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Biomedical subjects

M W Carter

Publications and source records attributed to M W Carter.

52 records · Page 3Linked to original sources

A retrospective epidemiological study of mortality at a large western copper smelter.

In comparing the smelter with the mine, concentrator, and State of Utah, it was found that they were very similar in the percentage of deaths due to all causes except lung cancer; 7.0% of all deaths at the smelter were due to lung cancer compared to 2.2% for the mine, 2.2% for the concentrator, and 2.7% for the state. The excess at the smelter was statistically significant. Approximate age-adjusted death rates were obtained for various causes of death. The rates for the smelter are higher than for the mine and the state for lung cancer and for all causes combined. The average age at death for smelter workers is nearly the same as for mine employees, even for those who died of lung cancer. Smoking data was examined and there was no indication of a smoking synergism. Cumulative exposure indices for SO2, H2SO4 mist, As, Pb, and Cu were computed for each deceased smelter worker based n the length of time he worked in each of 12 major areas. Those who died of lung cancer had the highest average exposure index for all five constituents. Stack emission data showed much higher levels of As and SO2 prior to 1959.

Adult↗

Estimation of the life span of red blood cells in the growing animal in different nutritional states.

In this study the model of Shemin and Rittenberg for estimating the life span of red blood cells was extended so that non-steady-state conditions, exemplified by growth or changing physiological states, might be considered. The parameters were estimated by use of the modified Gauss-Newton method. The biological data that were used came from growing sheep in different physiological states with regard to copper. The model was extended to include changes in total blood hemin and changes in blood hemin synthesis that may occur with time. In the present study a linear function was taken as a first approximation. The model appeared to be a sufficiently good approximation in the study reported herein. It was found, however, that the parameters associated with changes in hemin should be estimated from ancillary measurements such as blood volume, Hb, body weight, etc., in order to obtain a good fit or definition of the model.

Animals↗