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Biomedical subjects

M Werner

Publications and source records attributed to M Werner.

At least 379 records · Page 21Linked to original sources
PubMed1975

Concepts for the rational selection of assays to be used in monitoring therapeutic drugs.

As the domain of monitoring therapeutic drugs rapidly expands from experimental investigations to everyday patient care, all clinical laboratory scientists, but especially clinical chemists, must learn to deal with their involvement in this expansion. First, the theoretical concepts underlying clinical pharmacology must be appreciated so that the laboratory's participation in it can succeed. Individual differences cause unpredictable variations of response to the customarily standardized drug dosage. Properly used, assays of drugs in blood can eliminate such variabilities. Second, the practical selection of which drug assays a laboratory intends to provide must be based on a rational evaluation of assay usefulness, integrating both clinical and laboratory considerations. Such a decision model is suggested; it is generally applicable in allocating priorities among an ever-increasing number of proposed tests under the constraint of finite resources.

Chemistry, Clinical↗
PubMed1974

Effect of histamine H2-receptor blockade on vagally induced gastric secretion in man.

Metiamide, an antagonist of histamine H(2) receptors, was administered intravenously to normal subjects and to patients with a peptic ulcer during vagal stimulation with a constant infusion of insulin. In normal and peptic-ulcer subjects there were reductions of 70% and 71% respectively in gastric-acid output compared with control tests on the same subjects. The decreased acid output resulted from a reduction in both volume of secretion and acid concentration. Metiamide is therefore a potent inhibitor of vagally-induced gastric acid secretion.

Adult↗
PubMed1974

Eye discomfort when reading microfilm in different enlargers.

At a large banking firm, the lighting conditions under which middle-aged women employees read microfilms in different enlargers were studied. Complaints from the staff were analyzed and compared with the results obtained. Discomfort glare, due to heavy contrasts between the dark documents on the screens and other light surfaces in the visual fields, was the main cause of the complaints. It was recommended that individual near-work spectacles might decrease or eliminate some of the disturbing factors which had led to the subjective complaints. Suggestions were made for improving the enlargers.

Journal Article↗