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Biomedical subjects

M Worthington

Publications and source records attributed to M Worthington.

At least 55 records · Page 3Linked to original sources
PubMed1980

Mechanism of recovery from systemic herpes simplex virus infection. I. Comparative effectiveness of antibody and reconstitution of immune spleen cells on immunosuppressed mice.

The role of cellular immunity, humoral antibody, and interferon in recovery from primary systemic infection in mice due to herpes simplex virus type 1 (HSV-1) was studied. Immunosuppression by three methods--each of which was sufficient to suppress humoral and cellular immunity--markedly potentiated primary systemic HSV-1 infection. Immunosuppressed mice did not form neutralizing antibody to HSV-1, but passive transfer of physiologic amounts of neutralizing antibody as late as day 6 after infection exerted a protective effect. Passive transfer of 10(8) immune spleen cells on day 3 after infection was only partially protective and did not thereafter reverse the effect of X-irradiation on HSV-1 infection. Furthermore, mice that received immune cells appeared to make sufficient antibody to explain the protective effect of the transferred cells. These results suggest that antibody to HSV-1 has a critical role in promoting recovery from primary infection in this model. The findings neither favor nor exclude a defensive role for immune cells in this experimental primary HSV-1 infection.

Animals↗
PubMed1980

Bacterial meningitis after myelography.

Two cases opf bacterial meningitis due to streptococci occurred following Pantopaque myelography. These are, to our knowledge, the first reports of Streptococcus mitus and group G streptococcus causing meningitis in this situation. These 2 cases emphasize the importance of considering the possibility of bacterial meningitis following myelography and the difficulty in differentiating it on clinical grounds from the more common aseptic meningitis that occurs after myelography. They also emphasize the importance of maintaining strict sterile technique during myelography.

Adolescent↗
PubMed1979

Protective action of amiodarone against ventricular fibrillation in the isolated perfused rat heart.

The pretreatment of rats with amiodarone for 2 minutes to 3 weeks before the excision of their hearts caused a dose-related decrease in heart rate and an increase in the ventricular fibrillation threshold both before and after coronary arterial ligation. Similarly, amiodarone decreased the incidence of ventricular premature extrasystoles, ventricular tachycardia and fibrillation during the period of regional ischemia after coronary arterial ligation and also after reperfusion of the ischemic myocardium. There was no evidence of a metabolic protective effect on ischemic myocardium because tissue high energy phosphate content decreased to a similar extent in ischemic myocardium from control and amiodarone-treated rats. Instead, the protective effect of amiodarone against fibrillation was accompanied by attenuation of the increase in tissue cyclic adenosine monophosphate in ischemic myocardium after coronary arterial ligation. It is proposed that amiodarone exerts a potent antifibrillatory effect by decreasing tissue cyclic adenosine monophosphate in ischemic myocardium.

Amiodarone↗
PubMed1977

Treatment of fatal disseminated vaccinia virus infection in immunosuppressed mice.

Studies were performed to compare the therapeutic effectiveness of three antiviral drugs (ARA-A, ARA-C and IDU) on the course of fatal disseminated vaccinia virus infection in immunosuppressed mice. Treatment with ARA-A begun as late as 7 days after virus infection was significantly effective in preventing death; no antiviral effect of the other two drugs was demonstrated.

Animals↗
PubMed1972

Mechanism of recovery from systemic vaccinia virus infection. I. The effects of cyclophosphamide.

Administration of Cytoxan in doses capable of inhibiting both humoral and cellular immunity markedly potentiated primary systemic vaccinia virus infection in mice. Immunosuppressed mice did not form neutralizing antibody to vaccinia virus and had a prolonged and more severe viremia than nonimmunosuppressed control mice. Passive transfer of physiologic amounts of neutralizing antibody late in the course of infection, at a time when nonimmunosuppressed mice had similar levels of serum antibody, largely reversed the effect of Cytoxan on vaccinia virus infection. Transfer of 100 million immune spleen cells was much less effective than antibody in reversing the effect of Cytoxan on vaccinia virus infection, and mice receiving these cells did make some antibody. Serum interferon levels were not affected by Cytoxan. The results suggest an essential role for humoral antibody, but not for cellular immunity, in recovery from primary vaccinia virus infection in the mouse.

Animals↗
PubMed1972

Effect of an interferon stimulator, polyinosinic: polycytidylic acid, on experimental fungus infections.

IN THE PRESENT STUDY, THE ADMINISTRATION OF AN INTERFERON STIMULATOR, POLYINOSINIC: polycytidylic acid (In:Cn), increased the severity of both experimental Candida albicans and Coccidioides immitis infections in mice, as evidenced by earlier time of death and higher final mortality. In addition, kidney tissue levels of C. albicans at 3 and 5 days after infection were found to be about 40- to 300-fold higher in In:Cn treated mice than in control mice. Experimental Cryptococcus neoformans infection, however, was not significantly affected by In:Cn treatment.

Animals↗