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Biomedical subjects

M Webber

Publications and source records attributed to M Webber.

23 records · Page 2Linked to original sources
PubMedDate not supplied

Quinolone resistance in Escherichia coli.

Escherichia coli is an important pathogen of animals and humans that causes great financial cost in food production by causing disease in food animals. The quinolones are a class of synthetic antimicrobial agents with excellent activity against Escherichia coli and other Gram-negative bacteria used in human and veterinary medicine. Different quinolones are used to treat various conditions in animals in different parts of the world. All members of this class of drug have the same mode of action: inhibition of topoisomerase enzymes, DNA Gyrase and Topoisomerase IV. Escherichia coli can become resistant to quinolones by altering the target enzymes, reducing permeability of the cell to inhibit their entry, or by actively pumping the drug out of the cell. All these resistance mechanisms can play a role in high-level fluoroquinolone resistance, however target site mutations appear to be most important. As all quinolones act in the same way resistance to one member of the class will also confer decreased susceptibility to all members of the family. Quinolone resistant Escherichia coli in animals have increased in numbers after quinolone introduction in a number of different case studies. The resistance mechanisms in these isolates are the same as those in resistant strains found in humans. Care needs to be taken to ensure that quinolones are used sparingly and appropriately as highly resistant strains of Escherichia coli can be selected and may pass into the food chain. As these drugs are of major therapeutic importance in human medicine, this is a public health concern. More information as to the numbers of quinolone resistant Escherichia coli and the relationship between resistance and quinolone use is needed to allow us to make better informed decisions about when and when not to use quinolones in the treatment of animals.

Animals↗
PubMedDate not supplied

Patient teaching strategies for peripheral laser procedures.

The focus of this article is the development of an individualized teaching strategy for laser angioplasty patients. After a presentation of a typical laser angioplasty case history and description of the procedure, the problem of individualizing a new patient teaching program is discussed. Consideration is given to previous education, prior experience, patient expectations, coping skills and willingness to learn. The problem of an effective presentation style is delineated through three specific modalities. Procurement, organization and presentation of new teaching material is integral to a comprehensive patient teaching program.

Aged↗
PubMedDate not supplied

The internal review process: implications for the novice clinical researcher.

The purpose of this article, directed at first-time clinical researchers, is to describe the internal review board process of one clinical research facility and to provide an example of its protocols for conducting clinical research. After a brief history depicting the need for Internal Review Boards, the review process itself, is discussed. Emphasis is placed on the patient's medical/legal rights and safety. Equipped with an understanding of why the review process is necessary and with examples of the review board criteria, the nurse researcher has the tools to begin the research project.

Clinical Nursing Research↗