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M Wiese

Publications and source records attributed to M Wiese.

At least 109 records · Page 6Linked to original sources
PubMed1986

[Long-term analysis of non-A, non-B hepatitis--clinical, histologic and immunologic findings].

By means of a long-term analysis of histological and clinical-biochemical data taken of a group of patients (n = 38) having contracted an acute viral hepatitis non-A, non-B with a uniform parenteral source of infection evidence is given concerning the dynamic processes in the course of chronic non-A, non-B hepatitis. The analysis was therefore not based on the total biopsy material but on a section of 143 liver biopsies of patients who had been punctured at least 3 times (up to 6 times) in the 7 years of examination. A rate of 57,2% chronic persistent and 42,8% chronic lobular hepatitis was ascertained. A chronic active hepatitis or liver cirrhosis were not found. Both the histological activity degrees and ALAT-mean values were declining during the follow-up study though attacks (ALAT) and histological reactivations were observed in the 7th year, too. The data suggest that the chronic liver changes that developed in this type of non-A, non-B hepatitis proved to be extremely lingering but as a whole a regressive tendency could be observed.

Adult↗
PubMed1985

[Acute viral hepatitis and body loading--a self-excluding therapeutic principle?].

Of 27 patients with acute virus hepatitis 16 patients performed successfully a daily training programme during their stay in hospital. On the basis of both clinical and clinical chemical parameters in comparison to the control group of 10 patients who observed the conventional rest in bed the course of healing did not deteriorate. Also with regard to the late prognosis no higher rate of recidivation or chronification could be proved. Our examinations support the thesis that the demand of strong rest in bed is to be regarded as out of date in the treatment of acute virus hepatitis.

Adult↗
PubMed1985

[Virus-associated chronic autoimmune aggressive hepatitis (HBsAg seronegative) with pronounced diarrhea].

It is reported on a 17-year-old male patient who in 1982 fell ill with a HBsAg-seronegative hepatitis with therapy-resistant diarrhoeas of high frequency and in whom immunohistologically a virus-associated autoimmune chronic aggressive hepatitis was established. As cause of severe diarrhoeas which underwent involution only after 2 months as a sequel of the azathioprin-prednisolone therapy the proof of HBsAg in Lieberkühn's crypts of the small intestine performed by means of direct immunofluorescence is assumed.

Adolescent↗
PubMed1985

[Behavior of immunoglobulins in non-A/non-B hepatitis--a contribution to prognostic evaluation].

It is reported on immunoglobulin long-term courses in 107 female patients with non-A/non-B-hepatitis. There were statistically significant differences between the group with healing (n = 35) and the group with chronic persisting hepatitis (n = 70) in the IgG- and IgA-values. The immunoglobulin courses in the chronic aggressive hepatitides (n = 2) were not statistically evaluated on account of the small number of cases. It is concluded (in analogy to the investigations of the behaviour of immunoglobulins in hepatitis B) that particularly the IgG course analysis is suitable to reveal the chronification of the non-A/non-B-hepatitis prognostically with high probability.

Adult↗
PubMed1985

[Is chronic persistent hepatitis decidedly benign?].

Issuing from an analysis of the subjective and objective findings as well as of social data of 77 patients with histologically ascertained chronic persisting hepatitis after virus hepatitis non-A/non-B the problem is pursued whether or not - as in literature is nearly homogeneously assumed - the chronic persisting hepatitis is a decidedly benign disease. Apart from the difficulties in the clear histological classification mentioned by other authors it seemed to be profitable to demonstrate in detail the impairments by persisting symptoms which are to be established in the 5th year of the disease (75% of the patients), by acute attacks (ALAT max. 6.9 mymol/1 . s) with corresponding disabilities (40% of the patients) and the effects on social and professional life. The chronic persisting hepatitis is a very heterogeneous group, which must be considered more differentiated concerning the value of the disease and the prognosis. In this case the etiology must apparently more be taken into consideration, for the findings demonstrated in the 5th year of the disease of the chronic persisting hepatitis (non-A/non-B) show only partly (quoad vitam) a benign prognosis.

