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Biomedical subjects

M Wienbeck

Publications and source records attributed to M Wienbeck.

At least 163 records · Page 9Linked to original sources
PubMed1983

[Alcohol and epithelial regeneration in the rat stomach following experimental lesions].

In man, chronic consumption of alcohol has been incriminated as a promoting factor in the development of columnar-lined lower esophagus (Barrett's syndrome). To test the effects of alcohol on the regeneration of squamous epithelium, rats were fed a diet containing 2,5 g alcohol daily for 6 weeks after the junctional region between the squamous epithelium of their fore stomach and the columnar epithelium of their glandular chamber had been injured and denuded. Compared to animals fed an isocaloric control diet the alcohol-fed rats showed neither major macroscopical nor histological differences in the regeneration process of the epithelium. Under the influence of alcohol the mucosal border did not move in an orad direction. Thus, these results fail to support the hypothesis of alcohol promoting the replacement of defects in squamous epithelium by columnar epithelium which is thought to be the major pathomechanism in Barrett's syndrome.

Alcohol Drinking↗
PubMed1982

Effects of high dose antacids on bowel motility.

The effect of two antacid preparations containing magnesium and aluminum (Riopan, Maaloxan) on stool frequency, stool consistency, stool weight and oro-anal transit time was tested in a randomized, controlled, double-blind study in 10 healthy volunteers. Both antacids increased stool weight and stool frequency, and lowered stool consistency. The oro-anal transit time was not affected. Antacid-induced diarrhea apparently depends more on changes of transmural fluid transport than on changes of intestinal motility. Thus, secretory and osmotic diarrhea can occur without accompanying changes in gastrointestinal motility.

Adult↗
PubMed1982

The effects of leucine-enkephalin on the spontaneous motility of the circular muscle of the cat colon.

Since the effects of endogenously occurring opiates in the regulation of colonic motility are unknown, we set out to study the actions of leucine-enkephalin on the spontaneous contractile and electrical activity of the isolated circular muscle of the cat colon. The muscle strips exhibited regular rhythmic contractions and myoelectrical slow waves 3.67 +/- 0.16 (SEM) times/min. Mean contraction force was 1.20 +/- 0.09 mN. Leucine-enkephalin caused a dose-dependent increase in contractile activity by a factor of 8.24 +/- 2.68; ED50 was 2.23 X 10(-9) M, ED100 4.33 X 10(-8) M. Methionine-enkephalin was equally effective, but morphine was much less effective. Naloxone acted as a specific antagonist. Concentrations of 10(-8) and 10(-7) M shifted the dose-response curve to the right, at the ED50 of leucine-enkephalin by 0.66 and 1.63 log units, respectively. Naloxone exhibited the characteristics of competitive antagonism; pA2 was -8.69, the slope was 1.06. Other antagonists did not affect the enkephalin actions on the muscle. The results of this study suggest that leucine-enkephalin acts on specific receptors of the circular muscle of the cat colon. It is conceivable, therefore, that leucine-enkephalin exerts its effects under physiological conditions to increase segmenting motor activity.

Animals↗
PubMed1982

The effect of pirenzepine on esophageal motility.

The effect of pirenzepine on esophageal motility was studied in ten healthy volunteers by manometry. Pirenzepine reduces lower esophageal sphincter pressure (LESP), amplitude, and duration of esophageal contractions, but it increases velocity of propagation of esophageal contractions. On the other hand, it is known that pirenzepine inhibits gastric acid secretion. Therefore, the reduction of contractile force in the esophagus caused by pirenzepine does not necessarily mean an increased risk of peptic gastroesophageal reflux.

Adult↗
PubMed1982

[A method to transmucosal transport in the human esophagus (author's transl)].

A modified 9-luminal manometric tube served to perfuse the esophagus with 3.2 mmolar hydrochloric acid containing 2% polyethylene glycol (PEG) and to aspirate the esophageal contents. The esophageal secretion was calculated from the PEG dilution in the aspirates. Neutral red injected intravenously reddened selectively gastric juice. Red esophageal aspirates were discarded., In 6 health subjects esophageal secretion was 1.0/+-0.2 ml/min after 1 hour perfusion. It contained 38 /+-11 mmol/l na+, 3.3/+-1.4 mmol/l K+, 27/+-6 mmol/l Cl-, and 50/+-13 mumol/l N-acetylneuraminic acid (NANA). Thus this method allows measurement of the barrier function of the esophageal mucosa.

