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Biomedical subjects

M Williamson

Publications and source records attributed to M Williamson.

At least 109 records · Page 6Linked to original sources
PubMed1982

Therapist perceived client social role dimensions of psychotherapeutic processes.

Therapist and client social role dimensions of therapy are important considerations in the rehabilitation process. The purpose of the present investigation was to determine therapist perceived client social role dimensions of psychotherapeutic processes. It was also conducted to find out their nature and frequency. Results indicated the most frequently perceived dimensions were: performance, ambiguity, strain, conflict and immersion.

Attitude of Health Personnel↗
PubMed1981

The distribution of copper in sickling erythrocytes as determined by an IBM cell separator.

Elevated levels of copper have been found in sickling erythrocytes. Since this copper may inhibit sickling or induce hemolysis the authors decided to investigate the distribution of copper in sickling erythrocytes to gain some insight into its origin. When samples of sickling erythrocytes were fractionated by density gradient centrifugation with an IBM cell separator and the fractions analyzed for copper, it was found that the copper to hemoglobin ratio of the different fractions varied several fold. This finding indicated that the copper in sickling erythrocytes did not equilibrate with the copper in serum or other cells and that the copper was present in the cells when they were released into the blood stream. When erythrocytes were obtained from a sickle cell patient four days post-crises, a large amount of residual copper could be observed in the first (youngest) fraction. It was suspected that this copper was in mitochondrial residues. It was also observed that copper levels tended to be higher in control and sicklings erythrocytes during the winter months. The predominance of the first fraction in samples of sickling erythrocytes taken during the winter months suggests that the turnover of sickling erythrocytes is accelerated at this time.

Adult↗
PubMed1979

Physical growth in phenylketonuria: II. Growth of treated children in the PKU collaborative study from birth to 4 years of age.

Height, weight, and head circumference data up to age 4 years are reported for 124 children with phenylketonuria (PKU) who had been started on diet management before 4 months (121 days) of age and who were participating in the Collaborative Study of Children Treated for Phenylketonuria. Growth measurements of both the children and their parents corresponded with national and international standards. The growth of children with PKU was compared also with that of a group of normal children in the United States in whom corresponding longitudinal growth data had been obtained at the Fels Research Institute (FRI). Statistically significant differences betweeen the groups were not noted at any age. However, when these groups were compared on coefficients using curve fitting, a trend toward a greater increase in weight as they became older, noted in both sexes in the PKU study group, was significantly higher (P less than .005) in the PKU study girls compared with the FRI sample. Height growth was identical in both groups, and comparison with family data showed that the children with PKU grew as expected for their genetic endowment.

Body Height↗
PubMed1978

The high school nurse practitioner.

Better problem identification and improved access to community health care were the result of changes made during the past three years in a traditional urban high school health service. The first change included training the nurse to become a pediatric nurse practitioner and adding a full-time health aide. The other change included the use of clinic management forms developed by the nurse practitioner/health aide team to be used for three common student complaints: headache, stomachach and upper respiratory symptoms. Our experience indicates that out-of-school referrals for medical care doubled, and more students referred received care after these changes were instituted. The high school pediatric nurse practitioner counsels students in understanding their health problems and in making decisions about their health care. She also coordinates educational and health resources and provides psychosocial support for students.

Adolescent↗
PubMed1978

Methods of dietary inception in infants with PKU.

Information on methods of initiating the phenylalanine-restricted diet was obtained from the medical personnel of sixteen clinics in the Collaborative Study of Children Treated for Phenylketonuria. The four dietary methods used initially to lower serum phenylalanine were: Normal dilution Lofenalac, Lofenalac, with phenylalanine added as milk, Lofenalac with milk added to provide 200 mg. phenylalanine per day, and alternating bottles of normal dilution Lofenalac and cow's milk during the first four days of therapy. During the first week of treatment, eight clinics obtained serum phenylalanine determinations daily or every other day. The nutritionist prescribed the phenylalanine-restricted diet following diagnosis in nine of the clinics. In most clinics, the nutritionist was responsible for obtaining information relating to dietary management and follow-up contacts during the first month of treatment. The initial dietary instruction was accomplished in most clinics by a combination of lecture/discussion/demonstration methods. Both parents attended the initial dietary instruction in thirteen clinics. Neither the professional person(s) nor the method of initial dietary instruction, if detailed and comprehensive, made any difference in control of serum phenylalanine during the first year of life.

