Search PubMed⌕ Search

Biomedical subjects

M Wiseman

Publications and source records attributed to M Wiseman.

26 records · Page 2Linked to original sources
PubMed1980

[Contralateral stapedial reflex in children, adults and high-frequency loss hearing impaired patients (author's transl)].

Contralateral stapedius reflexes were measured in 332 patients. Results were analysed and statistically checked with regard to amplitude, slope of reflex in the recovery phase and partial and total reflex area. The results seem to indicate that none of the measure parameters have any direct diagnostic value. Optimal results measuring contralateral stapedius reflex are to be expected at 1000 Hz.

Acoustic Impedance Tests↗
PubMed1979

Open-access endoscopy service for general practitioners.

An open-access general-practitioner referral service for endoscopy of the upper gastrointestinal tract was established in a district general hospital, and the impact of the service over three years was assessed. The reason for referral, duration of symptoms, and amount of disease detected were the same in patients referred by general practitioners and those attending from hospital outpatient departments. Despite a steady increase in the number of patients referred for endoscopy, the number of barium-meal examinations performed did not correspondingly decrease. The number of ulcers and cancers detected in each six-month period of the study did not increase, and the combined overall pick-up rate for these two conditions fell from 25% to 13%. All general practitioners in the area were sent questionnaires. Most thought that clinic referral had been reduced and patient management helped as a result of the introduction of the service. While the value of negative endoscopic findings cannot be assessed, there is little objective evidence of benefit. Hence the large increase in numbers of endoscopies performed as a result of the introduction of the service cannot be justified.

Diagnostic Services↗
PubMed1979

Axonal transport of actin in rabbit retinal ganglion cells.

We labeled proteins in the cell bodies of rabbit retinal ganglion cells with [35S]methionine and subsequently observed the appearance of radioactive actin in tissues containing the axons and synaptic terminals of these neurons, i.e., the optic nerve (ON), optic tract (OT), lateral geniculate nucleus (LGN) and the superior colliculus (SC). The temporal sequence of appearance of labeled actin (which was identified by its specific binding to DNase I, its electrophoretic mobility, and its peptide map) in these tissues indicated that actin is an axonally transported protein with a maximum transport velocity of 3.4--4.3 mm/d. The kinetics of labeling actin were similar to the kinetics of labeling two proteins (M1 and M2) which resemble myosin; these myosin-like proteins were previously found to be included in the groups of proteins (groups III and IV) transported with the third and fourth most rapid maximum velocities. The similarity in transport between actin and myosin-like proteins supports the idea that a number of proteins in the third and fourth transport groups may be functionally related by virtue of their involvement in a force-generating mechanism and suggests the possibility that these proteins may be axonally transported as a preformed force-generating unit.

Actins↗
PubMedDate not supplied

Bullous cellulitis caused by Serratia marcescens.

Bullous cellulitis is a distinctive form of cellulitis most often caused by beta hemolytic streptococci. This report describes a case of bullous cellulitis caused by Serratia marcescens in an elderly diabetic woman with peripheral vascular disease. A discussion of this ubiquitous, nosocomial pathogen follows.

Aged↗