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Comparisons of retrospective and current reports of alcoholics and their spouses on drinking behavior.

This study examined the correspondence between reports of alcoholic husbands and their wives on multiple dimensions of alcohol consumption and drinking-related events. Retrospective reports as well as prospective diaries (90 day period) were obtained from both spouses on husbands' behaviors, and correspondence was assessed at group and individual levels. Although there was some variability in agreement between individual husband-wife pairs, overall results indicated that husband-wife correspondence was robust not only for global measures, but also for more specific dimensions of day-to-day consumption. Findings were discussed in terms of issues that affect the validity of alcoholics' reports.

Adult↗

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Effect of time and temperature on inactivation of aminoglycosides by ampicillin at neonatal dosages.

The administration of gentamicin at least 1 hour before administration of ampicillin in neonates has been advocated because of in vitro inactivation of aminoglycosides by beta-lactam antibiotics. This method would cause a delay in ampicillin dosing in the treatment of serious bacterial infections and unnecessarily complicate nursing procedures. We studied the effect of varying concentrations of ampicillin (50, 100, 200, and 400 micrograms/ml) on aminoglycosidic antibiotics in vitro with the use of stock solutions diluted in pooled sera obtained from cord blood and incubated samples at 25 degrees C, 37 degrees C, and 40 degrees C. We found inactivation of aminoglycosides to be dependent on time, temperature, and ampicillin concentration, but the degree of inactivation was small and does not support temporal separation of parenteral administration of ampicillin and aminoglycosides to neonates.

Ampicillin↗