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Biomedical subjects

M Weinstein

Publications and source records attributed to M Weinstein.

208 records · Page 12Linked to original sources
PubMedDate not supplied

Giant fusiform aneurysm of the cerebral arteries.

Giant fusiform aneurysm of the cerebral arteries was found in 11 patients during a 20-year period. The 7 males and 4 females ranged in age from 9 to 68 years (mean: 49 years). The supraclinoid segment of the internal carotid artery (ICA) and the M-1 segment of the middle cerebral artery (MCA) were the most frequently involved arteries. Multiple aneurysms were identified in 3 patients. Compression of adjacent intracranial structures was the usual cause of symptoms, and only 2 patients experienced subarachnoid hemorrhage. One patient presented with transient ischemic attacks. Computed tomography, with and without Hypaque infusion, clearly demonstrated the aneurysms in the 6 of 7 patients studied. Thrombus was invariably seen in the lumen of the aneurysm. Cerebral angiography in 11 patients displayed marked dilatation and elongation of the involved artery. The dilatation frequently extended into connecting arteries. Surgical treatment was carried out in 6 patients, including 2 with aneurysm entrapment and decompression, 2 with proximal ICA ligation, 1 with wrapping and 1 with wrapping and superficial temporal artery (STA) to MCA anastomosis. Death occurred in 2 patients not treated surgically.

Adolescent↗
PubMedDate not supplied

Focal parenchymal lesions in transient ischemic attacks: correlation of computed tomography and magnetic resonance imaging.

Twenty-two patients with the clinical diagnosis of transient ischemic attacks were prospectively evaluated by computed tomography (CT) and proton magnetic resonance imaging (MRI). Nineteen patients also underwent cerebral angiography. The MRI studies were performed with a prototype super-conductive magnet using a 0.6 Tesla or a 1.5 Tesla magnetic field. Two pulse sequence techniques were used resulting in T1 and T2 weighted images. All studies were interpreted descriptively by a single neuroradiologist in a blinded fashion, with special attention to focal parenchymal abnormalities. Patients with previously documented clinical strokes or reversible ischemic neurologic deficits lasting more than 24 hours were excluded. The CT scans revealed focal areas of abnormalities in 7 of 22 patients (32%), while the MRI scans showed focal changes in 17 patients (77%). All the CT lesions were clearly visualized on MRI. The MRI changes were better seen on T2 weighted images as areas of increased signal intensity. There was a marked preponderance of deep hemispheric lesions on both CT and MRI studies. Focal parenchymal abnormalities were not limited to the symptomatic vascular territory. We conclude that MRI reveals focal parenchymal changes in the majority of patients with transient ischemic attacks and is more sensitive than late generation CT scans. However, specificity appears to be poor, and may limit clinical usefulness. While the significance of the MRI "lesions" remains speculative, they may represent markers of chronic cerebrovascular disease in these patients.

Adult↗
PubMedDate not supplied

Semiconductor probe measurements in beagle pups during deciduous tooth development.

Bone-seeking radiopharmaceuticals were used together with clinical and radiographic procedures to study tooth development in dogs. Similarities in the pattern and time course of radiopharmaceutical uptake in jaw areas studied suggest that changes in alveolar bone metabolism are not closely related to eruption times of individual teeth.

Age Factors↗
PubMedDate not supplied

Sector computerized tomography of temporal bone and base of skull.

The field of computerized tomography (CT) scanning has been one of the great medical advances of the 20th century. The field is developing rapidly with new hardware and software becoming available on a monthly basis. At the Cleveland Clinic Foundation, patients have been studied by using a sector computerized tomography scanner that has the capability of not only improved spatial resolution but also software programs, with the ability to reconstruct data using different algorithms. This versatility in reconstructing the raw data has resulted in a remarkable improvement in the ability to study the temporal bone and the base of the skull. This paper will present technical data in reference to this new generation of scanner and also show examples of the type data that are becoming available to the otolaryngologist studying lesions of the base skull and temporal bone.

Cranial Fossa, Posterior↗
PubMedDate not supplied

Quantification of temporal lobe resections: a new approach.

Extent of resection in temporal lobectomy has been traditionally based on intraoperative linear measurements. The complex geometrical contour of the temporal lobe limits the precision and accuracy of such measurements, and it is often difficult to verify the extent of actual resection after surgery. The authors propose a new method of evaluating extent of resection based on a 20-compartment model of the temporal lobe. The temporal lobe is divided into five anteroposterior coronal sections in relation to the anterior and posterior borders of the mesencephalon. Each section is then divided into superior lateral, inferior lateral, basal, and medial quadrants. The resulting compartments are easily identified on postoperative magnetic resonance images obtained along the coronal plane. Resection within each compartment is noted as none (0), partial (1), or complete (2). An index of resection can then be computed for superior lateral, inferior lateral, basal, and medial quadrants and for the whole temporal lobe. Potentially, this technique can be used to evaluate surgical failures and correlate extent of resection with surgical outcome and neurologic complications. It also allows objective and semiquantitative comparison of surgical approaches practiced at different institutions.

Anthropometry↗
PubMedDate not supplied

The Bethesda System. Impact on reporting cervicovaginal specimens and reproducibility of criteria for assessing endocervical sampling.

This study examined the impact of applying the Bethesda System guidelines for specimen adequacy on cytopathologic diagnosis at the Johns Hopkins Hospital laboratory of cytopathology during a one-year period. Application of the Bethesda guidelines resulted in a 1.3% unsatisfactory rate. In addition, 3.8% of specimens were satisfactory but contained an inadequate endocervical component (IEC). Smears obtained after a cone biopsy or an initial IEC smear were IEC in 16.5% and 18.7% of cases, respectively. The IEC rate following an initial smear lacking an endocervical component was 11.8% in repeat specimens obtained with an endocervical brush as compared to 29.4% in those obtained with a spatula alone. The reproducibility of the Bethesda criteria for assessing endocervical sampling was evaluated by comparing the level of agreement between three independent reviewers examining 40 test cases. Three-way agreement was achieved in 75% of cases. Two-way agreement ranged from 80.0% to 87.5%. We conclude that implementation of the Bethesda System guidelines for assessing specimen adequacy should produce a minimal impact on cytopathologic reporting and gynecologic practice. Repeat specimens lacking an endocervical component may be encountered relatively frequently in certain subsets of patients.

Adult↗