Biomedical subjects

M Walger

Publications and source records attributed to M Walger.

At least 19 recordsLinked to original sources

PubMed2007

[Experiments on prosody perception with cochlear implants].

BACKGROUND AND OBJECTIVE: Prosody has a myriad of linguistic functions and involves specific aspects of speech, such as stress, intonation and pauses. The underlying acoustic quantities (amplitude envelope, pitch frequency, and temporal structure) can be processed and transmitted by cochlear implants (CI) only to a limited extent. At present, no adequate tests are available in the German-speaking world for evaluation of the perception of prosodic elements. Different experiments have been conducted to address several prosodic cues, and the results are to be used as a basis for appropriate tests. METHODS: Various prosodic materials were used for the experiments. Discrimination was measured for minimal pairs differing in frequency and/or duration, accents in words and phrases, questions versus statements and phrasing. Measurements were performed in ten normal-hearing subjects and five with cochlear implants. RESULTS AND CONCLUSIONS: In all test modules, the subjects with normal hearing proved to have high discrimination rates of 96-100%. The test of word stresses was problematic because the results were influenced by different confounders. The other measurements did prove to be basically suitable for use in the subjects with implants. Early results revealed that the subjects with CI had few problems with prosodic cues based on the temporal structure, the outcome being similar to that of the subjects with normal hearing in these tests. In contrast, the performance of subjects with CI in perceiving prosodic cues based on amplitude variations and, especially, on alterations in pitch frequency was worse, even though some of them achieved very good results in these tests too. These preliminary tests can form the basis for development of a German-language prosody test battery with a limited number of subtests addressing different prosodic cues.

Acoustic Stimulation↗

PubMed2006

[Diagnosis and therapy of auditory synaptopathy/neuropathy].

Pathological auditory brainstem responses (lack of responses, elevated thresholds and perturbed waveforms) in combination with present otoacoustic emissions are typical audiometric findings in patients with a hearing impairment that particularly affects speech comprehension or complete deafness. This heterogenous group of disorders first described as "auditory neuropathy" includes dysfunction of peripheral synaptic coding of sound by inner hair cells (synaptopathy) and/or of the generation and propagation of action potentials in the auditory nerve (neuropathy). This joint statement provides prevailing background information as well as recommendations on diagnosis and treatment. The statement focuses on the handling in the german language area but also refers to current international statements.

Brain Stem↗

PubMed2005

[A measurement system for assessing binaural masking level difference (BMLD) in children].

BACKGROUND: The binaural masking level difference (BMLD) is defined as the contrast between homophasic and antiphasic signal conditions, and can be regarded as a measure for noise suppression by the auditory system. METHODS: An adaptive two interval forced choice (IFC) measurement method was designed to assess BMLDs in children. The target tone was a 500 Hz sine pip which was masked with narrow band noise. The presentation of homo- and antiphasic signals was staggered in order to take into account artefacts--such as changes in vigilance--in a similar manner for both conditions. RESULTS: Measurement was feasible in 57 out of 85 children (6-14 y.) with suspected auditory processing disorders. Mean BMLD was 7.4(+/-4.5 SD) dB. Five children revealed a BMLD close to 0 dB suggesting that they had no advantage in signal detection for the antiphasic condition. Eleven children were not able to cope with the task of measurement. In another 17 children, the measurements did not converge to a stable threshold. DISCUSSION: The proposed measurement method was feasible with most of the children. With slight modifications of the threshold convergence, this proportion can be further increased. Whether or not the large inter-individual scatter of the results is an expression of the heterogeneous clinical clientele can only be determined when normative data are available.

Acoustic Stimulation↗

PubMed2005

A new approach to pharmacological effects on ciliary beat frequency in cell cultures--exemplary measurements under Pelargonium sidoides extract (EPs 7630).

The ciliary beat frequency (CBF) is an important parameter of the defence mechanism of the mucociliary system. We present a new method to determine pharmacological effects on CBF in vitro. Ciliated cell cultures of human nasal epithelium were obtained from partial resection of hyperplastic inferior turbinates in rhinosurgery. An adherent monolayer culture of ciliated cells was present after 10 days in vitro. This study exemplary examines, if a special extract from the roots of Pelargonium sidoides (EPs 7630) has an effect on the CBF in vitro. The influence of three concentrations of the extract (1, 30, 100 microg/ml) was tested. EPs 7630 significantly and concentration-dependently increased CBF to 123% at 30 microg/ml and to 133% at 100 microg/ml compared to the equilibration phase (100%). After rinsing with extract-free medium the CBF of cultured cells returned to nearly the normal range. In future, drug manipulation of the CBF by local application of rhinologics could be a new therapeutical concept in the treatment of upper airway diseases.

