[On the possibility of occurrence of allergic cross reaction to cerebral antigen in multiple sclerosis].
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Biomedical subjects
Publications and source records attributed to M Wender.
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Modern diagnosis of Schilder's disease is based on elimination by enzymatic test of the metabolic forms of diffuse sclerosis and elimination of subacute sclerosis panencephalitis with EEG investigations and determination of measles antibodies, demonstration by computer tomography of demyelination foci, and demonstration of typical changes in visual and auditory evoked potentials. Correct diagnosis of Schilder's disease opens the possibility of tentatives of treatment with immunosuppression, plasmapheresis and lymphocytopheresis.
A case-control study was carried out comparing 300 patients with multiple sclerosis with 300 patients with ischialgia of various aetiology matched for age analysing history data concerning past infectious diseases and their complications in childhood. The following conclusions have been reached: In patients with multiple sclerosis exanthematous diseases (measles, rubella, varicella) and mumps in childhood were more frequent than in controls. No history of measles in late childhood occurring with higher frequency was found in the multiple sclerosis group as compared with controls. The age of measles had no greater pathogenetic importance for the development of multiple sclerosis. A high susceptibility to viral infections in childhood contributes to the susceptibility to neuroallergic reactions such as multiple sclerosis at later age.
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