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M Vilardell Tarres

Publications and source records attributed to M Vilardell Tarres.

11 recordsLinked to original sources
PubMed1997

[Hemorrhagic complications and thrombotic phenomena in oral anticoagulation of elderly patients].

OBJECTIVE: To retrospectively analyze the hemorrhagic complications and thrombotic events associated with aging and the degree of anticoagulation in a series of ambulatory patients treated with acenocumarol and controlled in a specialized anticoagulant therapy unit. PATIENTS AND METHODS: A total of 1,613 ambulatory patients were studied. Patients were divided into two groups (group 1, 645 patients > 65 years old, mean age 71.7 +/- 4.5 years; INR, 2.1-2.8; group 2, 968 patients < or = 65 years, mean age 53.7 +/- 10 years; INR, 2.8-4.2) for a time period of twelve months. The prevalence of hemorrhagic complications and severity according to a validated international index (Bleeding Severity Index), as well as the thrombotic events occurred despite anticoagulation therapy. RESULTS: Fifty-two hemorrhagic events (8/100 patients-year) were recorded in the older group (group 1). Twenty-six cases were considered banal episodes, 24 minor hemorrhages and two major hemorrhages. Ten patients (1.5/100 patients-year) had thrombotic complications. In the younger group (group 2) 150 bleeding episodes were recorded (15 patients-year), of which 11 were banal, 39 minor hemorrhages and no major hemorrhages. Only eight patients 0.8/100 patients-year) had thrombosis. The presence of local factors predisposing to bleeding was more common in group 1 (p < 0.001). Older patients had in general more complications than younger patients (p < 0.001), but no significant differences were observed between the occurrence of hemorrhages or thrombosis independently analyzed between both groups. The rate in the therapeutic range was greater among the youngest individuals (p < 0.05). CONCLUSIONS: Our results support the idea that patients with advanced age can benefit from a less aggressive anticoagulation. A statistical trend was observed, although not significant, towards the presence of major hemorrhages and thrombosis in this group of patients. The presence of local or predisposing factors to hemorrhage (underlying disease and NSAIDs use) is more relevant in patients with advanced age.

Acenocoumarol↗
PubMed1995

[Anti-beta 2 glycoprotein I antibodies. Relationship with antiphospholipid antibodies and thrombosis].

BACKGROUND: Anti-beta 2-glycoprotein I antibodies (a beta 2GPI) were studied in patients with diseases or clinical symptoms related to antiphospholipid antibodies (aPl) with the aim of establishing a relationship between both antibodies and these clinical manifestations. METHODS: The a beta 2GPI antibodies were determined by enzymeimmunoassay in a group of 94 altruist blood donors and 135 patients (98 with systemic lupus erythematosus, 21 cases of primary antiphospholipid syndrome, 10 cases with idiopathic Sneddon syndrome and 6 with Q fever). The lupus anticoagulating-type aPl antibodies were determined in the same subjects by kaolin coagulation time and the Russell's viper venom time while anticardiolipin-type IgG, IgM and IgA isotypes were determined by enzymeimmunoassay. The a beta 2GPI antibodies were related with the aPl antibodies, fetal losses and history of thrombosis by a contingency table with Yates correction in the first two parameters and means comparison by the Students' t test for the history of thrombosis. RESULTS: The aPl and a beta 2GPI antibodies in the control group were negative. In the group of patients the latter antibodies were positive in 33.6% (33 cases) of the patients with lupus, 57% (12 cases) of the patients with primary antiphospholipid syndrome, in one of the patients with the Sneddon syndrome and in none of the patients with Q fever. The aPl antibodies were positive in 26.5% of the patients with lupus and in 100% of the cases with primary antiphospholipid syndrome or Q fever and negative in all the cases with idiopathic Sneddon syndrome. A significant relationship was found between the a beta 2GPI antibodies and thrombotic manifestations (p = 0.01) or obstetric complications (p < 0.04). A dependent relationship was observed in both autoantibodies (aPl and a beta 2GPI) (p < 0.01). CONCLUSIONS: There is a significant relationship between the antiphospholipid antibodies and the anti-beta 2-glycoprotein I antibodies in addition to a relationship with thrombotic symptoms or obstetric complications.

Adolescent↗
PubMed1989

[Study and significance of cryoimmunoglobulins in chronic liver diseases].

The presence, composition and significance of cryoglobulins was studied in a group of 80 patients suffering from different chronic liver diseases. 43 patients (53.75%) had detectable levels of cryoglobulins and there was a significant correlation (p less than 0.02) between the presence of these and the group of chronic active hepatitis. The immunochemical analysis of the cryoglobulins showed a clear predominance of type III (mixed polyclonal). There was a statistically significant correlation (p less than 0.001) between the appearance of cryoglobulins in chronic liver disease (in general) and extrahepatic clinical manifestations. When the subgroups were analyzed, this correlation was significant in the group of patients with chronic active hepatitis (p less than 0.002) and in those with liver disease of unknown origin (p less than 0.001). The type of cryoglobulins most frequently found in the group of patients with extrahepatic manifestations was also type III (mixed polyclonal).

Adolescent↗
PubMed1980

[Cryofibrinogen].

Explore the source record for details and available documents.

Cryoglobulins↗
PubMedDate not supplied

[Echocardiographic manifestations in patients with hypereosinophilia].

In order to assess the degree and type of cardiac involvement in patients with sustained hypereosinophilia, we studied by two-dimensional, M-mode echocardiography and Doppler (4 cases) 20 patients distributed into 2 groups. Group I: 10 patients with the idiopathic hypereosinophilic syndrome. Group II: 10 patients with secondary hypereosinophilia. In group I, 6 patients (60%) had echocardiographic abnormalities consistent with the endomyocardial disease: four apical obliteration of right ventricle, three apical obliteration of left ventricle, three endocardial thickening of the left ventricle, three endocardial thickening of the left ventricle posterior wall, one endocardial thickening of the right ventricle free wall, three subvalvular mitral thickening, three subvalvular tricuspid thickening, two pericardial effusion and two protodiastolic septal notch. These corresponded to 2 cases of endomyocardial fibrosis and restriction, as shown by pathological and hemodynamic study. In only 1 patient from group II echocardiographic abnormalities consistent with right apical occupation and tricuspid subvalvular thickening, with mild regurgitation detected by Doppler, were found. It was concluded that echocardiographic abnormalities are common in patients with idiopathic hypereosinophilic syndrome, even in the absence of clinical features. The development of echocardiographic abnormalities in patients with sustained secondary hypereosinophilia is exceptional and is probably related to duration of eosinophilia. Therefore, we think that echo-Doppler is a fundamental investigation for the diagnosis and follow-up of these patients.

Adult↗