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Biomedical subjects

M Wallner

Publications and source records attributed to M Wallner.

5 recordsLinked to original sources
PubMed1991

Molecular mechanism of protein kinase C modulation of sodium channel alpha-subunits expressed in Xenopus oocytes.

The mechanism of modulation of sodium channel alpha-subunits (Type IIA) by a protein kinase C (PKC) activator was studied on single channel level. It was found that: (i) time constants for channel activation were prolonged; (ii) inactivation remained virtually unchanged; (iii) peak sodium inward current was reduced as evidenced by calculation of average sodium currents; and (iv) time constants for current activation and decay were prolonged. (i), (iii) and (iv) were voltage dependent, being most prominent at threshold potentials. The data show that a voltage dependent action on the activation gate can account for the observed reduction of peak inward sodium current and prolongation of current decay in macroscopic experiments.

Animals↗
PubMed1990

Detection of prune-belly syndrome in a 35-year-old man: a rare cause of end-stage renal failure in the adult.

The clinical entity of prune-belly syndrome is mainly encountered in childhood. Here we present the case of a 35-year-old male patient with end-stage renal failure, the underlying cause of which being prune-belly syndrome. Apart from the typical triad of abdominal muscle deficiency, severe urinary tract abnormality, and cryptorchidism, a multitude of other abnormalities and malformations existed, especially of the skeletal and gastrointestinal systems. The major hypotheses regarding etiology and pathogenesis of the syndrome are briefly discussed.

Adult↗
PubMed1989

Doppler echocardiographic analysis of diastolic left ventricular function in dialysis patients and its relation to intradialytic hypotension.

Doppler echocardiography was used to evaluate left ventricular relaxation and filling in 20 patients on chronic maintenance hemodialysis. In comparison with 11 normal controls hemodialysed patients showed a marked prolongation of isovolumic relaxation period (83 +/- 23 ms vs 67 +/- 11 ms, P less than 0.01). Peak velocity of early diastolic filling was similar in both groups, but peak velocity of late ventricular filling due to atrial contraction was substantially increased in dialysis patients (66 +/- 23 cm/s vs 37 +/- 7 cm/s, P less than 0.01) and the ratio late to early peak velocity was significantly enlarged (0.97 +/- 0.35 vs 0.58 +/- 0.19, P less than 0.01). Although left ventricular mass index, as determined by Echo, was markedly increased in dialysis patients, no significant correlation was found between ventricular mass and indexes of diastolic function. When patients were divided into two groups on the basis of development of hypotension during dialysis clinical and echocardiographic characteristics were similar, although patients with dialysis hypotension (n = 9) were significantly older (53 +/- 9 years) than normotensive patients (n = 11, 42 +/- 14 years, P less than 0.05). Indexes of diastolic function showed a great overlap between the two groups, but ratio late to early peak velocity was significantly greater in patients with intradialytic hypotension (1.13 +/- 0.35 vs 0.83 +/- 0.32, P less than 0.05). It is concluded that dialysis patients exhibit significant alterations of left ventricular relaxation and diastolic filling as assessed by Doppler echocardiography which might be independent of left ventricular hypertrophy. Impaired diastolic function might contribute to intradialytic hypotension.

Adult↗
PubMed1978

A doctor at school.

Whether we are parents, teachers, doctors or other health professionals, we share a major concern in the growing number of adolescents who can be called 'alienated'. These people feel 'out-of-touch' with themselves, with others and with society. The causes and consequences are complex, but a greater awareness of the difficulties involved in growing up today, and a greater willingness for harmonious interaction between us all will be of benefit, not only to the adolescents we may help more effectively, but also to ourselves in our professional development. To the doctor, the school represents an influential environment for the adolescent that may play an important role in the aetiology of maladaptation. The school also represents an underutilized potential for health education and intervention, and for individual as well as multidisciplinary health care.

Adolescent↗