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Biomedical subjects

M Vincent

Publications and source records attributed to M Vincent.

At least 343 records · Page 19Linked to original sources
PubMed1982

[Value of the study of trigeminal nerve evoked potentials in chronic trichloroethylene poisoning. Preliminary results].

Results of a study concerning the trigeminal nerve impairment as the one caused by trichlorethylene chronic intoxication by somatosensory evoked potential reveal three kinds of anomalies: increase of the stimulation voltage, excessive latency delay with morphological anomalies and excessive graph amplitude. These anomalies confirm clinical disturbance (hypoesthesia in the trigeminal area) and open a debate about the real mechanism of the trichlorethylene neurotoxicity.

Adult↗
PubMed1981

Radioimmunoassay for urinary prostaglandins E and F alpha: normal values in different age groups.

A new radioimmunoassay for urinary prostaglandins E and F alpha is described which allows the extraction and chromatographic separation of urinary prostaglandins with an overall recovery of 80.5% and 89.3% for prostaglandins E2 and F2 alpha respectively. The antibodies raised in the rabbit could not distinguish prostaglandins of series 1 and 2 but were found highly specific towards their metabolites and other primary prostaglandins. The sensitivity of the assay developed was at 2.2 pg for prostaglandin E and 2pg for prostaglandin F alpha. This assay was applied to normal adults of both sexes; it was shown that the daily urinary excretion of prostaglandins F alpha and E was greater in men than in women. In children aged from 1 to 114 months, the urinary excretion of prostaglandins increased with age. This increase was more marked during the first two years of life and was significantly related to age.

Adult↗
PubMed1981

[Electrophoresis of the membrane proteins of erythrocytes of spontaneously hypertensive rats].

The red blood cell membrane proteins of normal and spontaneous hypertensive Rats were studied by gradient polyacrylamide gel electrophoresis. The electrophoretic patterns of membrane proteins of hypertensive rats show three new bands of 58,000, 24,000 and 22,000 dalton. The existence of these new bands is not correlated with the age and the blood pressure values of the animals.

Animals↗
PubMed1981

Plasma vasopressin, renin activity, and aldosterone: effect of exercise and training.

The influence of endurance-training on hematocrit, plasma vasopressin, renin activity, and aldosterone changes at rest and at the end of an exercise performed until exhaustion at a given and constant relative work-load (87% of maximal oxygen uptake) has been studied in four untrained subjects submitted to a 5-month training. At the end of this period, maximal oxygen uptake increased of 15.2% (p less than 0.01). Hematocrit at rest slightly rose after training, and if exercise constantly induced increases in hematocrit before (p less than 0.001) and after training (p less than 0.005), the per cent increase after training was lower than before (p less than 0.05). Comparison between the importance of weight loss and hematocrit variation showed that when untrained subjects become trained the variation of hematocrit after exercise becomes smaller while weight loss is more important (p less than 0.01). Plasma renin activity (PRA), aldosterone (Aldo) and vasopressin (AVP) levels, compared to control values, displayed a significant increase after exercise before as well as after training. Control values remained unchanged after training for aldosterone and AVP, but were significantly lower (p less than 0.05) for PRA. This latter observation could be explained by the change in blood volume induced by exercise.

Adult↗
PubMed1981

Computed tomographic angiography.

Computed tomographic angiography performed by the intravenous administration of contrast medium was evaluated in 86 vascular patients. This experience demonstrates a new approach to the evaluation of patients with symptomatic aortic aneurysms, in whom computed tomographic angiography will aid in evaluating the need for emergency surgery. Nonoperative patients are serially evaluated by computed tomographic angiography to detect significant changes in the geometric configuration of their aneurysms. Computed tomographic angiography was beneficial in the evaluation of the patency of vascular reconstructive procedures such as femoropopliteal bypass, aortoiliac bypass and application of a vena caval device. More clinical experience and possibly a rapid sequence technique are needed to evaluate patients with portasystemic shunts.

Abdomen↗
PubMed1981

Urinary excretion of prostaglandins and electrolytes in developing children.

A longitudinal study of the urinary excretion of prostaglandins (PG's) E and Falpha was performed in 55 healthy children aged from 1 to 114 months. In addition, the urinary PG's and electrolytes were studied in 6 children with Bartter's syndrome before and after an oral treatment with indomethacin. In normal children, both urinary PGE and PGF alpha increased with age, more markedly before 24 months of age. During this period, a positive and significant correlation was found with the urinary osmolality (r = 0.61, N = 16, P less than 0.05 for PGE; r = 0.82, N = 16, P less than 0.001 for PGF alpha). At every age, the urinary PG's were related to the potassium excretion (r = 0.68, N = 55, P less than 0.001 for PGE; r = 0.65, N = 55, P less than 0.002 for PGFalpha) but not to the natriuresis. In children with Bartter's syndrome, the increased urinary excretion of PGE, PGFalpha and potassium when the natriuresis was either decreased or increased after treatment. These results suggest that the renal PG's might play a role in the control of potassium excretion by the kidney. In addition, the determination of normal values in different age groups appears necessary for an accurate interpretation of the urinary PG's.

