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Biomedical subjects

M Wagner

Publications and source records attributed to M Wagner.

At least 667 records · Page 37Linked to original sources
PubMed1991

Too many cooks batter technology assessment.

The bustling activity and interest in technology assessment obscures two growing problems. More than 70 groups, sporting a variety of agendas, are involved in assessing new devices, drugs and procedures; variations in the information they seek or the methods they use sometimes produce findings that conflict or can't be compared.

Health Services Research↗
PubMed1991

Expression and subcellular location of native and mutant hTNF alpha proteins in Escherichia coli.

Several mutant hTNF alpha genes were constructed by deletion and stepwise reconstitution of regions coding for C-terminal sequences. The mutant hTNF alpha proteins behaved differently from native hTNF alpha when expressed in Escherichia coli. They were either sensitive to proteolytic degradation or formed insoluble aggregates depending on the strains and conditions used for expression. By contrast, native hTNF alpha was always present in a soluble form and had a tendency to associate with the cytoplasmic membrane. It was even transported to the periplasmic space in E. coli as shown by both cell fractionation and immunoelectron microscopy. The different behaviour of mutant hTNF alpha proteins probably results from a disturbance of protein folding.

Amino Acid Sequence↗
PubMed1991

Groups see more use of pacts, target alternate sites. 1991 group purchasing survey.

Purchasing groups and alliance purchasing programs accounted for $11.1 billion in goods and services bought by hospitals last year, according to MODERN HEALTHCARE's 1991 group purchasing survey. Trends included the folding of additional hospital departments into central purchasing and increased targeting of alternate-site markets. The responses also documented significant growth and realignment in the industry.

Data Collection↗
PubMed1991

Researcher seeks uniform mattress ratings.

Are special mattresses and pads truly effective in reducing the problems associated with pressure scores? A California-based group says there's no effective way to tell whether the products are living up to their claims, and the group's head is seeking an improvement in the measures used to assess those products.

Bedding and Linens↗