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Biomedical subjects

M Wells

Publications and source records attributed to M Wells.

At least 217 records · Page 12Linked to original sources
PubMed1977

Otolaryngological disturbances in Waldenstrom's macroglobulinaemia.

Four cases of Waldenstrom's macroglobulinaemia (WM) are described in which otoloaryngeal symptoms were present. Symptoms in WM are related to (a) bleeding diathesis and (b) hyperviscosity of the blood. The bleeding diathesis was manifested as epistaxis in 2 cases. In one case which came to postmortem, histological examination of the temporal bone showed complete disruption of the labyrinth by haemorrhage. Hyperviscosity probably was the source of hearing loss which took place in all 4 patients and had the following characteristics: (a) sudden onset (b) cochlear type (c) bilateral (d) sequential involvement of the two sides (e) improvement on treatment of the disease with alkylating agents or plasmapheresis. Early diagnosis of WM is thus important.

Aged↗
PubMed1976

A subcortical approach to swallow pattern therapy.

The neuromuscular facilitation technique was experimentally used with tongue-thrust patients in order to examine the results of application of this technique to such a population. Four boys and seven girls with a mean age of 116 months were referred by orthodontists in the greater Detroit area to Children's Hospital of Michigan. Each had previously been diagnosed as manifesting tongue thrust. Brushing, icing, and pressure were applied in a home training program for 6 months. Serial dental models were made at 0,3,6 and 12 months, the latter being used to detect regression 6 months after termination of the therapy regimen. Results are presented to support the contention that neuromuscular facilitation is a useful technique in swallow pattern therapy. Ancillary findings are presented which support the contention that mouth breathing and thumb and finger-sucking precede the onset of tongue thrust.

Adolescent↗
PubMed1975

Essential fatty acid deficiency in human adults during total parenteral nutrition.

Three patients undergoing prolonged total parenteral nutrition at home developed skin lesions, characterized by dryness and scaly appearance, initially confined to the folds but becoming subsequently generalized. Fatty acid measurements in plasma of these patients showed a markedly abnormal lipid pattern: accumulation of 5,8,11-eicosatrienoic acid (20:3omega9) and a high 20:3omega9-to-20:4omega6 ratio. When parenteral fat (Intralipid) was administered, 500 ml/day, serial measurements of fatty acids showed a progressive normalization of the abnormal pattern and a dramatic improvement in the skin lesions. It appears that the daily requirement for linoleic acid in the adult, particularly during the period of rapid anabolism, has not been clearly established. Because more and more patients are becoming partly or totally dependent on parenteral nutrition for prolonged periods of time, the availability of parenteral fat preparations is urgently needed.

Adolescent↗