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Biomedical subjects

M Wicklmayr

Publications and source records attributed to M Wicklmayr.

At least 73 records · Page 4Linked to original sources
PubMed1986

[Comparative studies of the metabolism of MCT/LCT and LCT emulsions in diabetics].

In 7 moderately overweight non-insulin dependent diabetics with slightly elevated triglyceride levels, disappearance rates of MCT/LCT- und LCT-emulsions were compared. 5 metabolically healthy volunteers served as control. During a 3-hour lipid infusion, serum triglycerides reached a steady state with both emulsions in the healthy controls, whereas in diabetic patients, steady state triglyceride levels were seen only with MCT/LCT. After the end of the lipid infusion, the longest half life value concerning the decline of triglyceride levels was found with LCT in diabetics, while significantly shorter and quite similar half life values were found with LCT in healthy controls and MCT/LCT in diabetics. The shortest half life for serum triglycerides was expectedly found in healthy controls. According to these data, parenteral nutrition with lipids in states of disturbed glucose and lipid metabolism--if necessary--should preferentially be done with MCT/LCT emulsions.

Diabetes Mellitus, Type 2↗
PubMed1985

Evidence for a substrate regulation of triglyceride lipolysis in human skeletal muscle.

Glycerol release from the human forearm which is generally used as a semiquantitative index of intramuscular lipolysis was studied under different hormonal influence and substrate supply in healthy volunteers and juvenile diabetics using the forearm technique. Acute insulin deficiency in juvenile diabetics failed stimulating the rate of muscular lipolysis since the rates of glycerol release in normals and diabetics were the same. In addition, in normal volunteers high physiological levels of insulin caused by an intraarterial infusion of the hormone exhibited no effect on the glycerol release from deep forearm tissue. Similarly, an intraarterial infusion of metaproterenol did not accelerate muscular glycerol release in normal man. However, in juvenile diabetics in acute insulin deficiency the same dose of the catecholamine increased the rate of muscular glycerol production. Elevated substrate supply during intravenous infusion of glucose or fructose yielded increased uptake of glucose and fructose into the deep forearm tissue and thereby promptly blocked muscular glycerol release in normal volunteers and in juvenile diabetics. These findings suggest that the rate of lipolysis in muscle tissue is not primarily under the control of hormones but rather by substrate supply.

Adult↗
PubMed1984

Substrate balances across skeletal muscle tissue in severe sepsis.

Substrate metabolism of skeletal muscle was studied by the forearm technique in eight patients with severe sepsis. The data were compared to those of 13 patients after elective surgery. In the septic group forearm blood flow was increased, but muscular utilisation of oxygen was diminished. Arterial concentrations of free fatty acids and ketone bodies were low. Thus, both only played a minor role in the supply of skeletal muscle with substrates. From the decreased production of lactate and alanine and the comparable utilisation of glucose we conclude that in the septic patients energy expenditure of skeletal muscle was mainly met by oxidation of glucose. In contrast to reduced lipolysis of adipose tissue intramuscular lipolysis may still be working since muscular production of lactate and glycerol was correlated. These findings suggest a changing pattern of arterial supply of substrates and utilisation of substrates by skeletal muscle during deterioration of clinical condition in the course of sepsis.

Journal Article↗
PubMed1984

[Postoperative insulin resistance of lipolysis and ketogenesis using the glucose clamp technic].

In seven healthy patients we studied the influence of various doses of insulin on the substrate concentration of free fatty acids and ketone bodies on the first day after major abdominal surgery by the glucose clamp technique. Insulin was infused at a rate of 0.2 and 1.0 mU/kg bw.min for ninety minutes and thus insulin concentrations were raised twice and seven times above the basal value. Already the minimal infusion of 0.2 mU insulin/kg.bw.min lead to a significant decrease of free fatty acids and ketone bodies. Our results show that even in postoperative stress the lipolysis of adipose tissue can be reduced by minimal insulin doses.

Abdomen↗
PubMed1983

Substrate balances across the forearm during the early postoperative period.

The substrate metabolism of skeletal muscle has been studied by the forearm technique in 23 patients after abdominal operation. The data were compared to those of 55 healthy volunteers after an overnight fast. While the uptake of glucose into forearm muscle tissue was increased in relation to its elevated arterial concentration, its rate of oxidation was clearly reduced and the muscle extraction of ketone bodies was increased. Simultaneously, the production of lactate was doubled and the output of glycerol and alanine significantly enhanced. From these data one may conclude that 3 hours after abdominal surgery the energy requirements of skeletal muscle tissue are adequately met by the substrates provided that glucose sparing occurs in association with a rising arterial concentration of KB, and that the release of alanine is accelerated in spite of abundant caloric supply.

Journal Article↗
PubMed1983

Dose-dependent effect of bradykinin on muscular blood flow and glucose uptake in man.

Using the forearm technique, the effect of bradykinin on muscular blood flow and glucose uptake in healthy man in the postabsorptive state (n = 8) was studied at different doses of an intra-arterial infusion of bradykinin (2.5-150 ng/min). The blood flow of the forearm was increased dose-dependently from basal 2.8 +/- 0.3 up to 14.7 +/- 2.8 ml/(100 g X min). At lower bradykinin concentrations (2.5-25 ng/min), muscular glucose uptake was raised parallel to the increased blood flow from basal 0.71 +/- 0.30 to 2.93 +/- 0.50 mumol/(100 g X min). However, at higher doses (50-150 ng/min) glucose uptake was decreased again. Thus, the greatest metabolic effect of bradykinin was seen at a calculated bradykinin concentration of approximately 1 X 10(-9)M in the blood.

Bradykinin↗
PubMed1983

The kallikrein-kinin-prostaglandin system: involvement in the control of capillary blood flow and substrate metabolism in skeletal muscle tissue.

In spite of numerous work done in this field it is not clarified so far how the acceleration of the capillary blood flow, of glucose uptake, and of muscle growth occurring during work and after ischemia is controlled in muscle tissue. Since the signal for the induction of these responses stems from inside the cell, tissue factors have been postulated which should be responsible for the enlargement of the capillary net and the improvement of the tissue's insulin sensitivity. The accumulation of new evidences during the last few years points to an involvement of the kallikrein-kinin-prostaglandin system.

Blood Flow Velocity↗
PubMed1980

Insulin-like activity of bradykinin on amino acid balances across the human forearm.

In order to investigate whether bradykinin which has been shown to improve carbohydrate metabolism of skeletal muscle exhibits also insulin-like activity on amino acid metabolism, balances of oxygen and 13 amino acids across the forearm and forearm blood flow were determined in normal subjects during the arterial infusion of insulin (n = 9, 250 mu-units x kg-1 x min-1), bradykinin (n = 7, 0.2 ng x kg-1 x min-1) and papverine (n = 5, 2 microgram x kg-1 x min-1). As expected, the infusion of insulin exhibited significant reduction of the release of glycine, proline, valine, phenylalanine, leucine, threonine and isoleucine. As insulin, bradykinin lessened the release of 9 amino acids: Glycine, serine, ornithin, valine, leucine, isoleucine and tyrosine. On the contrary, papaverine which exhibited almost identical accelerationof forearm blood flow as bradykinin, did not influence the amino acid release from forearm muscle. These findings further support the notion that kinins liberated during muscle work might be involved in the work-induced insulin-like action on carbohydrate- and also on amino acid metabolism.

Adult↗