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Biomedical subjects

M Volpe

Publications and source records attributed to M Volpe.

At least 199 records · Page 11Linked to original sources
PubMed1980

[Clinical evaluation of a new antianginal drug: droprenylamine].

In this study the antianginal action of droprenylamine, a cycloaliphatic derivative of prenylamine, was evaluated. Forty patients were included in three groups: in the first group a double blind study was carried out, while in the other two groups, both treated with droprenylamine for a 12 weeks period, were evaluated the effects on workload tolerance or the efficacy in reducing the number of angina pectoris episodes per week and the assumption of nitroglycerine. The double blind study shows that droprenylamine is able to reduce significantly the nitroglycerine assumption. Furthermore, during the 12 week treatment with droprenylamine we can observe a significant reduction of the ST segment depression, at comparable workloads, a significantly increased tolerance to stress test and an early and significant reduction of the angina attacks and, subsequently, of the assumption of nitroglycerine. In conclusion, this drug, which appears free of side effects, may be useful in the treatment of angina pectoris; in particular, the possible association with other antianginal drugs should be evaluated.

Adult↗
PubMed1980

Disopyramide and mexiletine: which is the agent of choice in the long term-oral treatment of lidocaine-responsive arrhythmias? Efficacy comparison in a randomized trial.

Forty patients with serious lidocaine-responsive ventricular arrhythmias were randomly assigned to treatment with either oral disopyramide (100 mg 4 times daily) or mexiletine (200 mg 4 times daily) for 3 weeks. A satisfactory arrhythmias control (greater than 75 % reduction of premature ventricular complexes per minute as compared to the control period prior to lidocaine administration) was achieved in 19 patients in the mexiletine group and in 16 in the disopyramide treated patients. Furthermore, disopyramide failed to maintain the reduction of the number of ventricular extrasystoles per minute obtained with lidocaine, while mexiletine succeeded. Finally, the number of ventricular extrasystoles per minute in the mexiletine treated group was significantly lower than in the other group. Gastrointestinal disturbances were more frequent during mexiletine administration.

Arrhythmias, Cardiac↗
PubMed1980

[The effects of the stellate ganglion electrostimulation on the coronary circulation of the dog (author's transl)].

In this study we have investigated the effects of the stellate ganglion electrostimulation on the perfusion pressure of coronary vascular bed perfused at constant flow. We always observed systemic hypertension and two kinds of response in the coronary district: vasodilatation or vasoconstriction. These responses were blocked by propranolol and phentolamine i.a. administration respectively, while both the phenomena were blocked by i.v. infection of guanethidine. These results seem to suggest that nervous sympathetic stimulation induces catecholamines release by means of either pregangliar adrenergic fibers directed to coronary vessels either postgangliar adrenergic fibres directed to the myocardium. The occurrence of vasodilatation or vasoconstriction could be explained by the prevalent stimulation of myocardial or coronary adrenoceptors.

Animals↗
PubMed1980

[Correlations between polygraphic and hemodynamic parameter changes induced by high concentrated oxygen administration in patients with mitral valvulopathy (author's transl)].

The goal of this study was to identify, utilizing apexcardiogram, other noninvasive parameters useful to evaluate the functional condition of the pulmonary vascular bed in patients with mitral stenosis and insufficiency. The patients of both sexes with mitral stenosis and insufficiency underwent left and right heart catetherization and simultaneously a polygraphic study was performed. Recordings of polygraphic as well as hemodynamic parameters were performed under control condition and after 5 min breathing of 100% Oxygen administered by facial mask. These results indicate that changes in rapid filling angle have a close relationship with changes in pulmonary capillary wedge pressure and variation of rapid filling interval are correlated with changes in pulmonary capillary wedge pressure and variation of rapid filling interval are correlated with changes in cardiac output.

Administration, Intranasal↗
PubMed1980

[Effects of metoprolol on myocardial performance in hypertensive patients during exercise (author's transl)].

In this study the effects of metoprolol administration (200 mg daily per os) to 20 hypertensive subjects (WHO stage I and II), as a 20-days course, on heart rate (HR), systolic blood pressure (BP) and myocardial performance evaluated by systolic time intervals, were studied both at rest and during exercise. This treatment was able to reduce significantly HR and BP in all the patients, both at rest and during exercise. After the 20 days treatment, the left ventricular ejection time corrected for HR (LVETc) did not show any significant change both at rest and during exercise. On the other hand, the pre-ejection period (PEP) changed at rest in all the subjects studied after metoprolol treatment, but increased significantly during exercise only in patients in the I WHO class and only at the highest work load (at 70 watts, from 63 +/- 2 to 78 +/- 7 msec, P ¿ 0.05). Furthermore, in the same group of patients the maximal work load increased significantly after metoprolol treatment (from 67.5 +/- 6 to 85 +/- 8 watts, P < 0.05).

Adult↗
PubMed1979

Effect of furosemide on plasma concentration and beta-blockade by propranolol.

Although propranolol and furosemide are used together for hypertension, the effects of furosemide on plasma levels and beta-blocking action of propranolol are not known. Ten healthy subjects received propranolol 40 mg orally; the mean plasma propranolol levels in 60, 90, 180, and 300 min were 85 +/- 16, 90 +/- 7, 82 +/- 8, and 58 +/- 8 ng/ml. Propranolol was then given together with furosemide (25 mg orally) and the propranolol blood level was measured. Mean propranolol plasma levels were 106 +/- 11 ng/ml at 60 min, 120 +/- 12 ng/ml at 90 min (p less than 0.01), 102 +/- 8 ng/ml at 180 min (p less than 0.05), and 78 +/- 8 ng/ml at 300 min (p less than 0.01). Six additional subjects were given an infusion of 1 microgram/min isoproterenol increased by 0.5 microgram/min every 2 min until the heart rate rose by 25% after oral administration of furosemide 25 mg. This procedure was repeated after propranolol (40 mg orally) and propranolol with furosemide (25 mg orally). The amount of isoproterenol which raised the heart rate by 25% was 2.6 +/- 0.3 micrograms after furosemide alone and 17.7 +/- 2 micrograms after propranolol (p less than 0.01). After propranolol with furosemide the dose of isoproterenol required to elevate heart rate by 25% was 109 +/- 15 micrograms (p less than 0.001).

Adolescent↗