.6%) had normal blood glucose levels, 30 (22.8%) had hyperglycaemia only during intercurrent illness and 18 (13.6%) had DM. No significant differences were noted between the diabetic and non-diabetic groups for age, gender, height, weight, body mass index (BMI), forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) and pancreatic supplementation. Patients with hyperglycaemia during intercurrent illness had significantly lower BMI, FEV1% and FVC% than those with normal blood glucose levels. Of the diabetics four were managed on diet, three received oral hypoglycaemic agents and eleven were insulin requiring. The prevalence of DM in CF is considerable, severity of CF does not correlate with development of overt DM, and CF patients should be screened for DM by an oral glucose tolerance test on reaching adulthood.
Adult↗