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Biomedical subjects

M Walsh

Publications and source records attributed to M Walsh.

At least 271 records · Page 15Linked to original sources
PubMed1987

In vitro evaluation of CP-62,993, erythromycin, clindamycin, and tetracycline against Chlamydia trachomatis.

The antimicrobial activity of CP-62,993 against four Chlamydia trachomatis isolates was compared with those of erythromycin, clindamycin, and tetracycline. The MIC of CP-62,993 was 0.26 to 1.02 micrograms/ml for 100% inclusion inhibition and 0.031 to 0.063 microgram/ml for 50% inclusion inhibition. With pharmacokinetic and antimicrobial studies demonstrating prolonged half-life and in vitro effectiveness, CP-62,993 may make possible a single, short-course treatment regimen for C. trachomatis infection.

Anti-Bacterial Agents↗
PubMed1987

The rorschach assessment of borderline defenses: a concurrent validity study.

This study assesses the concurrent validity of two Rorschach defense scales designed to identify borderline defensive structure. A Rorschach scale designed by Cooper and his colleagues was systematically compared to a defense scale constructed by Lerner and Lerner. Despite considerable overlap on a conceptual and operational level, the scales are based on divergent theoretical models (developmental arrest and fixation) and Rorschach units of analysis (all responses and human responses). Our results are based on the capacity of each scale to discriminate between independently diagnosed samples (neurotic, outpatient borderline, inpatient borderline, schizophrenic) and the relative discriminatory power of particular defenses within each scale to differentiate between groups.

Adolescent↗
PubMed1987

Evaluating borderline students.

While it was difficult for our faculty to face the disparity which arose in deciding whether or not to pass Anne, many important points were raised which strengthened the evaluation process particularly in the case of the borderline student. Newer faculty members related uneasiness in being specific and directive with "borderline" students. Experienced faculty offered suggestions on overcoming this fear and finding support among peers. Open discussion provided a forum for the exchange of ideas and philosophies. Though no definitive solutions were uncovered we judged this workshop to be a valuable learning experience with broad appeal across a very diverse faculty.

Clinical Competence↗
PubMed1987

Bridging the gap.

Explore the source record for details and available documents.

Community Health Nursing↗
PubMed1986

Feather and beak dystrophy and necrosis in cockatoos: clinicopathologic evaluations.

Several species of imported and captive-bred southeast Asian cockatoos with feather and beak disease (FBD) were evaluated. In recently emerging stained feathers from affected birds, intracytoplasmic magenta to basophilic inclusions of various sizes were found in macrophages and basophil-like cells within the pulp and feather epidermis. Occasionally, amphophilic intranuclear inclusions were seen within degenerated feather epidermal cells. On the basis of electron microscopic findings, intracytoplasmic inclusions were not membrane bound and consisted of crystalline arrays of viral particles (17 to 22 nm in diameter). On the basis of size and conformation, viral particles most closely resembled those of parvovirus or picornavirus. Consistent hematologic or serum enzyme differences were not found among affected or healthy cockatoos. Compared with findings in healthy cockatoos, cockatoos with FBD had significantly lower serum protein concentrations, and results of serum protein electrophoresis indicated that birds with FBD had significantly lower concentrations of prealbumin and gamma-globulin fractions. Mean pre- and post-ACTH plasma corticosterone concentrations of cockatoos with FBD were not significantly different from those of healthy cockatoos. In 8 of 9 affected cockatoos evaluated, serum T4 concentrations before and after thyrotropin stimulation were considered normal.

Animals↗
PubMed1986

Neonatal mastitis.

Forty-one cases of neonatal mastitis seen at Children's Hospital, Boston since 1947 have been analyzed and the literature since 1950 reviewed. All 41, like those in the literature, occurred in full-term infants 1-5 weeks of age, with a sex ratio of 2:1 (females:males). Bilaterality was rare (3) cases in this series, one in the literature review) and systemic spread or extramammary foci even rarer. The incidence has changed little in the past 35 years except for the larger number of cases in the 1950s. In the present series, all but a few cases have been caused by Staphylococcus aureus, and gram-negative enteric bacilli have not been seen. Therapy is surgical incision and drainage when fluctuance is present, but early treatment with appropriate intravenous antibiotics has apparently obviated the need for surgery in many recent cases. The prognosis for cure of the infection is excellent.

Female↗
PubMed1985

Aerodynamic assessment of the Henley-Cohn tracheoesophageal prosthesis.

In vitro airway resistance measurements were performed for eight Henley-Cohn voice prostheses. The results of these measures demonstrated that the Henley-Cohn device offers substantially less resistance to the flow of air than either the Blom-Singer or Panje devices. The lower overall resistance of the Henley-Cohn device was shown to be due to both its larger inner cross sectional area and to an improved valve tip design. The lower airway resistance of the Henley-Cohn prosthesis should theoretically result in more "efficient" production of esophageal voice than would be the case when using the Blom-Singer or Panje devices. However, the results of this investigation also point to the need for the development of methods which will enable investigators to evaluate the in vivo performance of tracheoesophageal prostheses.

Airway Resistance↗
PubMed1984

The cardiac surgical patient. Guidelines for assessment.

The nurses' assessments form the basis for clinical decision making. Table 2 is an example of how decisions can be made using assessment data. The emphasis is on the decision-making process rather than on specific therapeutic methods.

Cardiac Surgical Procedures↗
PubMed1984

A product of yeast RAS2 gene is a guanine nucleotide binding protein.

Yeast Saccharomyces cerevisiae contains two genes, RAS1 and RAS2, which show remarkable homology to mammalian ras genes. To characterize these gene products, we have expressed the RAS2 gene in yeast using an inducible GAL10 promoter. After labeling with [35S]methionine and immunoprecipitating with a monoclonal antibody Y13-259, which reacts with p21 encoded by mammalian ras genes, a major band having an apparent molecular weight of 41,000 is detected. This band has also been identified in cell-free translation products of polyadenylated RNA extracted from yeast cells grown in the presence of galactose. Crude extracts of cells expressing the RAS2 gene exhibit guanine nucleotide binding activity. This is detected by incubation with [3H]GDP followed by immunoprecipitation with the antibody Y13-259. The binding of labeled GDP is inhibited by a 20-fold excess of GDP, GTP, and, to a lesser extent, by UTP, a characteristic similar to that possessed by the mammalian ras proteins. However, the activity of the yeast protein differs from that of the mammalian proteins in its strong dependence on temperature. The guanine nucleotide binding activity provides an assay to purify the yeast protein.

Cloning, Molecular↗