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Biomedical subjects

M Weil

Publications and source records attributed to M Weil.

At least 253 records · Page 14Linked to original sources
PubMedDate not supplied

[Intra-arterial chemotherapy for hepatic metastases. Experience of the Pitié-Salpêtrière Hospital Group].

Intra-arterial chemotherapy of hepatic metastases is theoretically interesting because of the essentially arterial blood supply of these metastases in contrast with the healthy tissue and because of the theoretical pharmacokinetic advantage for certain drugs, depending on their quotient of hepatic extraction and the wole body clearance. We have treated 43 patients with this technique. The primary cancer was a cancer of the colon in 10 patients, a breast cancer in 16 patients, a melanoma in 7 patients and cancers of other sites in 10 patients. The chemotherapy was initially administered by selective catheterisation of the hepatic artery via an axillary approach and usually consisted of a bolus injection of adriamycin 40 mg/m2 and mitomycin 10 mg/m2 and an infusion of 5 FU 1 g/m2 for 24 to 72 hours. In 15 patients, we surgically implanted a subcutaneous reservoir and catheter. To date, we have performed 114 arterial injections via the catheter and 60 injections into sub-cutaneous reservoirs. We have observed few complications, apart from thrombosis of the axillary artery (3 cases) and of the hepatic artery (5 cases). We have obtained 4 complete responses, 16 partial responses, 8 stabilisations, 10 failures and, unfortunately, 5 patients died rapidly after a single course of chemotherapy and could not be evaluated. The response rate was particularly high for the breast cancers (about 60 percent) and the cancers of the colon (more than 50 percent). We have also observed 3 complete responses in patients treated by intravenous chemotherapy with the same protocol.

Adult↗
PubMedDate not supplied

[Stage III and VI Hodgkin's disease. Success and failure of therapeutic protocol H2 65 (author's transl)].

224 patients with stage III and IV Hodgkin's disease (H.D.) have been treated by 6 monthly MOPP courses. 190 patients achieved remission and among them there were 109 complete remissions (C.R.) . All patients received vinblastin maintenance combined with "reinduction" courses of MOPP (68 patients) or irradiation (57 patients). At ten years, remission curves are "on plateau" at 72% for those patients who achieved C.R. at 48% for those who had partial remission, and for all patients the ten years survival rate is 53%. The parameters which influence C.R. achievement are age, fever, histology, but the best predictive parameter seems to be lymphogram: diffuse involvement and aspects of cystic storage pattern as seen in "non Hodgkin lymphoma" heralding an unfavorable prognosis. The lymphogram picture should thus be included as parameter of initial classification and treatment active in "non Hodgkin lymphoma" such as Vincristine - Cytoxan - Prednisone - Adriamicin should be tried in these high risk patients.

Antineoplastic Agents↗