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Biomedical subjects

M Watson

Publications and source records attributed to M Watson.

At least 271 records · Page 15Linked to original sources
PubMed1976

A rapid and sensitive method for gas chromatographic analysis of the selective piscicide, "Squaxon".

"Squaxon" (1,1'methylenedi- 2 napthol; bis (2 hydroxy-1- naphthyl) methane) was discovered by MacPhee and Ruelle (1968, 1969) to exhibit piscicidal properties that are highly species specific. The chemical is lethal to the Northern (Ptychocheilus oregonensis) and the Umpqua (P. umpquae) squawfish, freshwater cyprinids common to the Pacific Northwest, at water treatment concentrations of less than 100 parts per billion (ppb). Other species of fish, including the more desirable salmonids with which the squawfish competes ecologically, are unaffected until this dosage has been increased severalfold. Because squawfish are widely regarded as undesirable for food or sporting purposes, and because competition from squawfish has severely depleted salmonid populations in some areas (Thompson, 1959; Jeppson and Platts, 1959) the potential use of squaxon for fisheries improvement is quite obvious. Squaxon is currently being tested for this purpose on an experimental basis in selected areas in Idaho, Oregon, and Washington, pending federal clearance for more widespread application.

Animals↗
PubMed1976

The suppressing effect of indomethacin on articular cartilage.

Indomethacin in pharmacological doses was given to rabbits with papain-induced degenerative arthrosis of the knee. The cartilage lesions healed between the 35th and the 70th day of the experiment. The healing was unaffected by indomethacin. However, autoradiographs showed a significantly reduced 35SO4 uptake in the articular cartilage of the animals receiving the indomethacin in both arthritic and control knees.

Animals↗
PubMed1975

Microfractures in the head of the femur.

Microfractures of the trabeculae were studied in the femoral heads of three different population groups. The femoral heads were sliced and then examined with a dissecting microscope. Microfractures were found in large numbers in specimens from British patients who had suffered femoral-neck fracture, and in smaller numbers in femoral heads -aken routine autopsy in India and in China (Hong Kong). There were many more microfractures in the thinner, lightly stressed trabeculae than in the thicker weight-bearing trabeculae in the fractured femoral-neck specimens. The significance of these findings is discussed in the light of current concepts regarding the pathogenesis and significance of trabecular microfractures.

Aged↗
PubMed1975

Therapeutic effectiveness of paracetamol in rheumatoid arthritis.

A single-blind, non-crossover study of the effectiveness of paracetamol, compared with aspirin and indomethacin has been carried out in 143 patients suffering from rheumatoid arthritis. Subjective indices have been employed, and the validity of the present method is discussed. The results of the trial have also been compared with those of a previous study (of prednisone, aspirin and placebo). Paracetamol was not significantly different from placebo, either in terms of pain relief or patient satisfaction rating. Prednisone and indomethacin were significantly better than paracetamol in respect to both parameters, but aspirin was not. On the basis of these results, the frequent prescription of paracetamol as the main therapeutic agent in the treatment of rheumatoid arthritis is not justified.

Acetaminophen↗