Adult↗
PubMed1985

[Histomorphologic picture of chronic non-A, non-B hepatitis].

Basing on several international studies on the light microscopic pattern of acute non-A, non-B hepatitis we tried to discover the histological criteria of its chronic course by means of a detailed analysis of 181 liver biopsies of 94 patients suffering from chronic non-A, non-B hepatitis (a homogeneous group without competing noxious agents). In accordance with the relevant literature we found a rate of chronic courses of about 60% with chronic persistent hepatitis (2/3) and chronic lobular hepatitis (1/3) predominating. A transition into liver cirrhosis was not stated. As changes typical of the chronic non-A, non-B hepatitis cell ballooning (89%), changes of cell nuclei (88%), eosinophilic changes of cytoplasm (73%), focal sinusoidal cell activation (92%) and microvesicular steatosis (59%) were ascertained with the chronological analysis showing that there were no changes of these criteria up to the 6th year of disease. Its cause is seen in an incomplete elimination of the hepatitis viruses as a result of inefficient immune defence.

Adult↗
PubMed1985

[Risk-benefit relation of liver biopsy in unclear jaundice].

On the basis of an analysis of 125 liver biopsies in cases of unclear jaundice (mean bilirubin level 96 mumol/l, mean level of AP 1,78 mumol/l X s, of gamma GT 8,48 mumol/l X s, biopsy on an average on the seventh day of jaundice) the relation of risk and benefit of a liver biopsy is assessed. The benefit of the intervention being carried out with small expenditure of material and time and with minimal stress for the patients consists above all in the praeoperative exclusion of hepatitis and in the proof of cholestatic liver parenchyma diseases, which should not be operated on. In contrast to other authors no increased risk of the percutaneous liver biopsy during the first 10 (-14) days of jaundice (independent of the level of biochemical parameters of cholestasis) was stated (no biliary peritonitis, lethality rate 0%). The modern procedures of direct cholangiography are not seen as competing methods of examination but as such complementing each other with the liver biopsy.

Adult↗
PubMed1984

[Hepatic coma in fulminating viral hepatitis--treatment results in 1981 in a district hospital].

n the basis of clinical case reports on liver disintegration comata in foudroyant virus hepatitis the coma therapy was explained which was performed in the clinic for infectious and tropic diseases of the County Hospital St. Georg Leipzig in 1981 and this therapy was compared with the possibilities mentioned in literature. The aim of the article was to determine the present position of a county hospital in the great number of forms of therapy proposed. The basic therapy aimed at the reduction of neurotoxic protein metabolites and the application of intensive-medical therapeutic methods in interdisciplinary cooperation of internal specialist, specialist in dialysis and haemostaseologist are valuated as successful. The combined haemoperfusion/haemodialysis--two out of three patients treated survived--as a constituent of the present concept of therapy is assessed positively.

Adult↗
PubMed1983

[Effect of a bicycle ergometry training program in the acute phase of viral hepatitis on its late prognosis].

37 patients with clinically and histologically ascertained acute virus hepatitis (51% virus hepatitis B) underwent a bicycle-ergometric load a short time after admission to hospital and 17 of them were subsequently submitted to a training from twice a day to 30 minutes with 70% of the submaximal steady state effect. After their discharge from hospital all patients were repeatedly examined in the outpatient department for on an average 2.7 years; 20 patients (8 in the load group, 12 in the comparative group) were submitted to a liver biopsy on an average after one year. In 11 of the other patients the result of a histological examination of the liver from the end of the clinical treatment was present. The comparison of the training group and the control group showed nearly the same percentage of cures for the two groups as well as no transitions into chronic hepatitis in the training group. Also clinical and biochemical relapses did not appear in the load group. In a follow-up observation up to five years in the training group did not appear any disadvantage concerning the complete cure of virus hepatitis so that we apparently do not fear any negative sequels of physical activity in the acute phase of virus hepatitis. A forced immobilisation of the body--after proved ineffectiveness of diet and medicamentous treatment last support of the therapeutic regime--thus seems no more be indicated, since it is also accompanied by impairing reduction of the bodily function.

