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Biomedical subjects

M White

Publications and source records attributed to M White.

At least 397 records · Page 22Linked to original sources
PubMed1983

Rapid determination of novobiocin susceptibility for the identification of Staphylococcus saprophyticus.

In order to provide a rapid presumptive identification of Staphylococcus saprophyticus, the Autobac MTS was investigated as a method of determining susceptibility to low concentrations of novobiocin. Novobiocin-sensitive strains showed an LSI of greater than or equal to 0.6 and a zone size of greater than or equal to 16 mm on Mueller-Hinton agar; resistant strains showed an LSI of less than or equal to 0.6 and no zone of inhibition.

Microbial Sensitivity Tests↗
PubMed1983

Air within a pancreatic inflammatory mass: not necessarily a sign of abscess.

Intrapancreatic air is considered to be a reliable if not a diagnostic sign of pancreatic abscess. The presence of extraluminal air within the pancreatic bed may also result from perforation of a pseudocyst into adjacent bowel. We describe a patient believed to have a pancreatic phlegmon both clinically and radiographically, in whom intrapancreatic air could be demonstrated on multiple abdominal CT scans over several months. The relatively unremarkable clinical course of this patient during an 11-month interval is incompatible with the usual rapid deterioration and high mortality rate of untreated pancreatic abscess.

Abscess↗
PubMed1983

Anorexia nervosa: a transgenerational system perspective.

In this paper it is suggested that there is a link between the condition of anorexia nervosa and certain rigid and implicit family beliefs. These rigid and implicit beliefs are transmitted from one generation to the next and have a highly constraining effect on all family members. More specifically, these beliefs include role prescriptions that are applied to certain daughters. These daughters are vulnerable to the symptoms of anorexia nervosa. The goal of treatment is to challenge successfully the constraining influence of these beliefs. As such beliefs appear extraordinarily resistant to direct challenge, this is best achieved by rendering the beliefs and their specific consequences explicit to family members. An intervention procedure based on this approach is described and its application to "anorectic families" is demonstrated. The description is supported by transcripts of a family in treatment.

Adolescent↗
PubMed1983

Babesia bovis: isolation of a protective antigen by using monoclonal antibodies.

Three distinct monoclonal antibody-producing hybridomas have been produced against a partly purified protective fraction of Babesia bovis. All three stain the parasite or infected erythrocytes or both in precise and different manners when fluorescent-antibody techniques are used. The relevant antigens for each monoclonal antibody were isolated by immunoadsorption, their native molecular weights being 1.3 X 10(6), 180 X 10(3), and 44 X 10(3). Each antigen reacted in serological assays with homologous and heterologous bovine antisera to B. bovis. Susceptible splenectomized calves were immunized twice, 4 weeks apart, with the respective antigens and were challenged with virulent homologous organisms 2 weeks later. Strong protective immunity was induced by the antigen with a molecular weight of 44 X 10(3), but no significant protection was induced by either of the other two antigens.

Animals↗
PubMed1983

Change in phase relations of circadian rhythms in cell proliferation induced by time-limited feeding in BALB/c X DBA/2F1 mice bearing a transplantable Harding-Passey tumor.

The synchronization of the circadian rhythms of [3H]thymidine uptake (as gauge of DNA synthesis and presumably of cell proliferation) in colon, thymus, and Harding-Passey melanoma were studied in 456 male BALB/c X DBA/2F1 mice under a 12-hr-light, 12-hr-dark regimen. In two groups of animals, the feeding time was restricted to 4 hr/day (either at the beginning of the light span or at the beginning of the dark span). The circadian rhythms in body temperature and [3H]thymidine uptake in the colon were determined in their timing primarily by the time of food intake. In contrast, the circadian rhythm of [3H]thymidine uptake in the thymus and in the transplanted melanoma remained synchronized with the lighting regimen, and under the conditions of this study, was not altered in its timing by the change in feeding time. It thus appears feasible to alter the phase relations between certain circadian rhythms of host and tumor. If applicable to the human situation, this observation might be of interest for the scheduling of chemo- and radiotherapy, in an attempt to obtain maximal effects upon the tumor with minimal undesired side effects upon vital functions of the host.

Animals↗
PubMed1982

Chronic amphetamine: effects on defensive flight in the rat.

Hooded rats were injected with physiological saline or d-amphetamine sulfate for 13 days on a schedule designed to mimic patterns of abuse: one injection on days 1-11, two injections on day 12, and three injections on day 13; amphetamine dosage for the first three injections was 3.5 mg/kg and for all subsequent injections was 5.0 mg/kg. Amphetamine-treated rats (Amphet) showed a dramatic flight reaction in response to a novel stimulus (mechanical robot) that did not elicit flight from saline control animals. Tested on a slow-moving treadmill that carried them toward the stimulus, Amphet rats accumulated only 15% of the trial time at the front of the apparatus nearest the stimulus and accumulated approximately 75% of the trial time at the extreme rear of the apparatus, farthest from the stimulus. Control tests of Amphet rats in the absence of the stimulus ruled out interpretations in terms of motor behavior. In fact, a major advantage of the present procedure is that animals are able to execute the relatively simple defense response despite the occurrence of motor stereotypy. These results suggest that the defense-response paradigm is suitable for the study of chronic amphetamine and may provide a useful adjunctive to existing models of amphetamine psychosis.

Aggression↗
PubMed1982

The effects of smoking on the health and sleep of sportswomen.

This survey studied the health and sleeping patterns of 92 physical education and sports science students highly involved in sport. A strong correlation was found between smoking and various complaints of ill health as well as between smoking and sleep duration and quality of sleep. The results suggest that there is a strong relationship between the constituents of tobacco smoke and poor sleeping habits.

Adolescent↗