[Emergency therapy in upper digestive hemorrhages in patients with liver cirrhosis].
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Adult↗
Biomedical subjects
M Vlad
Publications and source records attributed to M Vlad.
Experimental study of myocardial bridges.
Myocardial bridges were reproduced in dogs by transfer of a fragment of the left ventricular wall above the upper portion of the anterior interventricular artery. The viability of this bridge was shown by coronarography, anatomic, histologic and electron microscopic studies, illustrating the vascular patency and the integrity of blood vessels and neighbouring myocardium in the cases postoperatively heparinized. The experimental model efficiency was also proved by ECG examinations revealing ischemic distresses induced by compression of the bridge against the underlying artery.
Animals↗
Free radicals, ceruloplasmin, and copper concentration in serum and aortic tissue in experimental atherosclerosis.
It has been suggested that the increase in concentration of blood lipid peroxides may be a risk factor for atherosclerosis. Our research was conducted to study the effect of cholesterol feeding on lipid peroxides, ceruloplasmin, HDL-cholesterol, serum unesterified fatty acids, and copper concentration in serum and aortic tissue in rats. In the animals fed a cholesterol-supplemented diet, the mean values of serum lipid peroxide, ceruloplasmin, serum copper, and unesterified fatty acids were increased significantly (p < 0.01) as compared to the control group. At the same time, HDL-cholesterol concentration was significantly decreased in rats fed a diet enriched with cholesterol (p < 0.01) compared to the control group. A significant decrease of copper concentration in aorta was also observed in these animals versus controls. Correlations between ceruloplasmin and lipid peroxides as well as copper were statistically significant in these animals. At the same time, antioxidant activity in blood was two times higher as compared to controls. Results of this study provide the support for applying these determinations in atherosclerosis monitoring.
Animals↗
[Vulvar cancer. The therapeutic aspects].
Even though it has a low frequency (4 - 5%) compared to genital cancers, it has certain biological features represented by the possibility of multicentric localisation what performs on the dystrophic lesions, the presence of the inguinal nodes, the sensibility of the irradiation of the cancer and nodes and the efficacity of the treatment of the treatment of the bleomicine which request many therapeutical problems. Between 1985-1994, in Colţea Surgery Clinic there were operated 13 vulvar carcinoma, in women between 45-69 years old, in stages II (6), III (4) and IV b (3). Primary lesion was on labia major (11), labia minor (1) and posterior fourchette (1). Preoperative radiotherapy was made in 9 patients. At 3 patients, valvar lesion represents the second cancer--in all cases were syndrome neoplasia, after cervix neoplasia (2) or ano-rectal neoplasia (1) which were operated. At histopathological exam all cancers were spinocellular epithelium keratosis in 10, non-keratosis in 2 or trabecular in 1. The surgical treatment was selective and consisted in total vulvectomy (9), vulvectomy with inguinal lymphadenectomy (3) and left colostomy (1) after ano-rectal invasions and intestinal obstruction. The postoperative mortality and complications were zero. Postoperative treatment consisted in radiotherapy in association with chemotherapy 93) or only chemotherapy (8). The survival rates at 3 years (2), 5 years (30, 7 years) (3) and 10 years (2), justify the complex treatment. In conclusion, vulvectomy represents the specific treatment associated with inguinal lymphadenectomy in case of lymph nodes metastasis. Postoperative radiotherapy and postoperative chemotherapy seem to increase the survival rate.
Animals↗
[Laparoscopic cholecystectomy in acute cholecystitis].
AIM: Results evaluation of laparoscopic cholecystectomy in acute cholecystitis. MATERIAL AND METHOD: Between 1994-1997 we performed 65 laparoscopic cholecystectomies for histopathologically proved acute lithiasic cholecystitis. We studied clinic and echographic diagnosis, operative moment, conversion rate, operative time, postoperative morbidity and hospitalization. The cholecystectomy was performed within 72 hours in 18 patients (trial I), 4 to 7 days in 25 patients (trial II) and over 7 days in 22 patients (trial III). RESULTS: Diagnosis of acute lithiasic cholecystitis was always possible by clinical examination and ultrasonography. We performed 8 conversions in patients of trial II (2) and III (6). The mean operative time was 68 min. Postoperative morbidity consisted in 4 bile leakages in the liver bed, 1 subhepatic abscess, 5 right pleural effusions. The mean hospitalization was 4.4 days. CONCLUSIONS: Urgent laparoscopic cholecystectomy is a beneficial act for acute lithiasic cholecystitis. The operative moment is the most important factor of influence on conversion rate, operative time and postoperative morbidity.
Acute Disease↗