Adrenergic alpha-Agonists↗

PubMed2004

[Identifying factors before the provision of hearing aids. Results from a pilot study].

OBJECTIVE: Systematic research on factors before the provision of hearing aids is scarce. In order to identify parameters which promote or impede the use of hearing aids, a questionnaire-based survey was conducted. SUBJECTS AND METHODS: A total of 35 randomly chosen, hard of hearing adults indicated for a hearing aid were examined. The importance of speech in quiet and in noise, wearing comfort, sound quality, appearance and costs, as well as expectations, willingness to use a hearing aid and reasons for and against provision were determined. RESULTS: Speech in noise and quiet were most important, followed by comfort of wearing and appearance of the aid. Expectations towards the hearing aids were in general high. The willingness to use hearing devices was positively affected by the expectation that it would improve quality of life and negatively by the amount of social activity of the person. The main reasons against the use of hearing aids were appearance and lack of confidence in hearing aid technology. CONCLUSIONS: This pilot-study identified several parameters which might affect willingness to use hearing aids. In particular, expectations towards the aids, personal attitude towards hearing and communication problems and the appearance of hearing aids should be subject to further examination.

Adult↗

PubMed2003

[Examination of binaural signal processing in normally hearing subjects using electrophysiological and psychoacoustical measurements].

BACKGROUND AND OBJECTIVE: At present, only a small number of validated, clinically usable methods for the assessment of binaural hearing capabilities exist. A proposed electrophysiological measure is the registration of the brainstem-based binaural difference potentials (BDP). PATIENTS/METHODS: The BDP is calculated as the difference between the binaurally evoked registration and the sum of the two monaural registrations. Detection and stability of the BDP were examined in 24 normally hearing adults within the framework of conventional registration of auditory brainstem responses. Furthermore, the influence of interaural time differences (ITD) on the BDP was determined. In addition, lateralization of the subjects was assessed using a psychoacoustical method. RESULTS: The components of the BDP could be detected in almost all of the subjects. Moreover, they showed sufficient test-retest reliability. The impact of ITD,which causes lateralization of the stimulus,was clearly detectable for the latencies and the amplitudes of the BDP. CONCLUSIONS: Binaural difference potentials, which are easily and reliably detectable reveal a relationship to the outcome of psychoacoustical assessment of lateralization and have the potential to provide a measure for binaural hearing capacity.

Acoustic Stimulation↗

PubMed2002

Rehabilitation of hearing and communication functions in patients with NF2.

Most patients with neurofibromatosis type 2 (NF2) lose hearing either spontaneously or after removal of their neurofibromas. The patient may benefit from conventional hearing aids if, due to modern microsurgery and intraoperative monitoring the integrity of the cochlea and the 8th nerve is preserved. With lost auditory function but preserved electrical stimulibility of the 8th nerve a cochlear implant may be appropriate. But if the patients have no remaining 8th nerve to stimulate, there is no benefit from cochlear implants. Until some years ago, vibrotactile aids, lip-reading, and sign language have been the only communication modes available to these patients. With auditory brain stem implants it is now possible to bypass both the cochlea and the 8th nerve and to stimulate the cochlear nucleus directly. Stimulation of the devices produces useful auditory sensations in almost all patients. Testing of perceptual performance indicated significant benefit from the device for communication purposes, including sound-only sentence recognition scores and the ability to converse on the telephone. Also lip-reading is significantly improved with brain stem implants. The successful work of an auditory brainstem program center depends very much on the close interdisciplinary collaboration between the Departments of Neurosurgery and ENT-surgery. In the future new developments like speech processing strategies and new designed electrodes accessing the complex tonotopic organization of the cochlear nucleus may further improve rehabilitation in these patients who would have been deaf some years ago.

Auditory Pathways↗

PubMed2001

[Loudness scaling in children].