Barrett Esophagus↗
PubMed1982

[Measurable parameters in the irritable bowel syndrome (author's transl)].

In patients suffering from the irritable bowel syndrome no morphological substrate for this disease can be found; thus quantitation of functional parameters might be desirable. In the colon these patients exhibit myoelectrical waves of increased frequency, e.g. 3 per minute, as well as an exaggerated retropulsion and a prolonged motor response after food intake, indicating an abnormal motility pattern. In the small gut transit is either accelerated, causing diarrhea, or slowed down, causing constipation; in addition, there is an increased retrograde movement of intestinal gas. The pain threshold is decreased in the small and large bowel; inflation of a balloon or insufflation of gas may reproduce the clinical symptoms of the patients. In the terminal ileum there is net fluid secretion instead of net absorption, as normal. Even the esophagus may be affected, since manometry has demonstrated disturbed peristalsis and a reduced pressure of the lower esophageal sphincter. Such quantification of intestinal function is not a substitute for careful clinical work-up. It has however contributed to a better understanding of the underlying functional disturbances in irritable bowel syndrome.

Colonic Diseases, Functional↗
PubMed1982

[The effects of sympathicolysis on interdigestive small bowel motility (author's transl)].

The effect of the alpha-sympathicolytic agent dihydroergotamin-heparin (DHEH) on small bowel motility was examined in a double-blind cross-over study. Intraluminal pressure of the duodenum and jejunum was measured manometrically in 10 healthy volunteers. Sympathicolysis by subcutaneous injection of DHEH increased the number of contractions in the duodenum and jejunum significantly. Under the influence of DHEH, the number of activity fronts of the interdigestive migrating motor complex was higher than in the placebo experiments; however, the difference was not statistically significant. These results may give an explanation for the beneficial effects of this alpha-sympathicolytic agent seen in the prophylaxis and therapy of paralytic ileus.

Adult↗
PubMed1982

Salivary secretion in reflux esophagitis.

It has been speculated that impaired salivary flow and contents contribute to abnormal acid clearance in patients with reflux esophagitis. To test this hypothesis, salivary secretion of volume, bicarbonate, and N-acetylneuraminic acid was measured in patients with reflux esophagitis, in age- and sex-matched controls, and in healthy young volunteers. Resting saliva was collected by permitting the saliva to drip into a flask every 30 s. Parotid saliva was collected by means of a Lashley capsule during stimulation by oral infusion of 1 ml/min of 2% citric acid. Total mixed saliva was collected by a dental sucker during esophageal perfusion with water and 10-mM hydrochloric acid. The volume of resting saliva and its concentration of bicarbonate were similar in the three groups. The concentration and the output of N-acetylneuraminic acid were higher in the young volunteers than in the two other groups. The volume flow and the composition of stimulated parotid saliva were similar in the three groups of subjects. Volume of total mixed saliva and concentration of bicarbonate and N-acetylneuraminic acid during esophageal perfusion with water were higher in patients with reflux esophagitis than in age- and sex-matched controls and were similar to the values found in young healthy volunteers. Acid perfusion increased the secreted volume of total mixed saliva by 150% and the concentration of bicarbonate by 30% in healthy young volunteers, but not in patients with reflux esophagitis and in the healthy age- and sex-matched controls; the concentration of N-acetylneuraminic acid was left unaffected by acid perfusion in all three groups. These findings disprove the hypothesis of impaired salivation in reflux esophagitis. The age-related loss of salivary response to acidic esophageal perfusion might be the reason why reflux esophagitis with peptic lesions affects predominantly elder people.

Adult↗
PubMed1982

Clomethiazol tablets induce ulcers in the esophoagus.

