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Biomedical subjects

M Witkowska

Publications and source records attributed to M Witkowska.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Biochemical indicators of coronary arteriosclerosis].

In 251 patients undergoing cardiac catheterization, plasma levels of lipids, lipoproteins, apoproteins and nonlipid risk factors as fibrinogen, fibrinolysis time, glucose and uric acid in blood were correlated with the incidence and severity of coronary artery disease (CAD). There were significant differences between CAD group and controls and between men and women with CAD with respect to the mean lipid values. Among the nonlipid risk factors fibrinogen concentration in CAD patients was significantly higher than in controls. In univariate analysis in men, score for the severity of atherosclerosis was strongly related to the apoB and LDL concentration, less to the HDL and fibrinogen levels and to ratios of total cholesterol/HDL and LDL/HDL. In women severity of the disease correlated with apoB, fibrinolysis time, fibrinogen and triglyceride levels. By stepwise multivariate analysis, in both men and women, apoB was selected as the best discriminator between CAD patients and controls. The results of the study indicate that the levels of apoB may be a more accurate predictor of the severity of CAD than the other biochemical risk factors. The presented data also suggests an association between increased fibrinogen concentration, reduced fibrinolytic capacity and CAD. The values of apoB and fibrinogen as indicators of cardiovascular risk should be assessed in prospective studies.

Adult↗
PubMed1991

[Does chronic therapy of hypertension with acebutolol or hydrochlorothiazide effect coronary risk factors?].

In 78 patients with mild or moderate hypertension, effect of acebutolol and hydrochlorothiazide on plasma lipids, lipoproteins, fibrinogen and plasma fibrinolysis time were investigated. 42 patients were treated with acebutolol for 18 months and 36 with hydrochlorothiazide for 24 months. It was shown that neither acebutolol nor hydrochlorothiazide induced significant alterations in investigated biochemical risk factors. The possible causes of controversy encountered in literature and analysis of factors which may influence the character and severity of metabolic disorders resulting from antihypertensive therapy were discussed.

Acebutolol↗
PubMed1989

[Effect of long-term treatment with propranolol or hydrochlorothiazide on biochemical risk factors of coronary disease in patients with hypertension].

In 59 patients with mild or moderate essential hypertension effects of propranolol and hydrochlorothiazide on serum lipids, fibrynogen, glucose and uric acid concentrations as well as serum euglobulins fibrynolysis time were studied. 36 patients received propranolol and 23 subjects hydrochlorothiazide. Follow-up time was 1 year. Statistically significant increases of serum triglycerides, fibrynogen, levels and total cholesterol/HDL cholesterol LDH/HDL indices in comparison with their initial values were stated in a propranolol group. Significant serum cholesterol increase after 6 month therapy was the most substantial metabolic change in a hydrochlorothiazide group. Alterations of lipids indices in both groups were especially intensive in patients with pretreatment stated disturbances of lipids metabolism.

Adult↗
PubMed1983

Pharmacological properties of new heterocyclic derivatives of 1,5-benzodiazepine.

Sixteen new heterocyclic 1,5-benzodiazepine derivatives (compounds AN8-AN24) were screened for their central action. Compounds AN8-AN10 and AN17 strongly antagonized the action of pentetrazol, compounds AN10, AN14-AN17 and AN22 had potent antiserotonin properties, and compounds AN10, AN19, AN20 and AN23 markedly potentiated the action of DOPA.

Animals↗
PubMed1979

Central action of new imido derivatives of succinic acid.

New imido derivatives of succinic acid were screened pharmacologically with regard to their influence on the central nervous system. No relation was found between the character and position of substituents and depressant action on the CNS. However, it was remarked that potentiation of the central influence of DOPA probably depends on the position of the p-chlorophenyl group.

Amphetamine↗
PubMed1979

Central action of new derivatives of tetrahydropirimidinedione-4,6.

The central action and LD50 of 11 new 2,5-substituted derivates of tetrahydropirimidinedione-4,6 with an aryl group at C2 were investigated. The most favorable action was exerted by 2-furfurylamine derivatives with an alkil or benzyl group at C5. These compounds acted in doses of 0.0025--0.01 of their LD50 synergistically with chloral hydrate and strongly with hexobarbital, delayed convulsions induced with pentetrazole and potentiated the central action of DOPA in mice pargyline-inhibited MAO activity. They did not antagonize electrogenic convulsions, amphetamine potentiated motility and the action of reserpine, and had no analgetic action. Their LD50s were 670-- 1660 mg/kg.

Amphetamine↗