BACKGROUND AND OBJECTIVE: Loudness measurements in children have been carried out using different psychoacoustical methods. Besides absolute magnitude estimation (AME) and cross modality matching (CMM) category and non-category loudness scalings have been performed. However, there is a lack of systematic evaluation in loudness scalings with children. PATIENTS/METHODS: A clinically feasible categorical method is presented which was evaluated in 10 normally hearing children of 7 to 8 years. Furthermore, measurements with hearing disabled children were performed in the framework of hearing aid evaluation. RESULTS: Normal hearing children scaled slightly louder than a group of adult subjects with normal hearing. Regarding the shape of the loudness functions measured they were very similar. Particularly, they showed a steeper course at higher levels than for low input signals. Intraindividual scatter of the loudness judgements was larger for children than for adults. However, high correlation appeared between the data across test and retest. Hence, the outcome of the scalings appears to be sufficient reliable. CONCLUSIONS: Clinical measurements confirmed that the method is appropriate for children from approximately 5-10 years. Loudness judgements became more consistent and more subtly differentiated with increasing age and decreasing hearing loss. Especially with view of hearing aid evaluation the method can give valuable indications because of the possibility to directly measure individual loudness over a broad range of levels and frequencies.

Adult↗

PubMed2001

Progressive hearing loss in hearing impaired children: immediate results of antiphlogistic--rheologic infusion therapy.

OBJECTIVE: The question whether progressive sensorineural hearing loss during childhood is the fateful course of a main illness has been discussed controversially over 60 years. No medicamentous therapy with satisfactory results has been described in the literature. The goal of this study was to determine whether an infusion therapy, developed for the treatment of sudden hearing loss in the elderly, can induce recovery after progression in sensorineural hearing loss during childhood. METHODS: Out of 20 children suffering from acute progression in sensorineural hearing loss, seven children were treated with an infusion therapy containing prednisolone, pentoxifylline and a plasma expander (group I), and 13 children were not treated (group II). All children were advised not to use hearing aids for 6 weeks. RESULTS: In group I, we observed partial to complete restoration of hearing threshold towards the original hearing threshold given by previous routine controls in 6/7 children. In group II, only three children recovered, with the state of ten children's' hearing loss remaining unchanged. The long-term follow-up, however, showed no distinct difference in either group. CONCLUSION: Infusion therapy can be helpful when treating acutely progressing sensorineural hearing loss during childhood. The benefit for communicative competence has to be discussed. Further studies should be conducted.

Case-Control Studies↗

PubMed2001

Using conjoint analysis to examine the importance of hearing aid attributes.

OBJECTIVE: To introduce conjoint analysis (CA) as a method to explain choice decisions of hearing aid users and to measure the contributions of different hearing aid attributes involved. DESIGN: The study was conducted using CA, a method that is well established in marketing, but has not been used for hearing aid research. CA examines the contributions (importance) various attributes make to overall preference judgements. It is based on the premises that objects (i.e., hearing aids) can be described as different combinations of several attributes. The relative importance of the attributes is estimated from integral judgements of hypothetical hearing aids. The advantages of CA are a more realistic presentation of complete products instead of isolated attributes and the consideration of trade-offs between the features. The following attributes selected from 12 features in a prestudy were included in the application: speech perception in quiet, speech perception in noise, handling, sound quality, localization, and feedback. 93 randomly chosen experienced hearing aid wearers participated in the survey. RESULTS: It was found that the attributes concerning speech perception were by far most important. Speech discrimination in quiet and in noise were almost equally significant and contributed with 56% to the preference decisions of the subjects. The remaining attributes showed values in the range of 10% to 12%. When comparing various subgroups dependent on age, sex, hearing loss, satisfaction, etc., significant differences concerning the preferences were found. Elder and female subjects attached greater importance of the attribute "handling" whereas younger patients judged "speech in noise" more important. In general, subjects with greater hearing loss considered speech intelligibility in quiet to be more important than in noisy surroundings. Moreover, sound quality seems to be a significant indicator for satisfaction with the hearing aid. CONCLUSIONS: This study proposes CA as a survey technique to examine individual preferences for hearing aids. Several assumptions about the importance of hearing aid features for different groups of users could be confirmed quantitatively. Segmentation showed valid results depending on socio-demographic and user-specific parameters. The method used and the results are of interest for audiologists as well as the hearing aid industry. They provide valuable tools for future hearing aid design and should be considered in the development of self-assessment inventories.

