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Biomedical subjects

M Wang

Publications and source records attributed to M Wang.

At least 1,045 records · Page 58Linked to original sources
PubMed1984

EEG spectra following phenytoin infusion in seizure patients.

Diphenylhydantoin (DPH) kinetics were studied in five male patients with poorly controlled seizures. EEG recordings were taken on four of the patients immediately prior to and 30 minutes following a 60 minute i.v. infusion of phenytoin sodium. Mean phenytoin levels following post-infusion EEG recordings were 17.1 mg/L. Spectral analysis revealed that phenytoin produced a decrease in the variance of EEG spectral power as a function of time in frequencies between 8-18 Hz. This decrease in the variance of the time series of EEG spectra suggests increased EEG stability and may represent an electrographic marker of the anticonvulsant action of phenytoin.

Adult↗
PubMed1984

Intrageneric and intergeneric transfer of Branhamella catarrhalis beta-lactamase production.

Intrageneric and intergeneric conjugational transfer of beta-lactamase production to a Branhamella catarrhalis recipient is described. The branhamella donor strains were fresh isolates subcultured onto penicillin-containing media directly from the primary plates. A beta-lactamase positive Moraxella nonliquefaciens served as donor in the intergeneric matings. The substrate profiles of the branhamella and moraxella enzymes were indistinguishable as determined by biological assays. Excessive endonuclease activity did not permit a conclusive characterization of isolated extrachromosomal DNA from the branhamella donors.

DNA, Bacterial↗
PubMed1983

Corticotropin releasing factor produces increases in brain excitability and convulsive seizures in rats.

Corticotropin releasing factor (CRF) is a 41-residue peptide, capable of stimulating the secretion of corticotropin (ACTH)-like and beta-endorphin-like immunoreactivity from the adenohypophysis. Low doses of CRF (0.0015-0.15 nM) given intracerebroventricularly (i.c.v.) produced changes in electrographic activity suggestive of increased arousal. Higher doses of CRF (1.5-3.75 nM) induced, over a period of 3-7 h, electrographic and behavioral signs of seizure activity indistinguishable from those which occur following electrical 'kindling' of the amygdala.

Animals↗
PubMed1983

The results of radiation therapy in advanced carcinoma of the lung in the Beijing region of China.

From 1958 to 1973, 682 patients with lung cancer were treated by radiation therapy in the Cancer Institute, Chinese Academy of Medical Sciences, Beijing, China. The clinical presentation, sex, age, histology and stage and palliative effects of radiation therapy were reported. The 1-, 3- and 5-year survival rates were 40.62, 8.94 and 3.81%, respectively. The prognostic factors such as staging, histology, combination with chemotherapy and response of tumours are discussed. The causes of failure are also analysed. It is suggested that improving the local control rate of squamous cell carcinoma would increase the survival rate.

Adenocarcinoma↗
PubMed1983

Multiple acyl-Co A dehydrogenation deficiency (MADD) in a boy with nonketotic hypoglycemia, hepatomegaly, muscle hypotonia and cardiomyopathy. Detection of N-isovalerylglutamic acid and its monoamide.

A boy, aged 7 months, of consanguineous parents presented with an acute onset of vomiting, fever, nonketotic hypoglycemia and acidosis and died from cardiac arrest after ventricular fibrillation. He had hepatomegaly and echocardiographically a non-obstructive cardiomyopathy. Autopsy was not allowed. After birth the child had suffered from a severe respiratory distress syndrome, transient metabolic acidosis and had a sweaty feet odour. Later on, development was retarded with a severe muscular hypotonia. Post mortem, numerous unusual organic acids were found in high concentrations in urine, e.g. dicarbonic acids, 2-hydroxyisobutyric, isovaleric, 3-hydroxyisovaleric acid, N-acyl glycines, isovalerylglutamic acid and sarcosine. This pattern indicated deficiencies of several acyl-Co A dehydrogenases in the metabolism of leucine, isoleucine, valine, lysine, short-chain fatty acids and sarcosine. This could be confirmed using cultured skin fibroblasts which were shown to degrade the corresponding labeled substrates insufficiently to 14CO2. It is assumed that the functional multiple acyl-Co A dehydrogenation deficiency is caused by a deficiency of a common link in the electron transfer system of these dehydrogenases which is inherited autosomal recessively in this family. Among the 12 patients reported, 7 died within the first 5 days of age.

Cardiomyopathies↗
PubMed1982

Atypical phenylketonuria with defective biopterin metabolism. Monotherapy with tetrahydrobiopterin or sepiapterin, screening and study of biosynthesis in man.

Administration of a single dose of tetrahydrobiopterin dihydrochloride, 10--20 mg/kg orally, to a patient with dihydrobiopterin deficiency led to disappearance of clinical symptoms for 4 days, normalization of urinary phenylalanine and serotonin and decrease of elevated neopterin for 2--3 days. A dose-dependent stimulation of serotonin production was observed. A similar effect was noted with even lower doses of L-sepiapterin. The patient is now under monotherapy with tetrahydrobiopterin . 2 HCl, 2.5 mg/kg daily. Other patients with this disease may not respond as well. Results of screening for tetrahydrobiopterin deficiency in 228 cases with hyperphenylalaninemia, including 140 newborns, are reported. There is evidence that biopterin biosynthesis in human kidney and liver proceeds via a dioxo compound and L-sepiapterin.

Biopterins↗
PubMed1982

Atypical phenylketonuria due to biopterin deficiency. Early treatment with tetrahydrobiopterin and neurotransmitter precursors, trials of monotherapy.

This report presents the first case where an infant with tetrahydrobiopterin deficiency has been identified by screening of newborns with hyperphenylalaninemia for tetrahydrobiopterin deficiency. Therapy with L-Dopa, 5-hydroxytryptophan, Carbidopa and tetrahydrobiopterin was started at the age of seven weeks while the child received a normal diet. At that time already muscular hypotonia was observed. The girl, now 2 1/2 years old, shows slight muscular hypotonia and hypomotility, short periods of hypertonic extension of the limbs, and retardation of sensomotor and mental development of about 6-8 months. Monotherapy with tetrahydrobiopterin dihydrochloride, 20-40 mg/kg b.w., diminished the muscular hypotonia. The effect lasted however for only about 1 day. While urinary serotonin and phenylalanine remained normal for at least 3 days and neopterin was only slightly elevated, urinary free dopamine however remained low. Similar results were obtained after 1',2'-diacetyl tetrahydrobiopterin dihydrochloride administration, 20 mg/kg b.w.

5-Hydroxytryptophan↗