Bartter Syndrome↗
PubMed1981

Biosynthesis and characterization of heat shock proteins in Chironomus tentans salivary glands.

The protein synthesis response of Chironomus tentans salivary glands to a heat shock was analyzed by means of [3H]leucine pulse labeling, sodium dodecyl sulfate - polyacrylamide slab gels, and fluorography. Seven new cytoplasmic polypeptides with relative masses (Mr) of 90 000, 76 000, 73 000, 68 000, 28 000, 25 000, and 22 000 are synthesized in response to a 39 degrees C heat shock (HS) while the synthesis of most of the normal proteins is reduced. The major HS-induced protein is the 68 000 species. The length of the heat treatment does not modify markedly the pattern of induced proteins but the temperature has an effect: while the responses at 37 and 39 degrees C are similar, two HS-induced polypeptides (Mr 90 000 and 76 000) are not seen after a treatment at 41 degrees C. Kinetic studies of the response show an asynchrony in the appearance of the various HS proteins indicating that their individual rates of synthesis differ or that their induction is not fully coordinated. No significant differences were found between the protein patterns of a mitochondria-rich cytoplasmic zone obtained by microdissection and the whole cytoplasm, but two heat-induced proteins are present in the microdissected nuclei: a 68 000 polypeptide, comigrating with the major cytoplasmic one, and a 34 000 protein, almost exclusively seen in the nucleus.

Animals↗
PubMed1981

Relationships between blood pressure and plasma renin, aldosterone and dopamine-beta--hydroxylase in the elderly. Studies in patients over 70 years of age.

Plasma renin activity (PRA), aldosterone (PA) and dopamine-beta-hydroxylase activity (DBH) were measured in 49 subjects over 70 years of age, selected for normal or high blood pressure level. By comparison with younger controls, elderly subjects exhibited lower supine or upright PRA, but similar PA and DBH. No relationship could be found between individual blood pressure, and PRA, PA or DBH. The data favor the view that the renin-angiotensin-aldosterone system does not play an important causative role in elderly hypertension. They also point to the necessity of age-matched controls when this system is being studied in elderly patients.

Aged↗
PubMed1981

Cyanide and its relationship to nervous suffering. Physiopathological aspects of intoxication.

On the basis of personal results in man and laboratory animal, we examined some aspects of acute and chronic cyanide intoxication: physiopathological aspects, hydroxocobalamin's therapeutic action in treating acute intoxications and neurotoxic sufferings due to cyanide, and hydroxocobalamin's biological action in decreasing the level of free cyanide appearing in blood and urine, a few days after sciatic nerve clamping in rabbits.

Animals↗
PubMed1981

A longitudinal study of plasma renin activity during normal and preeclamptic pregnancy.

In 68 pregnant women, blood samples were obtained at 12, 20, 25, 29, 32 and 36 weeks. Plasma renin activity (PRA) was measured in 10 of them, who developed "pregnancy induced hypertension" ("PIH") and in 10 normal pregnant women, matched with the hypertensive patients for age, parity and body weight. Towards the end of pregnancy, PRA showed a tendency to increase in the "PIH" group, and to decrease in the control group. However, these variations were not statistically significant. There was no significant difference between the two groups, except for the last measurement, obtained at the 36th week of gestation. At this time, PRA was more elevated in the PIH group. We conclude that PRA measurements early in pregnancy are of no value in predicting if women are going to develop PIH.

Female↗
PubMed1981

[Plasma renin activity (PRA) and aldosterone (PA) during submaximal exercise. Effect of training (author's transl)].

The effect of training on PRA, PA, hematocrit and weight loss was studied at rest and following an exercise performed until exhaustion. Two groups of subjects were used, the first, a group of 4 young well trained men (88.6% +/- 7.7 V02 max) and the second a group of 4 young untrained men (77.5% +/- 7 V02 max). PRA and PA displayed highly significant increases after exercise in both groups, but PRA resting values were lower in the well trained subjects (p less than 0.05). PRA values were also lower in the latter group after exercise, but the difference in this case was not significant. Further, the variation of hematocrit was less (p less than 0.05) and the weight loss greater in the well trained subjects. In an additional experiment, the same parameters were studied in four subjects submitted to a five month training programme (87% V02 max). Though resting values for PA remained unchanged after training, PRA resting values and PRA post exercise values were significantly lower. A comparison between the magnitude of weight loss and hematocrit variation showed that when untrained subjects became trained, the variation of hematocrit was smaller (p less than 0.05) while weight loss was larger (p less than 0.01). These observations could be explained in terms of the change in blood volume, and/or a decrease in sympathetic nervous activity induced by training.

Adult↗
PubMed1981

[Induction of sister chromatide exchange by trichloroethylene and its metabolites (author's transl)].

The mutagenecity of trichloroethylene and its metabolites (trichloroethanol and chloral hydrate) have been tested by using the method of sister chromatide exchanges (SCE). We have found the increasing SCE in workers chronically exposed to trichloroethylene. The increasing of SCE was also observed when the human lymphocytes were exposed to trichloroethanol and chloral hydrate in vitro in certain concentrations. The all results of tests groups are compared with those of the control groups and the difference is statistically significant.

Chloral Hydrate↗