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Biomedical subjects

M Witte

Publications and source records attributed to M Witte.

49 records · Page 3Linked to original sources
PubMed1982

Dexamethasone suppressible hyperaldosteronism in a child with nephrosclerosis.

A 9 year old Mexican boy presented with severe hypertension, hypokalaemia and features suggesting acute glomerulonephritis. Nephrosclerosis was present on renal biopsy. Aldosterone levels were unresponsive to variations in dietary salt intake and plasma renin activity was suppressed. Following oral dexamethasone therapy (2 mg/day), plasma aldosterone decreased to undetectable levels, serum potassium normalized and plasma renin activity gradually increased. Dexamethasone also restored the normal responsiveness of the renin-aldosterone system to postural stimuli. The patient exhibited a marked response to a single dose of ACTH with a rise in plasma aldosterone. Long-term blood pressure control and normal potassium levels have been achieved with oral prednisone therapy (5 mg/day) for a period of one year. This case of dexamethasone suppressible hyperaldosteronism (DSH) illustrates that the degree of hypertension in this syndrome may produce severe renal microvascular lesions. DSH should be considered in all children who present with low renin hypertension.

Adrenocorticotropic Hormone↗
PubMed1981

Adrenal glomerulosa function in patients with dexamethasone-suppressible hyperaldosteronism.

The response of the adrenal glomerulosa to renin stimulation was determined in 10 patients with dexamethasone-suppressible hyperaldosteronism. The patients were treated continuously with 2 mg/day dexamethasone (DEX) and were studied on a regular sodium diet (87 meq/m2 . day) and on a 10 meq/day sodium diet. With DEX treatment all patients showed a prompt suppression of adrenal fasciculata function as evidenced by suppression of serum cortisol, corticosterone, desoxycorticosterone, and urinary 18-OH-desoxycorticosterone. The complete suppression of urinary pH 1 aldosterone (aldo) by DEX, unique to this disorder, was paralleled by a prompt suppression of urinary 18-OH-corticosterone. With continued DEX administration, plasma renin activity rose to the normal or supranormal range. Dietary sodium restriction resulted in a further rise in plasma renin activity and a rise in urinary pH 1 aldo and 18-OH-corticosterone. We conclude that in DEX-suppressible hyperpaldosteronism, although ACTH appears to be the primary stimulus for aldo secretion in the untreated state, when ACTH is suppressed, the adrenal glomerulosa responds normally to the stimulation of renin-angiotensin II.

18-Hydroxycorticosterone↗
PubMed1978

[Measurements of the temperature during the use of dental ultrasonic devices].

This investigation worked at temperature measurements in cylindric pieces of copper for determination of surface temperatures and in root dentin of calves using ultrasonics by varying intensity, water flowing and pressure. In each experiment two different dental ultrasonic devices were used with two tips. The experiments with sufficient water flowing showed that the spray temperature which was determined separately in further experiments influenced the measurements mainly. On the other hand an insufficient water flowing resulted in remarkable findings showing for example temperatures in the pieces of copper higher than 195 degrees C and macroscopic changes on the root surface in form of carbonization and alterations of cementum and root dentin.

Animals↗
PubMed1976

Effects of sex hormones and of pregnancy on the selenium metabolism.

In order to obtain information about the hormonal regulation of the selenium metabolism, the element level in the blood serum of rats was determined by means of neutron activation analysis after administration of sex hormones and during pregnancy. While the decreases in the mean selenium concentrations found after the treatment with progesterone and progesterone + estrone were too low to enable us to establish response patterns, marked changes were observed in the serum of gravid rats. Here the selenium level dropped significantly (P less than 0.001) by 25% between the 10th and 15th day of gestation.

Animals↗
PubMedDate not supplied

Care of the at-risk neonate born at home. A model for nurse-midwife/physician collaboration.

Because certified nurse-midwives (CNMs) who practice in the home lack the structure and boundaries provided in an institution, they must provide the elements of a safe environment for their practice, both physical and intangible. The relationship between the CNM who practices in the home and the physician(s) with whom s/he collaborates when women or neonates experience complications beyond the scope of nurse-midwifery practice is a critical element of this structure. This paper describes models for collaborative care for home birth, outlines the process of developing a collaborative practice agreement, and discusses specific factors to consider when forming a relationship. The care of the compromised home-birth neonate is developed as a model for collaborative practice. The paper discusses identification of the home-birth neonate requiring collaborative care, the preparation for potential newborn complications, and the initiation of emergency measures to be taken by the CNM when such a complication occurs.

Emergency Medical Services↗