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Biomedical subjects

M Wierup

Publications and source records attributed to M Wierup.

At least 37 records · Page 2Linked to original sources
PubMed1984

The effect of feeding diets containing avoparcin and monensin on the occurrence of Salmonella in caecum and liver in experimentally infected chickens.

In two experiments (Experiments A and B) chickens experimentally infected with S. infantis at 7 days of age and fed diets containing both avoparcin (10 ppm) and monensin (90 ppm) showed a higher frequency of Salmonella-positive livers and higher caecal counts of Salmonella 1 and 2 weeks after challenge than similarly infected chickens fed only avoparcin (10 ppm). The results may indicate a synergistic action between the two drugs on the ability of chickens to withstand Salmonella infections.

Animals↗
PubMed1982

Evaluation of a killed feline panleukopenia virus vaccine against canine parvoviral enteritis in dogs.

Immunogenic potency of a killed feline panleukopenia virus vaccine against canine parvoviral enteritis in dogs was examined. The vaccine elicited hemagglutination-inhibition antibodies to canine parvovirus (CPV) in all of the 72 dogs which were vaccinated. The vaccine was protective in dogs against both experimentally induced and naturally occurring CPV-induced disease. By statistical analysis, 4 weeks was found to be the optimal spacing between 2 vaccinal doses resulting in hemagglutination-inhibition antibody titers up to 1:5,120. Adverse reactions to the vaccine were not observed. Atypical lymphocytes were found consistently in the CPV-infected control dogs.

Animals↗
PubMed1981

Concomitant occurrence of Campylobacter and parvoviruses in dogs with gastroenteritis.

In 1979 a canine parvovirus infection was widespread among dogs in Sweden. During the epizootic faecal samples were taken for bacteriological examination from 77 hospitalised dogs at an animal clinic. Forty-nine of the dogs had signs of gastroenteritis and they were all infected with canine parvovirus according to serological investigations. The remaining 28 dogs were referred to the clinic for other reasons. Campylobacter was isolated from 23 out of the 49 dogs with gastroenteritis and from 4 out of 28 dogs lacking symptoms of enteritis. The significance of these findings is discussed.

Animals↗
PubMed1981

Bacteriologic examination of equine fecal flora as a diagnostic tool for equine intestinal clostridiosis.

The fecal flora of 56 clinically healthy and 23 sick horses were examined bacteriologically for counts of Clostridium perfringens, molds, coliforms, alpha- and beta-hemolytic streptococci, and microbes belonging to genus Bacillus, as well as for the presence of Salmonella spp. Of the healthy horses, 85.7% had a C perfringens count less than 10(1) colony-forming units/g of feces. Of the healthy horses, lowest counts were found in race-horses. Of the sick horses, equine intestinal clostridiosis was diagnosed in 2 horses with large C perfringens counts (10(4) to 10(7) colony-forming units/g) and with acute diarrhea. The 7 isolates of C perfringens were identified as serotype A. Salmonella spp were not detected from any of the horses. The study indicated that diagnosing equine intestinal clostridiosis based on the determination of the fecal C perfringens count was suitable.

Animals↗
PubMed1979

Epidemiological investigation of an animal house based upon phage-typing and biotyping of Staphylococcus epidermidis.

The value of biotyping and phage-typing coagulase-negative staphylococci in the epidemiological investigation of a laboratory animal house was clearly demonstrated. In the animal rooms in which conventional bacteriological methods revealed equal bacterial contamination between a conventional unit and one housing specified-pathogen-free rodents, biotyping identified Staphylococcus cohnii as the only species in the latter, compared to S. warneri, S. hominis, S. saprophyticus. S. xylosus abd S. epidermidis as well as S. cohnii in the conventional unit. Similarly, phagetyping revealed 2 phage types in the specified-pathogen-free compared to 7 in the conventional unit. Thus biotyping and phage-typing provided evidence for the existence of a barrier between these units that had presented similar gross bacteriological findings.

Animals↗
PubMed1979

Bacteriological examination of a modern animal house containing small laboratory animals.

Floors and other areas totalling 1800 m2, comprising conventional and specified-pathogen-free (SPF) units, were screened bacteriologically 6 times in a year. The contamination indices observed were lower within than outside the units, and lower in the SPF than in the conventional unit. Bacterial counts in rooms containing animals in the conventional and SPF units were very similar. In all of the areas investigated within the units, most of the samples revealed less than 2 colony forming units per cm2. In contrast, high degrees of bacteriological contamination were detected in the changing rooms after showering or washing before entry. Staphylococcus epidermidis was the dominant bacterial species isolated. The bacteriological spectrum did not vary between the areas surveyed.

Animals↗
PubMed1979

Antibiotic resistance and transferable antibiotica resistance Escherichia coli isolated from calves on a modern farm with therapeutic problems and unsatisfactory management conditions.

On a farm with therapeutic problems and unsatisfactory management conditions, the occurrence of antibiotic resistance and transferable antibiotic resistance has been studied in E. coli isolated from calves which were 5 and 30 days old. Strains with resistance to up to seven antibiotics as well as transferable resistance against up to five antibiotics were recorded. On an average, 4.2 strains with different patterns and 4.0 different strains with transferable resistance were isolated from each calf. The corresponding figures previously found for healthy control calves were 1.6 and 1.1 strains, respectively. Resistance and transferable resistance were most common against sulphonamide and penicillin.

