Biomedical subjects

M W Bojanowski

Publications and source records attributed to M W Bojanowski.

6 recordsLinked to original sources

PubMed2001

Scalp nerve blocks decrease the severity of pain after craniotomy.

UNLABELLED: Up to 80% of patients report moderate to severe pain after craniotomy. In this study, we assessed the efficacy of scalp block for decreasing postoperative pain in brain surgery. Thirty patients scheduled for supratentorial craniotomy were enrolled. They were randomly divided into two groups: Ropivacaine (scalp block with 20 mL of ropivacaine 0.75%) and Saline (scalp block with 20 mL of saline 0.9%). Anesthesia was standardized. The scalp block was performed after skin closure and before awakening. Postoperative pain was assessed at 4, 8, 12, 16, 20, 24, and 48 h by using a 10-cm visual analog scale. Analgesia was provided with sub- cutaneous codeine as requested by the patient. Average visual analog scale scores were higher in the Saline group as compared with Ropivacaine (3.7 +/- 2.4 vs 2.0 +/- 1.6; P = 0.036). The total dose of codeine did not differ, nor did the duration of time before the first dose of codeine was required in the Ropivacaine (571 +/- 765 min) versus Saline (319 +/- 409 min; P = 0.17) group. In conclusion, we found that postoperative scalp block decreases the severity of pain after craniotomy and that this effect is long lasting, possibly through a preemptive mechanism. IMPLICATIONS: Up to 80% of patients report moderate to severe pain after craniotomy. This randomized double-blinded study demonstrated that ropivacaine scalp block decreases the severity of pain after supratentorial craniotomy.

Adolescent↗

PubMed1999

Knock-out of the cyaY gene in Escherichia coli does not affect cellular iron content and sensitivity to oxidants.

Friedreich ataxia is a recessively inherited neurodegenerative disease caused by deficiency of a highly conserved mitochondrial protein, frataxin. Frataxin deficiency results in mitochondrial iron accumulation and oxidative stress. Frataxin shows homology with the CyaY proteins of gamma-purple bacteria, whose function is unknown. We knocked out the CyaY gene in Escherichia coli MM383 by homologous recombination and we generated an E. coli MM383 strain overexpressing CyaY. Bacterial growth, iron content and survival after exposure to H2O2 did not differ among these strains, suggesting that, despite structural similarities, cyaY proteins in bacteria may have a different function from frataxin homologues in mitochondria.

Amino Acid Sequence↗

PubMed1997

Endovascular treatment of ophthalmic segment aneurysms with Guglielmi detachable coils.

PURPOSE: To evaluate the safety and efficacy of endovascular treatment of ophthalmic segment aneurysms with Guglielmi detachable coils (GDCs), as well as the primary indications for such treatment. METHODS: We conducted a prospective study of 26 patients with 28 aneurysms of the ophthalmic segment in whom treatment with GDCs was attempted. Anatomic results were measured by statistical analysis of variance for such factors as age, sex, presence of subarachnoid hemorrhage, anatomic type (ophthalmic or superior hypophyseal), size of aneurysmal sac, and width of aneurysmal neck. Clinical evaluation and control angiography were performed at 6 and 18 months. RESULTS: Overall, complete occlusion was obtained in 14 aneurysms (50%) and small residual necks were left in 11 aneurysms (39%). Three treatment attempts failed (11%). Complete occlusion was obtained in 76% of small-necked aneurysms as opposed to 9% of aneurysms with a large neck. The best predictor of anatomic result was the size of the aneurysmal neck. Complete occlusion was obtained in 85% of superior hypophyseal aneurysms of the paraclinoid variant. One permanent complication was related to treatment. CONCLUSION: Endovascular treatment with GDCs appears to be a safe and efficient alternative approach for ophthalmic segment aneurysms, especially for paraclinoid variants of superior hypophyseal aneurysms, which tend to have a small neck.

Adult↗

PubMed1995

[Spontaneous dissection of the cervical arteries].

The spontaneous cervical artery dissection (SCAD) is one of the main causes of cerebro-vascular accident in the young adult. It may results from minor cervical trauma. The pathophysiological basis of the neurological complications remain unclear. For that reason, the treatment of SCAD is often empirical. In a retrospective study (1984-1994), we have reviewed 20 cases admitted to Notre-Dame Hospital for a SCAD confirmed by angiography. The initial clinical diagnosis was missed in 65% of the cases despite a suggestive symptomatology (headache 80%, hemiparesis 65% and Horner 45%). We have studied the clinical evolution as related to blood pressure, volemia, haematocrit and the administered treatment (aspirin, Coumadin). 60% of the patients (mean age 39) deteriorated in the hours following their admission. Their was one death (5%) and 85% had neurological sequelae. This study suggest that SCAD is a potentially serious disease. A delayed diagnosis may lead to a poor prognosis. Early aggressive treatment aiming at an optimal cerebral perfusion could improve the patients outcome.

Adolescent↗

PubMed1991

[Surgical treatment of arteriovenous malformations in eloquent zones of the brain. Apropos of eleven cases].

The site of a cerebral arteriovenous malformation, particularly in an eloquent area of the brain, is a significant factor that may influence the therapeutic approach. In these cases, surgery is often viewed as a contraindication. We report our experience of eleven consecutive cases of cerebral arterio-venous malformation in an eloquent area of the brain treated surgically. The resection was complete as confirmed by post-operative angiogram in ten patients. There were no post-operative mortality. One patient had a mild neurological deterioration and all patients have resumed their normal activities. The technical aspects which allowed these results are discussed.

Adolescent↗

PubMed1991

Spinal man after declaration of brain death.

Complex spinal automatism in a patient who was declared brain dead is described. These movements tend to appear once cerebrospinal shock has abated. We postulate that these manifestations are a reflection of the physiological potential of the isolated spinal cord. These spinal movements should be included in the revised guidelines for the determination of cerebral death.

Adult↗