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Biomedical subjects

M Wiener

Publications and source records attributed to M Wiener.

At least 73 records · Page 4Linked to original sources
PubMed1980

Antibiotic-sensitive Serratia marcescens infections complicating cardiopulmonary operations: contaminated disinfectant as a reservoir.

A cluster of Serratia marcescens infections complicating cardiopulmonary bypass operations was traced to contaminated quaternary ammonium disinfectant. Failure of hospital personnel to clean the disinfectant spray bottles before refilling them had enabled the organisms to survive and contaminate the environment, including the extracorporeal circulator. The organisms grew in two of four formulations of quaternary ammonium disinfectant. Serratia sensitivity to ampicillin and tetracycline was an epidemiological marker of a common-source outbreak.

Anti-Bacterial Agents↗
PubMed1978

Echocardiographic abnormalities in patients with transfusion-dependent anemia and secondary myocardial iron deposition.

The heart was evaluated by echocardiography in 56 patients at risk for myocardial iron deposition. Fifty-four had congenital anemia for which they required repeated transfusions, and two had primary hemochromatosis. The data, plotted according to one of three functions of the body surface area, were compared to values obtained in 105 normal subjects whose age spanned a similar range. Left ventricular wall thickness, transverse dimension and mass, as well as left atrial transverse dimension, were increased in the majority of patients with chronic iron overload despite the infrequent occurrence of cardiac enlargement on routine chest films (32 per cent) or electrocardiographic abnormality (16 per cent). Left ventricular ejection fraction was normal in all but four patients. These four patients died within a six month follow-up period suggesting that deterioration in systolic function is an indicator of poor prognosis. Our findings indicate that echocardiography provides a simple noninvasive means for assessing changes in cardiac structure and function that should prove useful in the serial evaluation of patients who are at risk for the development of myocardial iron deposition.

Adolescent↗
PubMed1978

Control of placental 3 beta-hydroxy-delta 5-steroid dehydrogenase: an apparent endogenous regulator of porgesterone synthesis.

Dilution of tissue fractions from human placenta resulted in an increase in the specific activites of 3 beta-hydroxy-delta 5-steroid dehydrongease and of 20 alpha-hydroxysteroid dehydrogenase. The apparent Ks and V max of 3 beta-hydroxy-delta 5-steroid dehydrogenase were altered. It is postulated that this dilution effect is caused by the presence in the placenta of an endogenous inhibitor of steroid synthesis which may be important in the regulation of steroid output by this organ. A mathematical model of such an inhibitor corresponds well to the experimental results.

20-Hydroxysteroid Dehydrogenases↗
PubMed1978

Control of placental 3 beta-hydroxy-delta 5-steroid dehydrogenase: partial characterization of an endogenous inhibitor and an endogenous activator.

Two substances which affect the activity and kinetic characteristics of 3 beta-hydroxy-delta 5-steroid dehydrogenase (delta 5-3 beta-HSD) have been recovered from homogenates of term human placenta by extraction with organic solvents after ethanol precipitation of protein. One of these substances, an inhibitor of the enzyme, is a non-polar unstable substance, which dialyzes through a cellulose nitrate membrane and which appears to be present in the tissue both in the free state and bound to either the enzyme or the microsomal membrane. It was not possible to produce a delta 5-3 beta-HSD preparation free of the inhibitor. The other substance is an activator, polar and stable with a molecular weight of less then 500, which increases both the apparent Km and the apparent V max of delta 5-3 beta-HSD. It is postulated that both substances play a part in control of placental progesterone synthesis.

3-Hydroxysteroid Dehydrogenases↗
PubMed1977

Spatial behavior of schizophrenic and non-schizophrenic psychiatric patients.

The spatial behavior of schizophrenic and non-schizophrenic psychiatric patients (n equal to 64) was assessed as subjects seated themselves for an interview. The methodology employed was one for which normative data were already available. Results indicated no differences in the seating selections of the patient groups, although the spatial behavior of the patient groups differed from that of normals. The results are interpreted in terms of factors generally associated with patient status rather than uniquely associated with a particular diagnosis.

Female↗