Correction of Hearing Impairment↗

PubMed2000

[Categorical loudness scaling within the scope of hearing aid management].

The loudness perception of patients with hearing aids was measured with a one-stage category loudness scaling procedure. Data were obtained from 102 ears and were studied primarily in older patients who represented the majority of patients with hearing disorders evaluated in our department. In all, 75% of the patients were older than 45 years and had a mean age of 58 years. The reduction of dynamics at high frequencies was considered to be typical for age-related hearing disorders and was easily quantified with loudness scaling. Findings demonstrated that prediction of recruitment was not possible from pure-tone thresholds or even together with uncomfortable loudness levels, since the slopes of the level-loudness functions revealed a high interindividual variability. In contrast, the desired compression ratio can be easily calculated with data from the loudness scaling. In this study the loudness perception of patients with mainly non-linear hearing aids fitted with customary procedures was evaluated. The benefit from the hearing aids was proven with the outcome from the loudness scaling, with testing also allowing for a better fitting of the aids.

Adult↗

PubMed2000

[Effect of monaural deprivation on maturation of the auditory pathway in the Mongolian gerbil (Meriones unguiculatus)].

Several investigations prove that monaural acoustic deprivation induces detrimental changes in the auditory pathway. So far the major interest focused on degenerative processes on the deprived side, while effects on the contralateral untreated side were not taken into consideration. This ontogenetic study investigates effects of early monaural acoustic deprivation on the functional development of the acoustically evoked auditory brainstem response (ABR) in the Mongolian gerbil. Young gerbils were deafened by a single intracochlear application of neomycin sulfate. The ABR development on the contralateral side differed in a late developmental period from that of normally hearing animals. These changes persisted until adulthood. Between day 55 and day 90 a significant 5 dB decrease of the ABR thresholds and a significant shortening of the interpeak latency II-V occurred. The results confirm that a complete monaural deprivation during the sensible or critical period leads on the contralateral side to plastic or compensatory changes in the auditory brainstem.

Age Factors↗

PubMed2000

[Standardized measurement of sound transmission of different middle ear prostheses].

The sound transmission properties of three different commercially available middle ear implants and the prototype of a complete middle ear prosthesis (CoMEP) were evaluated with a special measurement system that permits standardized conditions. This system uses a mechanical middle ear model (MMM) which approximates the impedances of the tympanic membrane and inner ear. The implants were fitted under defined conditions into the MMM. Displacement of the artificial stapes footplate of the MMM was measured with an optical probe. The measurements of different middle ear prostheses showed that the mass of the implant was the most important factor for optimum high frequency transmission. The lightest implant (4 mg, titanium) showed the best results. The CoMEP revealed the highest sensitivity because of a slight enlargement of the diameter of the artificial tympanic membrane. These findings show that the CoMEP is able to restore sound transmission to a normal range. In a second experiment one of the implants was fitted into the MMM with different forces. The increase of stiffness produced a slightly better high frequency transmission at the expense of low frequency sensitivity. Hence, the fitting of the implant may not be too stiff because of its loss of mobility within a significant frequency range.

Acoustic Impedance Tests↗

PubMed2000

[Using the Mongolian gerbil (Meriones unguiculatus) as an animal model in ontogenetic cochlear implant research].

One of the problems when providing prelingually deafened children with a cochlear implant is to find the optimal moment for the implantation in order to make optimal use of the sensitive phase in the maturation of the auditory system and to achieve the maximum improvement of hearing. Ontogenetic questions can be investigated in animal experiments under controlled conditions. In the present study an animal model (gerbil, Meriones unguiculatus) was established to simulate the situation of prelingually deafened children and to examine the influence of chronic electrostimulation on the development of the auditory pathway. We used species specific sounds for chronic stimulation to simulate significance of human language in our animal modell. A daily two-hour electrostimulation during the ontogenesis of early deafened animals lead to a partial compensation of the functional degeneration of the auditory pathway, which can be observed in totally deafened animals. This animal model provides an elaborate test design which can be used in CI research for the investigation of numerous problems.

