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Biomedical subjects

M W Brown

Publications and source records attributed to M W Brown.

At least 127 records · Page 7Linked to original sources
PubMed1978

Amnesic effects of intravenous diazepam and lorazepam.

The amnesic effects of 2 benzodiazepine drugs, diazepam (Valium) and lorazepam (Ativan), have been investigated. Some of the effects were similar to those of certain clinical amnesic syndromes. The effects were more extensive than previous work has indicated.

Adult↗
PubMed1977

Responsiveness of neurones in the hippocampal region of anaesthetised and unanaesthetised cats to stimulation of sensory pathways.

The responses to sensory stimuli and to shocks to the optic pathways have been studied for 399 units in the hippocampal region of 19 cats. 172 units were recorded from anaesthetised cats and 229 from 7 unanaesthetised cats. In the unanaesthetised animals the proportions of units responding were high (60%) and did not differ significantly between regions for each type of stimulation investigated: visual, auditory and optic chiasma shocks. The proportion of units responsive to chiasmatic stimulation was related to the background firing rate. The latencies and duration of the responses were relatively long and variable. Both increases and decreases in responsiveness occurred. In a number of units response were erratic, sometimes being brisk and at other times totally absent. Responses during one series of stimuli were not always similar to those during a subsequent series. A higher proportion of units responded decrementally to a series of sensory stimuli than to a series of shocks to the optic chiasma. Movement by the animal was wihtout consistent effect on unit activity. Responses were markedly influenced according to whether or not the cat looked intently at an object. An important determinant of HR unit responses was the state of arousal, the effect being regionally distributed. In anaesthetised animals the proportions of responding units were substantially lower and the responses were weaker than those in the unanaesthetised cats.

Anesthesia, General↗
PubMed1975

In vitro antibacterial activity of drugs against human intestinal anaerobic bacteria.

The in vitro antibacterial activity, against the major groups of anaerobic fecal bacteria, of a series of drugs was examined by an agar diffusion test and the minimum inhibitory concentration (MIC) test. Only the phenothiazines and amitriptyline showed any marked antibacterial activity, the MIC's being in the 40-640-mu-g/ml range. It is suggested that the detergent nature of the molecules of these drugs in aqueous solution is responsible for the observed antibacterial activity.

Amitriptyline↗
PubMed1974

Propylene oxide as sterilizing agent.

Liquid propylene oxide added to a variety of disinfectant solutions resulted in a significant reduction of the bacterial spore content of these solutions.

1-Propanol↗