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Biomedical subjects

M Wagner

Publications and source records attributed to M Wagner.

At least 865 records · Page 48Linked to original sources
PubMed1989

Structure-activity relationships of new analogues of arecaidine propargyl ester at muscarinic M1 and M2 receptor subtypes.

1. The potency of arecaidine propargyl ester (APE) and of several analogues containing a modified ester side chain has been assessed at M1 and M2 muscarinic receptor subtypes. APE was shown to act as a potent agonist at ganglionic M1 receptors in the pithed rat, at M2 receptors in guinea-pig isolated atria (-log EC50 = 8.22) and ileum (-log EC50 = 7.77). 2. The arecaidine 2-butynyl and 2-pentynyl esters were approximately equipotent with APE at M1 and M2 receptors, whereas the 2-hexynyl derivative was found to be less potent than APE in atria (-log EC50 = 6.80) and ileum (-log EC50 = 6.70) by about one order of magnitude. The 2-heptynyl and 3-phenyl propargyl esters exhibited no agonist actions in atria and ileum. 3. Shifting the triple bond from the 2 to the 3 position and introducing a bulky group at position 1 of the ester side chain of APE and analogues resulted in competitive antagonists (pA2 ranging from 4.9 to 7.3). 4. APE and its 2-butynyl analogue showed some agonistic selectivity for cardiac M2 receptors (potency ratio, ileum/atria = 2.8 and 4.6 respectively). All antagonists in this series of compounds were not selective in terms of affinity since their pA2 values at cardiac and ileal M2 receptors were similar (potency ratios, ileum/atria = 0.4 to 1.2).

Animals↗
PubMed1989

Criteria for classifying normal and degenerated lumbar intervertebral disks.

The purpose of this study was to develop criteria for distinguishing normal and degenerated lumbar intervertebral disks. Cryomicrotome sections from and magnetic resonance images of 31 cadavers were reviewed. The immature nucleus pulposus, found up to age 2 years; the transitional nucleus pulposus, found in teenagers; and the adult nucleus pulposus were associated with an intact anulus fibrosus without tears except for small concentric or transverse tears in the periphery of the anulus fibrosus. Discoloration of the nucleus pulposus, diminishing disk height, and diminishing signal intensity were associated consistently with a radial tear of the anulus fibrosus. The severely degenerated nucleus pulposus was associated also with a radial tear or complete disruption of the anulus fibrosus. The results suggest that intervertebral disk normally progresses from the immature to the transitional to the adult nucleus pulposus. When a radial tear develops in the anulus there is shrinkage and disorganization of fibrocartilage in the nucleus pulposus and replacement of the disk by dense fibrous tissue and cystic spaces.

Adolescent↗
PubMed1989

[Regional living conditions, migration, and family composition].

"On the basis of life history data of German birth cohorts born 1929-31, 1939-41, and 1949-51 hypotheses about the relation between regional context, migration and family formation are tested. Results of proportional hazard models do not show significant regional effects on first birth rates for stayers when sociostructural variables are controlled for. However, social background and employment status of [women], which are proved to be important factors concerning family formation, reflect differential regional opportunities on the labor market. For men including the indicator of marriage in the model makes the regional effect insignificant." The impact on fertility of rural or urban residence and of rural-urban migration is analyzed. (SUMMARY IN ENG)

Cohort Studies↗
PubMed1989

[Computer-assisted tumor documentation, after-care and medical correspondence in radiotherapy].

Without electronic data processing the recording and statistical evaluation of a great number of tumor patients is only hardly possible. A tumor register and follow-up program is described which has been established for radiotherapy during the development of a national tumor register organized at present. This tumor register also serves as a basis for letter-writing to physicians. The software can easily be adapted to the needs of every hospital because a commercial data bank system has been used. The data input and output is carried out over several terminals. The hardware and software system as well as the incorporation of the data bank into the national tumor register are described.

Aftercare↗
PubMed1989

[Stability of the spine following osteosynthesis with internal fixation. Case report].

Fractures of the first and third lumbar vertebrae were primarily reduced and stabilized with a Fixateur interne (The XII-LIV) and filled with transpedicular bone grafts in a 21 years old girl. Nine months after this injury she fell from the fifth floor sustaining a flexion-distraction fracture of Th XI whereas the lumbar spine as well as the Fixateur interne remained intact. Stabilization by a Fixateur interne was carried out again. This is an example of the broad application of Fixateur interne in lower thoracic and lumbar spine traumatology and for the high degree of stability of the Fixateur system.

Adult↗
PubMed1989

[CEA studies in endometrial cancer].

In the years 1983 to 1986 concentrations of CEA in serum samples of 63 female patients with endometrial cancer have been estimated with help of a radioimmunoassay. In all histopathological stages 25 per cent elevated CEA-concentrations could be found pretherapeutically. It is given the semilogarithmic representation of the CEA-values of the individual basic lines in the posttherapeutical follow up. Main field for estimations of CEA-concentrations in serum is only the performance of a posttherapeutical monitoring of the operated and irradiated endometrial cancer.

Adenocarcinoma↗
PubMed1989

[Surgical management of pertrochanteric fractures with the dynamic hip screw of the AO type].

Since 1981 we have been using the dynamic hip screw (DHS) for surgical treatment of pertrochanteric fractures. After presentation of the implant and the operative technique the postoperative treatment is discussed. Immediate mobilization of the injured leg with weight-bearing is extremely important. Up to the end of 1986 we had used the DHS in 509 patients, whose average age was 75 years. During the hospital stay 31 patients died. Complications in the form of an infection occurred in 11 cases. Technical mistakes during surgery and breakage of the implant were each observed in two cases. After a period of 11 months patients were observed for assessment of the described technique. This examination was possible in 193 patients, showing excellent results presented in this paper. With full weight-bearing DHS ensures constant bony contact of the fracture fragments by means of the sliding mechanism. The advantages of the DHS are (1) relatively simple surgical technique; (2) low rate of complications; and (3) early mobilization without danger of complications resulting from the implant.

Aged↗
PubMed1989

[Autoclaved bone grafts in prosthesis replacement of the hip].

Bone defects of the acetabulum caused by loosening of the socket of a total hip prosthesis can be filled in with autoclaved homologous cancellous bone grafts. Five months after surgery a radiological change in the bony structure is visible. Histological examination shows that new bone is formed around the autoclaved bone.

Acetabulum↗