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Biomedical subjects

M W Carney

Publications and source records attributed to M W Carney.

At least 37 records · Page 2Linked to original sources
PubMed1987

Ganser syndrome and its management.

The literature on the Ganser syndrome is reviewed, and a case history is described. A brief hospital admission is worthwhile for patients with this syndrome, but planning and persuasion are needed.

Adult↗
PubMed1986

Affective illness and S-adenosyl methionine: a preliminary report.

S-Adenosyl methionine may well have an antidepressant action beyond a placebo effect but this is virtually confined to endogenous depression. This should be subjected to further study. Our own double-blind placebo-controlled study is still incomplete. The indications are that SAM specifically affects folate, dopamine, and serotonin metabolism as well as activating and switching brain mechanisms. This suggests exciting prospects for further investigations. SAM is a nontoxic physiological metabolite virtually free of side effects.

Adult↗
PubMed1985

Clinical and subclinical thiamine deficiency in clinical practice.

Six patients with gross thiamine deficiency found during normal psychiatric practice in England are described. Two surveys of newly admitted psychiatric patients are recounted. A major degree of biochemical deficiency, with or without minimal clinical manifestations, was found. Only three (1%) of 326 patients surveyed had gross clinical deficiency. It is thought that severe thiamine deficiency, though rare in the Western countries, has not been eradicated. Deficiency may cause psychiatric conditions like Wernicke's encephalopathy or may be a secondary feature in mental illness due to anorexia, in reduced food intake, and in poor nutrition. The importance of being aware of the possibility for correct diagnosis is emphasised.

Aged↗
PubMed1984

Methylation and mood.

S-adenosylmethionine (SAM) has antidepressant properties. The commonest neuropsychiatric complication of severe folate deficiency is depression. These independent observations suggest that methylation in the nervous system may underlie the expression of mood and related processes and may be implicated in some affective disorders; suggest new biological approaches to the understanding and treatment of some affective disorders; and may explain why methionine sometimes aggravates schizophrenia.

Anemia, Megaloblastic↗
PubMed1984

A 5-year follow-up study of chronic schizophrenics treated with clopenthixol decanoate.

Twenty-three chronic schizophrenic patients were followed-up over periods up to 5 years (1978-1983) while receiving treatment with depot injections of clopenthixol decanoate in doses ranging from 100 to 600 mg every 2 to 4 weeks. The highest single dose given was 1600 mg. Improvement in psychotic symptoms occurred progressively over the 5 years, with reduction in mean overall symptom score for schizophrenia from 7.43 to 0.88. Mean side-effects scores decreased over the same period from 2.0 to 0.5. After 5 years, 10 patients were still maintained on clopenthixol decanoate. Although during the first 2 months there was little improvement in 'negative' or 'loss' symptoms, improvement was similar in 'positive' and 'negative' symptoms after 5 years. Clopenthixol decanoate appeared to have a better calming effect than that encountered with flupenthixol decanoate. At higher doses, it caused drowsiness and subdued hostility and aggression.

Adult↗
PubMed1983

Clinical features and motives among 42 artifactual illness patients.

This paper describes the salient clinical features and histories of 42 patients whose artifactual condition gained them admittance to hospital. Most were female, single, separated or divorced, emotionally deprived in childhood and/or adulthood, and 'psychopathic'. Also common were poor work records, court convictions, drug and/or alcoholic histories and aggressive traits and/or acts. However, 50 per cent were in caring professions and 28 per cent socially conformist. Distinct subgroups were wanderers, non-wanderers, single-system and multiple-system patients, haemorrhagic and psychiatric patients. Seventy-four per cent seemed to be experiencing severe unacknowledged sexual and/or marital problems, 32 per cent sought more general attention, 10 per cent were compensating for loss of parents or spouse, and 12 per cent were escaping things or trying to obtain things retrospectively. Haemorrhagic and psychiatric subgroups of artifactual illness had not previously been described. Non-wanderers were significantly more cooperative in follow-up than wanderers. The psychopathology of this disturbance is discussed.

Adolescent↗
PubMed1982

Thiamine, riboflavin and pyridoxine deficiency in psychiatric in-patients.

One hundred and seventy-two successive admissions to a district general hospital psychiatric unit were examined. Routine psychiatric, drug and dietary histories were taken and signs of avitaminosis B specifically noted. Red cell transketolase (for thiamine deficiency), glutathione reductase (for riboflavin deficiency) and aspartate transaminase (for pyridoxine deficiency) were measured. Of the patients, 53 per cent were deficient in at least one vitamin, 12 per cent in more than one (30 per cent in thiamine, 27 per cent in riboflavin and 9 per cent in pyridoxine). Schizophrenics and alcoholics were significantly over-represent in those patients low in thiamine and in more than one vitamin. Patients with an affective disorder had low riboflavin and low pyridoxine. It is suggested that affective changes are characteristic of riboflavin and pyridoxine deficiency.

Aspartate Aminotransferases↗