Biomedical subjects
M Whitefield
Publications and source records attributed to M Whitefield.
Assessment of the skin penetration properties of different vehicles for topically applied hydrocortisone.
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A trial of a new quaternary ammonium/bromine adduct in the treatment of acne.
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A new formulation of 0.1% hydrocortisone cream with vasoconstrictor activity and clinical effectiveness.
A new formulation of hydrocortisone with vasoconstrictor activity has been shown to be effective clinically and was more effective in a 0.1% concentration than 1.0% Hydrocortisone Cream BPC. Its use should obviate the adverse effects of fluorinated steroids.
The treatment of psoriasis with triacetoxyanthracene.
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The treatment of warts.
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The treatment of psoriasis with triacetoxyanthracene.
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Skin penetration of topical formulations of ibuprofen 5%: an in vitro comparative study.
An in vitro isolated human skin technique with known reliable predictive value for in vivo performance was used to compare the skin penetration of the proprietary ibuprofen gel formulation, Ibugel, with five other commercially available topical formulations containing ibuprofen 5%: Ibuspray, Ibumousse, Proflex Cream, Fenbid Gel and Deep Relief Gel. There was a marked difference between some formulations in the percentage of applied ibuprofen penetrating the skin samples, with Ibuspray, Ibugel and Ibumousse showing the most efficient penetration. The percentage of applied ibuprofen penetrating the skin samples from these formulations was significantly greater (p < 0.05) at all sampling intervals when compared with Proflex Cream, Fenbid Gel or Deep Relief Gel. By 48 h, the percentage of applied ibuprofen that had penetrated through the skin samples from Ibuspray, Ibugel and Ibumousse was approximately 2.5 times greater than that from Deep Relief Gel, 3 times greater than that from Proflex Cream and 5 times greater than that from Fenbid Gel. The data demonstrate that, with topically applied preparations, the composition of the vehicle can have a significant impact on the percutaneous penetration of the active medicament. The possible reasons for this are discussed in terms of partition and diffusion phenomena. Different topical presentations of the same drug substance--especially agents like ibuprofen which are intended for subcutaneous action--cannot be assumed to be pharmaceutically and clinically equivalent or indeed interchangeable.