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Biomedical subjects

M Welsh

Publications and source records attributed to M Welsh.

130 records · Page 8Linked to original sources
PubMedDate not supplied

Reproductive risks in a community-based distribution program of oral contraceptives, Matamoros, Mexico.

A Reproductive Risk Factors Survey was carried out in 1982 in conjunction with a community-based distribution (CBD) program in Matamoros, Mexico, to determine whether the distribution of oral contraceptives to women through CBD programs exposes any demonstrable group of users to more health risks than if the program had not been put in place. The methodology involved interviews by nurses of program pill users and non-program pill users. Health indicators related to cardiovascular accidents were the main focus of comparison between the groups. The data indicate that respondents were well informed about their own health status, and, in terms of the conditions studied, program users were found to be similar in health status to non-program pill users whether or not they were ever examined for contraindications to pill use. The study indicates that this CBD program has not increased the risks associated with pill use for its clients and has, in fact, given protection from pregnancy to women who may otherwise not have had access to oral contraceptives.

Adult↗
PubMedDate not supplied

Expression of certain antiproliferative and growth-related genes in isolated mouse pancreatic islets: analysis by polymerase chain reaction.

With the aim at understanding the mechanism responsible for the low proliferative capacity of the adult pancreatic B-cell, expression of the "antiproliferative" gene retinoblastoma and that coding for p53 as well as certain genes coding for cyclin B1, cyclin D1 and p34cdc2 and p33cdk2 kinases, all of which are important for the cell cycle and mitosis, was assessed by the polymerase chain reaction in a semiquantitative assay. Islet expression of the p53 and retinoblastoma genes was higher than that of the liver, but lower or the same as that of the spleen, making expression of these genes an unlikely explanation for the low replicatory capacity of the B-cell. Similarly, islet expression of the genes coding for p33cdk2 kinase and cyclin D1 was not very different from that of the spleen. The levels of cyclin B1 mRNA and the mRNA coding for the p34cdc2 kinase were however both low in islets, compared with those of the spleen and the insulin-producing RINm5F cell line. Stimulation of B-cell proliferation did not change the expression of any of the genes studied. It is concluded that the low expression of cyclin B1 and p34cdc2 kinase and failure to induce these by stimulation of B-cell replication may play a role in maintaining adult B-cells in a state of low proliferative capacity.

Animals↗