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Biomedical subjects

M Woolley

Publications and source records attributed to M Woolley.

At least 19 recordsLinked to original sources
PubMed2003

Developing alternative devices to the long-term urinary catheter for draining urine from the bladder.

The self-retaining urinary catheter is used for long-term drainage of urine from the bladder only as a last resort because of serious associated complications, yet it remains a routine method for managing older and disabled patients with loss of bladder control. Blockage of the catheter from calcified deposits within its lumen is a common occurrence, obstructing the passage of urine and causing an urgent, unpredictable problem for patients, carers and the nursing staff. The need for further research on the subject has been recognized for many years. The SuPort Project aimed to develop an alternative suprapubic urine collection system. This report outlines the approach adopted towards the design and selection of the novel device, the production problems that ensued and the small clinical trial of a modified prototype.

Chronic Disease↗
PubMed2002

Urinary catheter 'deflation cuff' formation: clinical audit and quantitative in vitro analysis.

OBJECTIVE: To investigate reports from district nursing staff of difficulty in removing long-term urinary catheters (LTCs) because of the formation of a 'cuff' on deflating the self-retaining balloon. PATIENTS AND METHODS: Problems experienced by district nurses when removing urethral and suprapubic LTCs were audited, noting the type of problem, the catheter and any action taken. Quantitative in vitro studies were conducted on the deflated self-retaining balloons after incubating a similar range of catheters in saline at 37 degrees C for 6 weeks, using suprapubic profilometry to assess the resistance to withdrawal (retention force). RESULTS: Questionnaires were returned on 154 patients with LTCs; 56% had urethral and 44% suprapubic catheters. The catheters were hydrogel-coated (83%), all-silicone (13%) and PTFE-coated (3%). Twenty-two (14%) of the sample reported problems with catheter removal in the previous year, including 15 (68%) with all-silicone catheters and 15 (68%) with suprapubic catheters; cuff formation was noted in 60%. In the laboratory, 10 of the balloons formed a 'cuff' on deflation, but there was great variability in the effect this had on the retention force, with values of 0.5-3 N for different catheters. CONCLUSIONS: Most problems with catheter removal involved all-silicone and suprapubic catheters. Suprapubic profilometry confirmed increased resistance to withdrawal by formation of a 'cuff' on deflation of the balloon of all-silicone catheters. These results suggest that the first choice of catheter material for long-term urethral and suprapubic use should be hydrogel-coated latex.

Catheterization↗
PubMed1997

Animal rights.

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Animal Rights↗
PubMed1996

The challenge to medical research in a cost-competitive environment. Interview by Mark Harris.

As managed care and government actions threaten the financial base of research and education at America's teaching hospitals, they must find new sources of funds. Mary Woolley of the advocacy group Research!America notes that the heads of healthcare systems can help reverse the downward trend in funding and gain a competitive edge with the public, who favor spending more on research.

Academic Medical Centers↗
PubMed1992

You touched me.

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Female↗
PubMed1990

Duration of protective effect of terbutaline sulfate and cromolyn sodium alone and in combination on exercise-induced asthma.

For subjects with EIA participating in physical activities throughout the day, prolonged duration of protection is desirable. The purpose of this study was to determine whether in EIA a combination of the recommended aerosol doses of the beta 2-adrenergic receptor agonist, terbutaline sulfate (0.5 mg), and cromolyn sodium (disodium cromoglycate; 2 mg) provides longer protection against EIA than either drug alone. On four separate days, following the administration of either placebo, terbutaline alone, cromolyn sodium alone or terbutaline and cromolyn sodium together, 12 subjects (seven men and five women; aged 18 to 28 years) with EIA performed four identical eight minute treadmill runs, each separated by two-hour intervals. Drug treatments were given double-blind, with the order counterbalanced using a Latin-square design. Pulmonary function was recorded before the drug, immediately before and after exercise, and at 3, 4, 5, 6, 7, 10, 15, and 30 minutes after exercise. Inspired ventilation, heart rate, and environmental conditions were monitored during exercise. A two-way analysis of variance was performed to investigate the main effects of time and drug treatment. Results indicated that in comparison with placebo, EIA was significantly reduced by either cromolyn sodium or terbutaline administered up to two hours (p less than 0.01) and by the combination (cromolyn sodium and terbutaline) up to four hours after inhalation (p less than 0.05). No significant differences were found between the combination and terbutaline during the initial two hours (p less than 0.5). We conclude that a combination of beta 2-adrenergic receptor agonist and cromolyn sodium is the treatment of choice for prolonged effective protection from EIA.

Adolescent↗