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Biomedical subjects

M Vorne

Publications and source records attributed to M Vorne.

At least 55 records · Page 3Linked to original sources
PubMed1986

Venous haemodynamics in the legs after ligation of the inferior vena cava.

Doppler ultrasound and strain gauge plethysmography (SGP) were used to study venous insufficiency in 22 patients after ligation of the inferior vena cava (LIVC), 13 control patients with unilateral postthrombotic syndrome (PS) and 20 normal controls. Isotope venography was performed in eight patients. SGP showed low venous capacity in LIVC legs without deep vein thrombosis (DVT), indicating restrictive syndrome. There was no venous obstruction in any of the groups studied. In the LIVC limbs with DVT and in the PS limbs, venous reflux differed significantly from that of normal controls. The popliteal venous reflux examined by Doppler ultrasound was sporadic in LIVC limbs without DVT, occurring in 71% of LIVC limbs with DVT and in 77% of limbs with PS. Isotope venography in eight LIVC patients showed abundant collateral circulation. We conclude that DVT causes venous reflux. LIVC causes a restrictive syndrome without venous obstruction, and alone it did not cause venous reflux. Clinically it indicates that symptoms after uncomplicated LIVC are mild and that late postoperative morbidity is principally arising from DVT and not from LIVC alone.

Adolescent↗
PubMed1986

Radionuclide angiography in the assessment of lumbar sympathectomy.

Nuclear angiography was used in the assessment of the effects of lumbar sympathectomy in 16 patients. Computed nuclear angiographic study was performed before and after sympathectomy. 7 patients had a good clinical course and 9 had a poor prognosis. Visual observation and computed analysis gave almost equal information. Shortening of arrival time (ATdecrease) and increase in input rate ratio (IRratio) were the most suitable parameters in computed analysis. A good clinical course was probable if ATdecrease was greater than or equal to 5 s and IRratio greater than or equal to 1.3. Smaller values predicted poor prognosis. Preoperative Doppler ankle/arm systolic blood pressure index (API) greater than or equal to 0.50 predicted good and less than or equal to 0.50 poor clinical response. Postoperative API provided no additional information and was not able to measure the effects of sympathectomy. Radionuclide angiography was found to be a safe, noninvasive reliable method in the evaluation of peripheral circulation in the follow-up of sympathectomy.

Adult↗
PubMed1986

Clinical significance of lung uptake in liver scanning.

99mTc tin colloid accumulated in the lungs in 102 patients during liver imaging both in malignant and benign diseases. The percentage of neoplastic diseases increased when the lung uptake became greater and only patients with malignant final diagnosis had marked lung uptake. Abnormal liver image was seen only in 23%, which disagrees highly with some earlier findings on a rather small number of patients. The cause of increased lung uptake was suggested to be the activation of the reticuloendothelial system (RES) by disease. The activation of the RES was stronger in malignant than in benign diseases. Some type of regional stimulation of the RES was suggested as being due to the location of the disease and both malignant and benign diseases of the chest region stimulated the pulmonary part of the RES more than other parts of the RES.

Humans↗
PubMed1984

Detection of malignant soft tissue tumors in bone imaging.

A total of 2530 consecutive bone scans were examined to evaluate the number and the type of soft tissue neoplasms detected with bone-seeking phosphonates. Sixty-eight primary or secondary soft tissue neoplasms of 63 patients accumulated 99mTc -methylene diphosphonate and 2 accumulated 99mTc -diphosphonate, and one metastasis was seen as a nonactive 'cold' focus in the urinary bladder. The localization of tumors was: 19 in the lung, 15 in the liver, 11 in the kidney, 10 in the peritoneal cavity or ascites, 5 in the large bowel, 4 in the vascular or lymphatic system, 3 in the connective tissue or muscles, 2 in the ovary, 1 in the urinary bladder, and 1 in the brain. Our results differ in many respects from those reported in the literature. The causes of the differences are discussed.

Abdominal Neoplasms↗
PubMed1984

The spleen-to-liver ratios in hepatic diseases.

We compared light pen (LPEN) and Region of Interest (ROI) computer methods in determining spleen-to-liver (S/L) ratios both in anterior and posterior images in various liver diseases. The S/L ratio was independent of age or type of colloid used (equal particle size provided). Results with corresponding LPEN and ROI programs did not differ significantly from each other. The sensitivity and specificity were tested and the anterior view yielded somewhat better results than the posterior view but the best results were obtained when both projections were used. The sensitivity for all liver diseases was 60% and the corresponding specificity 93%. In hepatocellular diseases the sensitivity was 80-100%, but the S/L ration had only 37% sensitivity for hepatic metastases. Hepatomegaly in the anterior view was found in 67% of fatty liver cases, in 25% of cirrhosis cases, in 20% of hepatitis and in 25% of metastatic livers. Splenomegaly was noted in 39-54% of patients with hepatocellular diseases but only in 4-10% of metastatic diseases.

Adult↗
PubMed1983

A clinical comparison of 99mTc-DPD and two 99mTc-MDP agents.

Two hundred and fifty-seven patients were studied with bone-seeking radiopharmaceuticals. They were randomly divided into three groups. Two groups were injected with two different 99mTc-methylene diphosphonates from two manufacturers (MDP 1 and MDP 2) and the third group with 99mTc-dicarboxypropane diphosphonate (DPD). DPD was found to be superior with respect to blood clearance, femur to soft tissue ratio and subjectively assessed image quality. There seemed to be no marked differences between the bone-seeking agents in the visualisation of pathological foci. The image quality seemed to be better in the MDP 2 group than in the MDP 1 group but they were similar in other respects. The femur to soft tissue ratio decreased with increasing age in the DPD group but not in the MDP groups. With all agents worsening of scan quality with increasing age was noted and the image quality was better with men than with women. When short incubation times of radiopharmaceuticals were used before injection, the bone to soft tissue ratio was lower and the scan quality was poorer than with incubation times longer than 20 min.

Adult↗
PubMed1982

Tc-99m glucoheptonate in detection of lung tumors.

Sixty-three patients aged 21-80 yr were examined. Tc-99m glucoheptonate (Tc-GH) scintigraphy was performed in 32 patients: 26 with primary lung carcinoma; six with metastases in lung, mediastinum, and pleura from carcinomas elsewhere; eight with benign pulmonary diseases; and 23 without known pulmonary disease. Tc-GH accumulated in 23 of 26 primary pulmonary carcinomas as active foci. The specificity of Tc-GH scans for neoplasm detection was higher than that of chest radiographs. The visualization of malignant tumors was much better in the late Tc-GH images (5-6 hr) than in the early (1 hr). Metastases from other carcinomas were positive in four of six patients, but they were considerably better detected in the radiographs, except in one patient with metastatic hepatocellular carcinoma. Neoplasms or their metastases in the hilar and mediastinal regions were better detected in the Tc-GH scans than in the chest radiographs. Only one of eight benign lung processes was visualized (as a weak diffuse accumulation of Tc-GH in hilar scar formation), and 23 patients without pulmonary disease had no pathological foci.

Adenocarcinoma↗