Acute Disease↗
PubMed1980

[Biliary diseases among patients in an infection clinic].

The result of the analysis of dismissal diagnoses of patients who were admitted to the clinic for infectious diseases of the district hospital St. Georg Leipzig with suspicion of hepatitis was that in about 20% of the patients a benign disease of the biliary ducts was present. The false admission of cases with diseases of the biliary ducts into the clinic for infectious diseases was doen not only --as it were to be expected-- by general practitioners which had no laboratory capacities, but above all by specialists of larger outpatients-departments who had performed laboratory examinations and also by larger hospitals for internal or surgical diseases. Main cause of this unfavourable result is the relative overvaluation of an established aminotransferase activity. In 59% of our cases the correct diagnostic coordination could have been possible already in the basal diagnostics, taking into consideration the high value of the anamnesis.

Adult↗
PubMed1979

[Cholestatic hepatosis caused by Talinolol (Cordanum)?].

It is reported on a 38-year-old female patient who was treated for 18 days with 150 mg cordanum (talinolol) each and then fell ill with a dyspeptic clinical picture and signs of cholestase. The result of a liver biopsy was the picture of a cholestatic hepatosis. According to the results of the lymphocyte transformation test and the monocyte test as well as to the reexposition with following clinical recidivation the talinolol medication is to be regarded as cause. Pathogenetically is referred to the structural relations of talinolol to substances with paragroups as well as to a possible summation of different loads of the liver function.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

[Computer-assisted navigated acetabulum placement in hip prosthesis implantation--application study in routine clinical care].

AIM: This study serves to examine the feasibility of a CAS system in clinical routine use in the field of total hip replacement. METHOD: Within a prospective study 70 total hip replacements were performed by one surgeon (KB) between March and November, 1999 using a CAS system for preoperative planning and intraoperative cup placement. RESULTS: The average operating time was 70 min. This means an average increase in total time of operation about 15-20 min. The average blood loss was 630 ml. No additional specific complications due to the use of the system were seen. There was no additional trauma created by percutaneous pointing at the spina or flxing a dynamic reference base (DRB) at the pelvis. CONCLUSION: The active application of this CAS system in clinical routine use showed very good results in feasibility and can be considered as reliable. The navigated cup placement shows the potential of improving the results in cup placement, thus improving the outcome of hip arthroplasty.

Acetabulum↗
PubMedDate not supplied

[Using the CAS (computer-assisted surgery) system in arthroscopic cruciate ligament surgery--adaptation and application in clinical practice].

AIM AND METHOD: The anterior cruciate ligament (ACL) is of great importance for the knee joint function. In the case of a complete ligament injury there is hardly any chance for complete recovery. The clear advantages of an operative reconstruction by replacing the ACL has been shown in many trails. The accurate placement of the graft's insertions has a significant effect on the mid- and probably long-term outcome of this procedure. Reviewing the literature, there are poor long-term results of ACL replacement in 5 to 52% of all cases, depending on the score system. One of the main reasons for unacceptable results is graft misplacement. This led to the construction of a CAS system for ACL replacement. The system assists this surgical procedure by navigating the exact position of the drilling holes. The Potential deformation quantity of the transplant can be controlled by this system in real time. RESULTS: 40 computer-assisted ACL replacements have been performed under active use of the CAS system. The short-term results are encouraging, no special complications have been seen so far. Prospective long-term follow-up studies are ongoing. CONCLUSION: ACL reconstruction by manual devices has many sources of error. The CAS system is able to give the surgeon reasonable views that are unachieveable by conventional surgery. He is therefore able to control a source of error and to optimise the results. The feasibility of this device in clinical routine use has been proven.

Anterior Cruciate Ligament↗