Animals↗

PubMed2000

[Clinical comparison of a digital with an analog hearing aid].

The benefit of innovative hearing aid technology can be evaluated in clinical trials. The present study describes the comparison of a new digital hearing aid with an analogue device serving as a reference. The tests were carried out with 15 experienced hearing aid wearers. To prevent the influence of different fitting algorithms such as prescriptive or loudness-based the digital devices were not renewed fitted but their level- and frequency-depending gain was adjusted to that of the reference. Different tests concerning loudness perception (category loudness scaling) speech discrimination in noise (the Göttingen sentence test) and self-assessment of the benefit by questionnaires were performed. All tests yielded slightly better results for the digital hearing aid. The speech audiometric evaluation showed somewhat better discrimination for the test-device. The questionnaires yielded a marked preference for the digital device. Because the study was not blinded influences due to the knowledge of the subjects of testing a new technology generally can occur. On the other hand, the question arises whether present audiometric tests sufficiently consider signal processing of modern hearing systems. Furthermore, one has to take into account that only a few of the features of digital technology such as noise-reduction and feedback-cancellation were considered in this study to allow for a sensible comparison. Because of the large number of possibilities offered by digital technology additional benefit by the hearing aid can be expected.

Analog-Digital Conversion↗

PubMed2000

Epidemiology of hereditary hearing disorders in childhood: a retrospective study in Germany with special regard to ethnic factors.

Recent studies have revealed marked differences in the prevalence of hearing impairment in childhood. It remains unknown whether this is caused by geographic, sociocultural or ethnic factors. In order to provide consistent data, 314 children in residence at a school for hearing impaired children of a well-defined German area were investigated retrospectively. We estimated an overall prevalence of .43/1000 of hearing impairment for this area. A striking variability between different nationalities could be observed. For German children, the prevalence was .36/1000, for Turkish 1.04/1000 and for Italian children 1.37/1000. Hereditary hearing losses and, in particular, autosomal recessive caused hearing disorders were the most common cause of hearing impairment in foreign but not in native children. One reason might be the frequency of marriages between relatives resulting from the social isolation of the foreign groups in German society.

Adolescent↗

PubMed2000

[KTQ--a project on hospital accreditation].

"KTQ--Cooperation for transparence and quality in hospitals" is a joint project of the German Hospital Federation (DKG), of the Substitute Sickness Funds Associations (VdAK/AEV) and of the German Medical Association (BAK). Further partners are the German Nursing Care Council (DPR) and pro-Cum Cert--an organization of charity hospital owners. Since September 1998 the project is financially supported by the Federal Ministry of Health (BMG). The project is still on an experimental status. The participation will be voluntary for hospitals. The KTQ--Accreditation process consists of a self assessment followed by an external assessment--both on the basis of an identical criteria-catalogue. The accreditation process has to be repeated regularly. Accredited hospitals have to publish their results through a quality-report. Since May 2000 the project is tested by 25 hospitals. It is evaluated under the guidance of a scientific institute (IMI, Tübingen). The KTQ--project will be applicable in routine in 2001.

Accreditation↗

PubMed1999

Standardized measurements of the sound transmission of middle ear implants using a mechanical middle ear model.

Several ways to evaluate the sound transmission properties of middle ear implants are now established. Besides computer-based simulations using acoustic and electrical analog circuits or finite element analysis, measurements can be performed with temporal bone preparations. Experiments with these preparations consider various anatomical properties, but a large number of parameters influence the outcome of measurements. To facilitate standardized measurements, a mechanical middle ear model was developed that allows comparison of the transfer function of middle ear implants on defined conditions. The model approximates the impedances of the tympanic membrane and inner ear with the aid of thin, flexible membranes. The implants are fit between the membranes, and displacement at an artificial stapes foot-plate is measured with an optical probe. Fundamental influences on the sound transmission properties of nine different middle ear implants (total ossicular replacement prostheses) were examined. Although the material and shape were different, some of the prostheses revealed very similar transfer functions. The mass of the implant showed the largest influence on sound conduction. With a higher mass, the frequency area above approximately 1 kHz was found to be significantly deteriorated. The lightest implant used was 4 mg and showed the best overall results. These findings show that middle ear prostheses should be as light as possible for optimum high-frequency transmission.

Acoustics↗