A 55 year old woman developed severe retrosternal pain and odynophagia four hours after taking a tablet of clomethiazol. Endoscopy revealed extensive ulceration of the upper esophagus 19-23 cm from the incisors. Esophageal manometry showed reduced contraction amplitudes in this area. The lesions healed rapidly after the medication was stopped, and the motility disturbances of the esophagus improved. Thus, clomethiazol tablets have to be included in the list of drugs which can damage the esophageal mucosa. This damage is probably due to the acid salt ethanedisulfonate of the clomethiazol tablets. Clomethiazol capsules are preferable since they do not appear to be harmful to the esophagus.

Acute Disease↗
PubMed1982

[Tuberculous stenosis of the duodenum].

A 51-year-old man came to hospital admission one year after the first occurrence of upper abdominal pain, nausea, fever, melaena and discrete symptoms of inflammatory disease, X-ray examination of the chest, colon and ileum were normal. Sonography and computertomographic examination showed a mass in the pancreatic head region. Diagnosis was established by endoscopy and examination of bioptic material, showing ulcerating and stenosing tuberculosis of the duodenum with caseating, tuberculoid granuloma and acid stabile bacilli. Tubercle bacilli of the human type could be demonstrated in bacterial culture. Granuloma of epitheloid cells could also be found in the liver. Drug therapy with tuberculostatic drugs brought about complete healing of the macroscopical lesions within 4 weeks. In patients with stenosing processes of the duodenum tuberculosis should also be taken into account as a rare cause of this condition.

Biopsy↗
PubMed1981

[Is the sonographic diagnosis of hepatic cirrhosis and hepatic metastases reliable (author's transl)].

In a prospective study the reliability of the sonographic diagnosis of hepatic cirrhosis and metastases was investigated in 101 patients. Sonographic diagnoses were checked by laparoscopy. Hepatic cirrhosis was accurately diagnosed in 78% of the cases and hepatic metastases were correctly diagnosed in 92% of cases. The absence of cirrhosis or metastases was correctly recognised in 93% and 98%, respectively. The sonographic diagnosis of liver cirrhosis is based on five criteria: convexity of the ventral surface, caudal margin greater than 45%, rigid contours on palpation diffuse density of the internal structure, and splenomegaly. The most important criterium for the diagnosis of metastases is the presence of circumscribed contour changes. In 32 patients with cirrhosis and in 12 patients with metastases one diagnosis was incorrect. Thus sonography has a high accuracy in the diagnosis of hepatic cirrhosis and metastases.

Diagnosis, Differential↗
PubMed1981

[Cervical dysphagia in scleroedema adultorum Buschke (author's transl)].

Scleroedema adultorum Buschke is characterized by progressive hardening of the skin. In contrast to scleroderma the hardening occurs in the skin of the trunk while extremities remain largely free. Internal organs are said not to be involved in scleroedema adultorum Buschke. The full picture of the persistent form of scleroedema adultorum Buschke was observed in two patients. One patient complained of increasing dysphagia with regurgitation and aspiration. Manometry and X-ray cinematographic investigation showed inappropriate relaxation of the upper oesophageal sphincter. In the other patient who had not previously had swallowed difficulties manometry showed achalasia of the upper oesophageal sphincter. The functional disturbances of the upper oesophagus indicate the possibility of an involvement of internal organs in scleroedema adultorum Buschke. However, proof of an aetiological connection between disturbances of oesophageal motility and skin disease requires systematic investigations in a larger group of patients.

Adult↗
PubMed1981

[Hiatal hernia--reflux disease. Indications for surgery and initial results of a new treatment method].

Indications for the operative treatment of hiatus hernia with reflux oesophagitis are grade III and IV reflux oesophagitis; if the total acid period equals or exceeds 1.3% of the time of the period of time during which the patient was in supine position (pH-examination); if acid clearance lasts 2.86 min or more after a single reflux period; if radioisotopic counts over the sternal region exceed 3.5--4% of those obtained over the stomach area. Since 1977 we performed a new anti-reflux-operation, which we call "Teres-plasty"in 42 patients with axial hiatus hernia. The procedure is a modified gastropexy by using the ligamentum teres. First results seem to prove that this method can avoid reflux without postoperative syndromes as gas bloat syndrome and dysphagia, which are known to occur after fundoplication.

Adult↗