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Biomedical subjects

M Weingarten

Publications and source records attributed to M Weingarten.

At least 19 recordsLinked to original sources
PubMed1990

Identification of sorbitol 3-phosphate and fructose 3-phosphate in normal and diabetic human erythrocytes.

Using 31P NMR spectroscopy, we have identified sorbitol 3-phosphate and fructose 3-phosphate in normal human erythrocytes wherein their concentrations are estimated to be 13 mumol/liter cells. Incubation of hemolysates with sorbitol, fructose and ATP suggest that both sorbitol and fructose are phosphorylated separately and directly at the 3-hydroxyl position suggesting the presence in these cells of a novel and specific kinase(s). In addition to sorbitol 3-phosphate and fructose 3-phosphate which were previously identified in the mammalian lens and sciatic nerve, erythrocytes have two extra metabolites resonating at 6.7 and 6.8 ppm in the 31P NMR spectrum. Although not identified in this study, the unusual chemical shifts of these compounds, their low pKa values and the fact that they appear as doublet in proton-coupled 31P NMR spectra, suggest that these phosphomonoesters belong to the same class of metabolites as sorbitol 3-phosphate and fructose 3-phosphate. Preliminary studies of erythrocytes from an unselected group of diabetic subjects showed an overall increase in the concentration of all four metabolites, although an overlap with normal values was noted.

Adult↗
PubMed1990

Respiratory monitoring of carbon dioxide and oxygen: a ten-year perspective.

During the past 10 years, instrumentation has been developed that can continuously and noninvasively measure changes in carbon dioxide and oxygen. The information generated, which cannot be obtained through the human senses, provides vital clinical data regarding the effectiveness of intubation, ventilation, circulation, oxygenation, and the circuit. This instrumentation plays a major role in decision making both in the safe conduct of anesthesia and mechanical ventilation as well as in the detection and prevention of potentially catastrophic mishaps. For these reasons, a review of what has been learned regarding the instrumentation, collection, and interpretation of the clinical data, and the clinical value of the information is timely. The clinical significance of the carbon dioxide and oxygen waveforms, inspired to expired carbon dioxide and oxygen differences, alveolar-arterial gradients, and global supply-to-demand oxygen relationships measured by capnography, oxygraphy, and pulse oximetry are addressed in this essay.

Anesthesia, Closed-Circuit↗
PubMed1989

[Blood pressure of Yemenites in Israel similar to that of other Israelis].

Studies of Yemenite immigrants shortly after their arrival in Israel reported markedly low blood pressures. A community survey was conducted in the town with the most Yemenite immigrants, 40 years after their immigration. Blood pressures were measured by family practice physicians in the course of their routine clinical work. The averages of 3432 measurements recorded in 4955 adults were the same as those reported in studies of other Israeli populations for all age groups, except in women over the age of 60, in whom it was low. Pressures rose with age from 20 to 65 years, falling off slightly in the oldest age groups. The distribution curve was positively skewed, with a tail of higher values. Hypertension was diagnosed in 153, and elevated blood pressure, not confirmed as hypertension, was recorded in an additional 226. Except in older women, the clinical epidemiology of blood pressure in Yemenites in Israel is indistinguishable today from that of the general population.

Adult↗
PubMed1989

[Duck plague: clinical aspects, diagnosis, control].

A predominantly acute, highly contagious disease of the waterfowl is called duck plague or virus enteritis of ducks. The pathogenic agent is a herpes virus, type A. The clinical course of the disease and its pathological-anatomical findings are described and the possibility of prophylactic immunization is discussed. The results of lab trials demonstrate the effectiveness of a vaccine against the duck plague.

Animals↗
PubMed1987

Fetal gastric pseudomasses.

Discrete echogenic areas of 4-12 mm were observed in the fetal stomach on seven prenatal sonograms. The finding was incidental and solitary during the second trimester in six normal pregnancies. It was noted during the third trimester in a case of meconium peritonitis. These echogenic areas displayed a homogeneous texture. They disappeared on repeat prenatal examination in six patients who did not reveal any gastrointestinal symptoms on postnatal follow-up. Although their origin is not certain, these fetal gastric pseudomasses should be interpreted cautiously.

Diagnostic Errors↗
PubMed1986

Bifid blind-ending ureters.

There have been scattered cases of bifid blind-ending ureters reported in the literature. We report 2 cases of unilateral bifid blind-ending ureter, 1 of which was in a bilateral complete duplex system.

Adult↗
PubMed1974

Microtubules from mammalian brain: some properties of their depolymerization products and a proposed mechanism of assembly and disassembly.

Depolymerization products of purified microtubules from porcine brain were examined by sedimentation analysis and electron microscopy. The complete depolymerization mixture exhibited 36S and 6S components in concentration-dependent equilibrium, whether depolymerization was caused by low temperature or by calcium ion. These components were recognized by electron microscopy as spirals and rings, and small particles. Agarose column chromatography yielded two major fractions, a leading one comprising mostly 36S and some 6S material and a trailing one of solely 6S material. The latter had high specific colchicine-binding activity and no tendency to polymerize. For the leading peak material these properties were the converse. It is proposed that tubulin molecules (of mass 110,000 daltons) exist in two states, here called X and Y, with those of the X-state equivalent to the material found predominantly in the trailing fraction, and those of the Y-state equated with the material in the leading fraction. Participation of tubulin molecules in microtubule assembly and disassembly is discussed, based on the assumption that those of both states have longitudinal and lateral binding domains whose strengths differentially depend upon temperature and calcium-ion concentration.

Animals↗