Animals↗
PubMed1978

Production of coagulase, deoxyribonuclease and heat-stable deoxyribonuclease by canine isolates of staphylococci.

Staphylococci isolated from different infections in dogs have been investigated for production of coagulase, deoxyribonuclease (DNase) and heat-stable DNase. Alll coagulase-positive strains (220) also produced DNase and heat-stable nuclease. However, 4 out of 15 coagulase-negative strains were also positive in both the DNase and the heat-stable DNase tests. Several tests for DNase and heat-stable DNase were evaluated. No strains were DNase-positive, heat-stable DNase-negative, or vice-versa.

Animals↗
PubMed1977

[Postoperative staphylococcal infection as a late complication following treatment of pseudarthrosis (author's transl)].

The study describes a case of postoperative infection following surgery of a humeral pseudarthrosis in a dog. The infection was manifested by fistulas which healed after treatment with different antibacterial drugs, but recurred on six different occasions during a period of twenty months after the operation. Staphylococcus aureus or epidermidis was isolated after aerobic incubation while no microbes were detected after anaerobic incubation. The infection appeared to be localized to a suture of polypropylene. The infection regressed and no more fistulas appeared after this suture had been removed.

Animals↗
PubMed1975

[Antibiotic resistance and transferable antibiotic resistance of Escherichia coli isolated from Swedish calves 5 and 30 days old].

E. coli strains isolated from 5-day-old and 30-day-old healthy calves were tested for antibiotic resistance and H-factor mediated antibiotic resistance. An average of 1.6 antibiotic-resistant strains and 1.1 strains with transferable antibiotic resistance were isolated from each of the investigated calves. In comparison with the 30-day-old calves, the 5-day-old calves had significantly more strains with transferable antibiotic resistance (95.8 percent as against 63.4 percent). The R+ strains isolated from the younger calves transferred significantly more en bloc (43.5 percent as against 10.0 percent) and double plus multiple resistance (5292 percent as against 24.4 percent) than did those isolated from the older calves. The most common resistance was to sulphonamide and tetracycline and the most common transferred resistance was to sulphonamide.

Age Factors↗
PubMed1975

[The effect of antibiotic supplementation on antibiotic resistance, transferable antibiotic resistance, morbidity, and growth in calves (author's transl)].

112 calves, divided into four groups, were given milk substitutes containing tetracycline (high-dosage feed), zinc bacitracin or Lactosat (control) and concentratesw with or without zinc bacitracin (Table I). We have investigated the incidence of antibiotic resistance and transferable antibiotic resistance in E. coli strains isolated from the faces of these calves and checked the growth and state of health in the four groups. Growth was also studies in a further ten feeding series comprising a total of 258 calves. Half this number received zinc bacitracin in milk substitute, the other half were fed milk substitute containing Lactosat, instead of antibiotics (Fig. 8). Tetracycline led to a quick increase of antibiotic-resistant straing (Fig. 4--6). This increase is significant in comparison with the other groups. Significant increases of resistance were also noted to ampicillin and chloramphenicol (Fig. 7), althoug these drugs were not used. A significant increase of the transferable resistance was also observed in the group of calves given tetracycline (Fig. 7) and to 65% at about 31/2 months after the end to 38% within 12 days (Fig. 7) and to 65% at about 31/2 months after the end of tetracycline feeding (Fig. 7). A marked increase of en-bloc transfer was also noted after completion of tetracycline feeding (Fig. 2). Up to slaughter, at the age of 6 months, no better growth was obtained with zinc-bacitracin supplement than with milk substitute without antibiotics but containing Lactosat. During the milking period the results varied between the different feeding series. In some series the mean growth in the zinc-bacitracin group was better than, in some no different from, and in other s poorer than that in the Lactosat group (TableII, Fig. 8). The only demonstrable positive effect of tetracycline supplement was a tendency twwards better health during the period of administration of the drug (Table II...

Ampicillin↗
PubMedDate not supplied

Experience of a 10-year use of competitive exclusion treatment as part of the Salmonella control programme in Sweden.

In Sweden, competitive exclusion (CE) treatment has been used since 1981 as a part of the national control programme for Salmonella. According to the programme all broiler flocks are tested for Salmonella before slaughter thus providing an evaluation of CE treatment. The CE culture used is mainly for the two consecutive flocks raised in a unit after a Salmonella-infected flock has been identified. During the period 1981-1990 Ce culture has been given to 179 flocks, involving 3.82 million chickens. Only one of the treated flocks was found to be Salmonella-positive. A special study during a period when Salmonella was spread by contaminated feed demonstrated that CE treatment was effective in controlling Salmonella under field conditions. A likely contributory factor is that the hatcheries in Sweden can be claimed to be Salmonella-free. In addition, the control programme and related action, have led to a very low incidence of Salmonella in broiler chickens. A nationwide study carried out in 1990 demonstrated that less than 1% of broiler chickens was contaminated with Salmonella after slaughter.

Animal Husbandry↗