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Biomedical subjects

M Vucevic

Publications and source records attributed to M Vucevic.

20 records · Page 2Linked to original sources

Spinal anaesthesia for caesarean section: 0.125% plain bupivacaine 12 ml compared with 0.5% plain bupivacaine 3 ml.

Forty women had elective Caesarean section under spinal anaesthesia with either 0.5% bupivacaine 3 ml or 0.125% bupivacaine 12 ml, injected at a rate of 1 ml/5 s. For 30 min after the spinal injection, each patient lay on her right side. Compared with the patients given 3 ml, in those given bupivacaine 12 ml there was a significantly greater spread of block (P less than 0.02 for analgesia; P less than 0.002 for touch) and significantly less variation in levels of block (P less than 0.02 for analgesia; P less than 0.04 for touch). However, within 5 min of placing the women in a supine, tilted (right hip up) position, there were no clinically or statistically significant differences in the levels of block between the two groups.

Adult↗

Comparison of atropine and glycopyrronium in patients with pre-existing cardiac disease.

The effects of atropine and glycopyrronium, when given intravenously with neostigmine during the reversal of neuromuscular blockade in patients with cardiovascular disease, were compared in a double blind trial. Atropine was associated with a significantly greater elevation of heart rate and rate-pressure product than glycopyrronium. This elevation was also more sustained with atropine. The entire atropine population also showed a significantly greater incidence of ST-segment depression on the electrocardiogram than that observed in those who had received glycopyrronium. Furthermore, patients with ischaemic heart disease and previous myocardial infarction who received atropine showed a significantly greater incidence of dysrhythmias than those given glycopyrronium. It is suggested that at the time of reversal of neuromuscular blockade in patients with cardiovascular disease, glycopyrronium is a more suitable agent than atropine.

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