Dietary Proteins↗
PubMed1977

Nutrient intake of treated infants with phenylketonuria.

Growth, energy, and nutrient intake of 88 treated infants in the Collaborative Study of Children Treated for Phenylketonuria were evaluated longitudinally and compared to normative data and by treatment group. Growth parameters (height and weight) did not differ according to treatment group assignment, nor did they differ from normative data. Subjects in treatment group 2 had a significantly higher intake of phenylalanine than did subjects in treatment group 1. Differences in intake of other nutrients disappeared when intake was compared on an energy or body weight basis. Differences in intake by males and females also disappeared when compared on an energy and a body weight basis. From none to 10% of the subjects had energy intakes below two-thirds of the 1968 Recommended Dietary Allowances (RDA). Low individual energy intakes were more commonly found in the first and fourth quarters, and only during the first quarter of infancy did mean energy intake meet the RDA. From 48 to 80% of subjects had intakes of preformed niacin below two-thirds of the 1968 RDA. Few subjects had low intakes of protein, iron, or vitamin A, and intakes of all subjects were greater than 67% of the RDA for calcium, phosphorus, thiamin, riboflavin, and ascorbic acid. It is suggested from the data presented that a supplemental casein hydrolysate supplies adequate essential amino acids and nitrogen to support normal growth in infants when protein and energy intakes are fed at the levels described.

Body Height↗
PubMed1977

Collaborative study of children treated for phenylketonuria: study design.

Studies that have attempted to test the effectiveness of treatment in phenylketonuria (PKU) have been handicapped by small samples due to rarity of the disorder and inadequate control of other sources of error. The present study was designed to overcome these limitations by treating a large number of children with PKU under controlled conditions from near birth to 6 years of age. Nineteen medical centers in 13 states have participated in the study, which is currently in progress. This article is one of a series of final reports. It describes the study design and sampling procedures employed to answer questions of interest for which results will be reported in subsequent articles. The study serves as a model for future collaborative investigations of a similar nature.

Child↗
PubMed1976

A computerized procedure for estimating nutrient intake.

A procedure was devised for computing intake in terms of calories, total protein, phenylalanine, carbohydrate, and fat. The procedure used a magnetic tape containing 3,122 numbered food items. The nutrient composition of each food was reported for 100 g of the edible portion of the food. In addition, diet diaries were prepared in which the foods eaten during the preceding 24-hr period, the code for each food corresponding to the number for the same item on the magnetic tape, and the number of units of each food eaten were recorded. A computer program then was written that calculated the amounts of intake per day for each nutrient. Application of the procedure for 42 consecutive days on the daily diet records of 43 adult carriers of the phenylalanine hydroxylase enzyme formed the data base used to determine if aspartame significantly increased levels of phenylalanine in the blood. Adaptations of the procedure permit calculations of intake for periods from 1 to 30 days and analyses of additional nutrients including calcium, phosphorous, iron, vitamin A, thiamine, riboflavin, niacin, and ascorbic acid.

Computers↗
PubMed1976

Intellectual performance of 36 phenylketonuria patients and their nonaffected siblings.

Thirty-six patients with a confirmed diagnosis of phenylketonuria (PKU) were identified and placed on dietary therapy before reaching 121 days of age. These children are currently between 4 and 6 years old, and have been given the Stanford-Binet Intelligence Scale. Subsequently, their normal siblings of closet age were selected as matched-pair controls and were also tested with the Stanford-Binet. The mean age of the PKU sample when tested was 50.0 months, and 50.9 months for the normal controls. The 36 index patients scored a mean IQ of 94 and their nonaffected siblings obtained a mean IQ of 99. This five-point mean difference was significant at the .02 level, and suggests the presence of a minimal intellectual impairment associated with PKU, even when treatment begins early and is rigorously monitored.

Adolescent↗