Search PubMed⌕ Search

Biomedical subjects

M Wolman

Publications and source records attributed to M Wolman.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

Histochemical characterization of collagen fibers in fibrous overgrowth (irritation fibroma) of the oral mucosa: effect of age and duration of lesion.

In a study of 43 specimens of oral mucosa irritation fibroma, polarization colours of collagen thin (0.8 microm) and thick (1.6-2.4 microm) fibers were recorded in formalin-fixed and paraffin-embedded sections stained with Picrosirius red. Examination of polarization colours of both the 'thin' and 'thick' collagen fibers revealed an increase of yellowish-orange and orange fibers as a function of age in patients over 30 years old (P < 0.05 only in thick fibers). When the polarization colours of thin and thick collagen fibers were recorded as a function of duration of the lesion, there was an increase in the number of yellowish-orange and orange fibers and a decrease in blue-green and green fibers in both thin (P < 0.1) and thick (P < 0.05) populations as the lesion matured. These findings show that increments in both the patient's age and the duration of the lesions increase the amount of collagen fibers which exhibit yellowish-orange and orange polarization colours indicating tighter packing and better alignment of the microfibrils, similar to normal mature collagen. These differences may have an effect on the timing of the surgical excision.

Journal Article↗
PubMedDate not supplied

Basal membrane labyrinths in the healing stages of chick nutritional encephalopathy.

Chicks were fed a diet rich in oxidized oil and deficient in alpha-tocopherol. As soon as nutritional encephalopathy developed the animals were immediately put on to a normal diet, and kept alive for up to 166 days. Examination of the cerebellum showed multiple foci of healed encephalomalacia with EM appearance of basal membrane labyrinths between astroglial cells and around blood vessels. The possible origin of the basement membrane material in this conditions was considered and compared with similar formations in normal animals, in CNS tumour explants, and after portocaval anastomosis as well as after spinal cord lesions.

Animals↗