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Biomedical subjects

M Wilcox

Publications and source records attributed to M Wilcox.

At least 91 records · Page 5Linked to original sources
PubMed1980

A monoclonal antibody specific for diploid epithelial cells in Drosophila.

Results from various experiments suggest that the cell surface has an important role in development. However, there is relatively little information on the specific surface molecules involved in developmental processes. In an effort to characterize cell-surface components that may be involved in Drosophila development, we have been making monoclonal antibodies against D. melanogaster imaginal disks. The holometabolous insects are unusual in that scattered among the larval tissues are groups of undifferentiated imaginal cells which, during metamorphosis, will form most of the adult insect. The imaginal disks, which we use as an immunogen, are hollow sacs of cells; each disk will form a specific part of the adult cuticle. Other imaginal cells are found as nests or rings in various larval organs. We describe here results indicating that one of the clones we have isolated, DA.1B6, makes an antibody against an antigen which, in larvae, is generally restricted to the undifferentiated sheets of imaginal epithelial cells. This and other results indicate that the antigen is specific for the diploid epithelia in Drosophila.

Animals↗
PubMed1976

Measurement of an inhibitory zone.

An inhibitory zone mechanism generates the heterocyst pattern in Anabaena. These inhibitory zones can be measured; we find that they extend about five cells on either side of a heterocyst. We can use our observations to predict with reasonable accuracy which cells in the filaments will differentiate into heterocysts.

Cell Differentiation↗
PubMed1975

Mutants of Anabaena cylindrica altered in heterocyst spacing.

Nitrosoguanidine induced mutants of Anabaena cylindrica have been obtained, which are altered in heterocyst spacing. In the wild type organism the pattern is composed of single intercalary heterocysts. The mutant patterns fall into several classes: those with only terminal heterocysts, with both terminal and intercalary heterocysts, with groups of heterocysts and those totally lacking heterocysts. The mutants are described in detail, and the various pattern modications are interpreted in terms of a model we have proposed.

Ammonia↗